Doxorubicin release by magnetic inductive heating and in vivo hyperthermia-chemotherapy combined cancer treatment of multifunctional magnetic nanoparticles

2019 ◽  
Vol 43 (14) ◽  
pp. 5404-5413 ◽  
Author(s):  
Phuong Thu Ha ◽  
Thi Thu Huong Le ◽  
Thuc Quang Bui ◽  
Hong Nam Pham ◽  
Anh Son Ho ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Drug Release ◽  
Cancer Treatment ◽  
Treatment Efficacy ◽  
Inductive Heating ◽  
Control Drug ◽  
Doxorubicin Release ◽  
Control Drug Release

Multifunctional nanosystems help to control drug release and highly improve the cancer treatment efficacy in in vivo models.

scholarly journals Magnetically Responsive Smart Nanoparticles for Cancer Treatment with a Combination of Magnetic Hyperthermia and Remote-Control Drug Release

Theranostics ◽  
2014 ◽  
Vol 4 (8) ◽  
pp. 834-844 ◽  
Author(s):  
Koichiro Hayashi ◽  
Michihiro Nakamura ◽  
Hirokazu Miki ◽  
Shuji Ozaki ◽  
Masahiro Abe ◽  
...  
Keyword(s):  
Remote Control ◽  
Drug Release ◽  
Cancer Treatment ◽  
Magnetic Hyperthermia ◽  
Control Drug ◽  
Control Drug Release

808 nm near-infrared light controlled dual-drug release and cancer therapy in vivo by upconversion mesoporous silica nanostructures

2017 ◽  
Vol 5 (11) ◽  
pp. 2086-2095 ◽  
Author(s):  
Yunlu Dai ◽  
Huiting Bi ◽  
Xiaoran Deng ◽  
Chunxia Li ◽  
Fei He ◽  
...  
Keyword(s):  
Drug Release ◽  
Near Infrared ◽  
Infrared Light ◽  
Anticancer Efficacy ◽  
Control Drug ◽  
Silica Nanostructures ◽  
Controlled Release System ◽  
Control Drug Release ◽  
Dual Drug

A dual-drug co-delivery and 808 nm NIR photo-controlled release system can control drug release behaviour and enhance anticancer efficacy.

scholarly journals On-Demand Drug Release System for In Vivo Cancer Treatment through Self-Assembled Magnetic Nanoparticles

2013 ◽  
Vol 52 (16) ◽  
pp. 4384-4388 ◽  
Author(s):  
Jae-Hyun Lee ◽  
Kuan-Ju Chen ◽  
Seung-Hyun Noh ◽  
Mitch André Garcia ◽  
Hao Wang ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Drug Release ◽  
Cancer Treatment ◽  
Release System ◽  
On Demand ◽  
Drug Release System ◽  
Self Assembled

On-Demand Drug Release System for In Vivo Cancer Treatment through Self-Assembled Magnetic Nanoparticles

2013 ◽  
Vol 125 (16) ◽  
pp. 4480-4484 ◽  
Author(s):  
Jae-Hyun Lee ◽  
Kuan-Ju Chen ◽  
Seung-Hyun Noh ◽  
Mitch André Garcia ◽  
Hao Wang ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Drug Release ◽  
Cancer Treatment ◽  
Release System ◽  
On Demand ◽  
Drug Release System ◽  
Self Assembled

Microencapsulation and Nanoencapsulation: A Review

2017 ◽  
Vol 9 (3) ◽  
Author(s):  
V. Suganya ◽  
V. Anuradha
Keyword(s):  
Drug Release ◽  
New Technology ◽  
Inert Material ◽  
Food Industries ◽  
Control Drug ◽  
Advantages And Disadvantages ◽  
Nano Scale ◽  
Pharmaceutical Industries ◽  
The Difference ◽  
Control Drug Release

Encapsulation is a process of enclosing the substances within an inert material which protects from environment as well as control drug release. Recently, two type of encapsulation has been performed in several research. Nanoencapsulation is the coating of various substances within another material at sizes on the nano scale. Microencapsulation is similar to nanoencapsulation aside from it involving larger particles and having been done for a greater period of time than nanoencapsulation. Encapsulation is a new technology that has wide applications in pharmaceutical industries, agrochemical, food industries and cosmetics. In this review, the difference between micro and nano encapsulation has been explained. This article gives an overview of different methods and reason for encapsulation. The advantages and disadvantages of micro and nano encapsulation technology were also clearly mentioned in this paper.

