A study of the cis–trans isomerization preference of N-alkylated peptides containing phosphorus in the side chain and backbone

2019 ◽  
Vol 43 (32) ◽  
pp. 12804-12813 ◽  
Author(s):  
Alexander F. de la Torre ◽  
Akbar Ali ◽  
Odette Concepcion ◽  
Ana L. Montero-Alejo ◽  
Francisco M. Muñiz ◽  
...  
Keyword(s):  
Current Work ◽  
Side Chain ◽  
Trans Isomerization

The current work provides a study on the cis–trans isomerization behaviour of N-alkylated peptides decorated with phosphonate ester groups.

scholarly journals DOCLASP - Docking ligands to target proteins using spatial and electrostatic congruence extracted from a known holoenzyme and applying simple geometrical transformations

F1000Research ◽  
2014 ◽  
Vol 3 ◽  
pp. 262 ◽  
Author(s):  
Sandeep Chakraborty
Keyword(s):  
Bacillus Cereus ◽  
Phospholipase C ◽  
Protein Docking ◽  
Target Protein ◽  
Current Work ◽  
Side Chain ◽  
Contact Points ◽  
Enzymatic Function ◽  
Target Enzyme

The ability to accurately and effectively predict the interaction between proteins and small drug-like compounds has long intrigued researchers for pedagogic, humanitarian and economic reasons. Protein docking methods (AutoDock, GOLD, DOCK, FlexX and Glide to name a few) rank a large number of possible conformations of protein-ligand complexes using fast algorithms. Previously, it has been shown that structural congruence leading to the same enzymatic function necessitates the congruence of electrostatic properties (CLASP). The current work presents a methodology for docking a ligand into a target protein, provided that there is at least one known holoenzyme with ligand bound - DOCLASP (Docking using CLASP). The contact points of the ligand in the holoenzyme defines a motif, which is used to query the target enzyme using CLASP. If there are no significant matches, the ligand cannot be docked in the protein. Otherwise, the holoenzyme and the target protein are superimposed based on congruent atoms. The same linear and rotational transformations are also applied to the ligand, thus creating a unified coordinate framework having the holoenzyme, the ligand and the target enzyme. This provides the docked ligand in the target enzyme. Previously, CLASP was used to predict and validate (in vivo) the inhibition of phosphoinositide-specific phospholipase C (PI-PLC) from Bacillus cereus by two dipeptidyl peptidase-IV (DPP4) inhibitors - vildagliptin and K-579. In the current work, vildagliptin was docked to the PI-PLC structure complexed with myo-inositol using DOCLASP. The docked ligand is free from steric clashes and interacts with the same side chain residues that bind myo-inositol, providing corroboration of the validity of the proposed methodology.

Photocontrol of polypeptide membrane functions by cis-trans isomerization in side-chain azobenzene groups

1986 ◽  
Vol 19 (1) ◽  
pp. 51-55 ◽  
Author(s):  
Takatoshi Kinoshita ◽  
Morimasa Sato ◽  
Akira Takizawa ◽  
Yoshiharu Tsujita
Keyword(s):  
Side Chain ◽  
Trans Isomerization ◽  
Azobenzene Groups

scholarly journals DOCLASP - Docking ligands to target proteins using spatial and electrostatic congruence extracted from a known holoenzyme and applying simple geometrical transformations

F1000Research ◽  
2014 ◽  
Vol 3 ◽  
pp. 262 ◽  
Author(s):  
Sandeep Chakraborty
Keyword(s):  
Bacillus Cereus ◽  
Phospholipase C ◽  
Protein Docking ◽  
Target Protein ◽  
Current Work ◽  
Side Chain ◽  
Contact Points ◽  
Enzymatic Function ◽  
Target Enzyme

The ability to accurately and effectively predict the interaction between proteins and small drug-like compounds has long intrigued researchers for pedagogic, humanitarian and economic reasons. Protein docking methods (AutoDock, GOLD, DOCK, FlexX and Glide to name a few) rank a large number of possible conformations of protein-ligand complexes using fast algorithms. Previously, it has been shown that structural congruence leading to the same enzymatic function necessitates the congruence of electrostatic properties (CLASP). The current work presents a methodology for docking a ligand into a target protein, provided that there is at least one known holoenzyme with ligand bound - DOCLASP (Docking using CLASP). The contact points of the ligand in the holoenzyme defines a motif, which is used to query the target enzyme using CLASP. If there are no significant matches, the ligand cannot be docked in the protein. Otherwise, the holoenzyme and the target protein are superimposed based on congruent atoms. The same linear and rotational transformations are also applied to the ligand, thus creating a unified coordinate framework having the holoenzyme, the ligand and the target enzyme. This provides the docked ligand in the target enzyme. Previously, CLASP was used to predict and validate (in vivo) the inhibition of phosphoinositide-specific phospholipase C (PI-PLC) from Bacillus cereus by two dipeptidyl peptidase-IV (DPP4) inhibitors - vildagliptin and K-579. In the current work, vildagliptin was docked to the PI-PLC structure complexed with myo-inositol using DOCLASP. The docked ligand is free from steric clashes and interacts with the same side chain residues that bind myo-inositol, providing corroboration of the validity of the proposed methodology.