Co-delivery of Doxorubicin and D-α-Tocopherol Polyethylene Glycol 1000 Succinate by Magnetic Nanoparticles

2018 ◽  
Vol 18 (8) ◽  
pp. 1138-1147 ◽  
Author(s):  
Esra Metin ◽  
Pelin Mutlu ◽  
Ufuk Gündüz
Keyword(s):  
Breast Cancer ◽  
Polyethylene Glycol ◽  
Magnetic Nanoparticles ◽  
Cancer Treatment ◽  
Cancer Cells ◽  
Drug Loading ◽  
Gravimetric Analysis ◽  
Polyethylene Glycol 1000 ◽  
Mcf 7

Background: Although conventional chemotherapy is the most common method for cancer treatment, it has several side effects such as neuropathy, alopecia and cardiotoxicity. Since the drugs are given to body systemically, normal cells are also affected, just like cancer cells. However, in recent years, targeted drug delivery has been developed to overcome these drawbacks. Objective: The aim of this study was targeted co-delivery of doxorubicin (Dox) which is an anticancer agent and D-α-Tocopherol polyethylene glycol 1000 succinate (vitamin E TPGS or simply TPGS) to breast cancer cells. For this purpose, Magnetic Nanoparticles (MNPs) were synthesized and coated with Oleic Acid (OA). Coated nanoparticles were encapsulated in Poly Lactic-co-Glycolic Acid (PLGA) and TPGS polymers and loaded with Dox. The Nanoparticles (NPs) were characterized by Fourier Transform Infrared (FTIR) spectroscopy, zetapotential analysis, Dynamic Light Scattering (DLS) analysis, Thermal Gravimetric Analysis (TGA) and Scanning Electron Microscope (SEM) analysis. Results: The results showed that NPs were spherical, superparamagnetic and in the desired range for use in drug targeting. The targetability of NPs was confirmed. Moreover, TPGS and Dox loading was shown by TGA and FTIR analyses. NPs were internalized by cells and the cytotoxic effect of drug loaded NPs on sensitive (MCF-7) and drug-resistant (MCF-7/Dox) cells were examined. It was seen that the presence of TPGS increased cytotoxicity significantly. TPGS also enhanced drug loading efficiency, release rate, cellular internalization. In MCF- 7/Dox cells, the drug resistance seems to be decreased when Dox is loaded onto TPGS containing NPs. Conclusion: This magnetic PLGA nanoparticle system is important for new generation targeted chemotherapy and could be used for breast cancer treatment after in vivo tests.

scholarly journals The ABCG2 multidrug transporter is a pump gated by a valve and an extracellular lid

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Narakorn Khunweeraphong ◽  
Daniel Szöllősi ◽  
Thomas Stockner ◽  
Karl Kuchler
Keyword(s):  
Drug Release ◽  
Molecular Mechanism ◽  
Salt Bridge ◽  
Multidrug Transporter ◽  
Peristaltic Pump ◽  
Disulfide Bridges ◽  
Control Drug ◽  
Atp Binding Cassette Transporter ◽  
Extracellular Loops ◽  
Control Drug Release

AbstractThe human ATP-binding cassette transporter ABCG2 is a key to anticancer resistance and physiological detoxification. However, the molecular mechanism of substrate transport remains enigmatic. A hydrophobic di-leucine motif in the ABCG2 core separates a large intracellular cavity from a smaller upper cavity. We show that the di-leucine motif acts as a valve that controls drug extrusion. Moreover, the extracellular structure engages the re-entry helix and all extracellular loops to form a roof architecture on top of the upper cavity. Disulfide bridges and a salt bridge limit roof flexibility, but provide a lid-like function to control drug release. We propose that drug translocation from the central to the upper cavities through the valve is driven by a squeezing motion, suggesting that ABCG2 operates similar to a peristaltic pump. Finally, the roof contains essential residues, offering therapeutic options to block ABCG2 by either targeting the valve or essential residues in the roof.

scholarly journals Organic Functionalization of Mesoporous Silica Spheres as a Nanovehicle for DOX pH-Triggered Delivery

NANO ◽  
2019 ◽  
Vol 14 (08) ◽  
pp. 1950094 ◽  
Author(s):  
Shuai Wang ◽  
Fang Xiang Song ◽  
Li Zhang ◽  
Xue Zhang ◽  
Yan Li
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Mesoporous Silica ◽  
A549 Cells ◽  
Carboxyl Groups ◽  
Organic Functionalization ◽  
Control Drug ◽  
Potential Applications ◽  
Control Drug Release ◽  
Mesoporous Silica Spheres

Mesoporous silica (MS) spheres of different sizes with pH-responsive characteristics were synthesized based on Stöber’s theory. Organic functionalization with aminopropyl and carboxyl groups resulted in different materials, namely, MS@NH2@COOH. MS@NH2@COOH were observed to have a large number of carboxyl groups and multiamine chains, and were grafted into pore channels and pore outlets through systematic characterization analyses. All modified samples demonstrated the controlling of the delivery rate of DOX from the siliceous matrix. We also compared the drug release behavior of the DOX-loaded materials at high pH (7.4) and low pH (5.5) and studied the cytotoxicity on A549 cells. The experimental results indicated that the drug delivery system can better control drug release and have potential applications in the drug delivery field.

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