Modification of Aminosilicone Oil with Long Side-Chain and its Application on Fabric Finishing

2012 ◽  
Vol 468-471 ◽  
pp. 2090-2093 ◽  
Author(s):  
Lu Cai ◽  
Zhan Xiong Li ◽  
Li Ping Du
Keyword(s):  
Chemical Modification ◽  
Silicone Oil ◽  
Retention Rate ◽  
Condensation Reaction ◽  
Current Work ◽  
Side Chain ◽  
Reactive Carbon ◽  
The Stability ◽  
Fabric Finishing

In the current work, aminopropyl silicone oil was prepared by condensation reaction followed by chemical modification with high reactive carbon-17 mono-isocyanate. The stability of the emulsion of modified silicone oil was found to be excellent as compared with the untreated silicone oil. The modified silicone oil afforded better yellowing resistance, softness and laundry endurance, with stiffness change only 6.94% and handle retention rate 88.89% after ten launderings.

scholarly journals Photocontrol of Polypeptide Membrane Structure and Functions by cis-trans Isomerization in Side-Chain Azobenzenesulfonate Groups

1989 ◽  
Vol 21 (7) ◽  
pp. 533-541 ◽  
Author(s):  
Morimasa Sato ◽  
Takatoshi Kinoshita ◽  
Akira Takizawa ◽  
Yoshiharu Tsujita ◽  
Toshihiko Osada
Keyword(s):  
Membrane Structure ◽  
Side Chain ◽  
Trans Isomerization ◽  
Structure And Functions

Thermal Cis-Trans Isomerization Rates of Azobenzenes Bound in the Side Chain of Some Copolymers and Blends

1994 ◽  
Vol 27 (17) ◽  
pp. 4781-4786 ◽  
Author(s):  
C. Barrett ◽  
A. Natansohn ◽  
P. Rochon
Keyword(s):  
Side Chain ◽  
Trans Isomerization

Impairment Tutorial: Rating Facial Disfigurement After an Injury

1998 ◽  
Vol 3 (4) ◽  
pp. 6-6
Author(s):  
Marc T. Taylor
Keyword(s):  
Current Work ◽  
Workers Compensation ◽  
Loss Of Function ◽  
Facial Disfigurement ◽  
Work Related ◽  
Work Related Injury ◽  
Compensation Claim ◽  
Impairment Ratings

Abstract This article discusses two important cases that involve the AMA Guides to the Evaluation of Permanent Impairment (AMA Guides). First, in Vargas v Industrial Com’n of Arizona, a claimant had a pre-existing non–work-related injury to his right knee as well as a work-related injury, and the issue was apportionment of the pre-existing injury. The court held that, under Arizona's statute, the impairment from the pre-existing injury should be subtracted from the current work-related impairment. In the second case, Colorado courts addressed the issue of apportionment in a workers’ compensation claim in which the pre-existing injury was asymptomatic at the time of the work-related injury (Askey v Industrial Claim Appeals Office). In this case, the court held that the worker's benefits should not be reduced to account for an asymptomatic pre-existing condition that could not be rated accurately using the AMA Guides. The AMA Guides bases impairment ratings on anatomic or physiologic loss of function, and if an examinee presents with two or more sequential injuries and calculable impairments, the AMA Guides can be used to apportion between pre-existing and subsequent impairments. Courts often use the AMA Guides to decide statutorily determined benefits and are subject to interpretation by courts and administrative bodies whose interpretations may vary from state to state.

Structuring Situational Information

2015 ◽  
Vol 20 (3) ◽  
pp. 176-189 ◽  
Author(s):  
John F. Rauthmann
Keyword(s):  
Statistical Analyses ◽  
Current Work ◽  
Common Language ◽  
Road Map ◽  
Taxonomic Approach ◽  
Situational Information

Abstract. There is as yet no consensually agreed-upon situational taxonomy. The current work addresses this issue and reviews extant taxonomic approaches by highlighting a “road map” of six research stations that lead to the observed diversity in taxonomies: (1) theoretical and conceptual guidelines, (2) the “type” of situational information studied, (3) the general taxonomic approach taken, (4) the generation of situation pools, (5) the assessment and rating of situational information, and (6) the statistical analyses of situation data. Current situational taxonomies are difficult to integrate because they follow different paths along these six stations. Some suggestions are given on how to spur integrated taxonomies toward a unified psychology of situations that speaks a common language.

Measuring the Situational Eight DIAMONDS Characteristics of Situations

2016 ◽  
Vol 32 (2) ◽  
pp. 155-164 ◽  
Author(s):  
John F. Rauthmann ◽  
Ryne A. Sherman
Keyword(s):  
Psychological Characteristics ◽  
Current Work

Abstract. It has been suggested that people perceive psychological characteristics of situations on eight major dimensions ( Rauthmann et al., 2014 ): The “Situational Eight” DIAMONDS (Duty, Intellect, Adversity, Mating, pOsitivity, Negativity, Deception, Sociality). These dimensions have been captured with the 32-item RSQ-8. The current work optimizes the RSQ-8 to derive more economical yet informative and precise scales, captured in the newly developed S8*. Nomological associations of the original RSQ-8 and the S8* with situation cues (extracted from written situation descriptions) were compared. Application areas of the S8* are outlined.

Electroluminescent properties of side-chain naphthalimide-derivated polymers

1998 ◽  
Vol 95 (6) ◽  
pp. 1351-1354 ◽  
Author(s):  
C.-M. Bouché ◽  
P. Le Barny ◽  
H. Facoetti ◽  
F. Soyer ◽  
P. Robin
Keyword(s):  
Side Chain
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