808 nm near-infrared light controlled dual-drug release and cancer therapy in vivo by upconversion mesoporous silica nanostructures

2017 ◽  
Vol 5 (11) ◽  
pp. 2086-2095 ◽  
Author(s):  
Yunlu Dai ◽  
Huiting Bi ◽  
Xiaoran Deng ◽  
Chunxia Li ◽  
Fei He ◽  
...  
Keyword(s):  
Drug Release ◽  
Near Infrared ◽  
Infrared Light ◽  
Anticancer Efficacy ◽  
Control Drug ◽  
Silica Nanostructures ◽  
Controlled Release System ◽  
Control Drug Release ◽  
Dual Drug

A dual-drug co-delivery and 808 nm NIR photo-controlled release system can control drug release behaviour and enhance anticancer efficacy.

Emulsifying performance of near-infrared light responsive polydopamine-based silica particles to control drug release

2020 ◽  
Vol 359 ◽  
pp. 17-26 ◽  
Author(s):  
Sisi Li ◽  
Feng Wang ◽  
Zhouxiaoshuang Yang ◽  
Jun Xu ◽  
Hui Liu ◽  
...  
Keyword(s):  
Drug Release ◽  
Near Infrared ◽  
Silica Particles ◽  
Infrared Light ◽  
Near Infrared Light ◽  
Control Drug ◽  
Control Drug Release

Intracellular Self‐Immolative Polyprodrug with Near‐Infrared Light Guided Accumulation and in Vivo Visualization of Drug Release

2021 ◽  
pp. 2109528
Author(s):  
Dong‐Bing Cheng ◽  
Xue‐Hao Zhang ◽  
Si‐Yi Chen ◽  
Xiao‐Xue Xu ◽  
Hao Wang ◽  
...  
Keyword(s):  
Drug Release ◽  
Near Infrared ◽  
Infrared Light ◽  
Near Infrared Light

Biointerfacing polymeric microcapsules for in vivo near-infrared light-triggered drug release

Nanoscale ◽  
2015 ◽  
Vol 7 (45) ◽  
pp. 19092-19098 ◽  
Author(s):  
Jingxin Shao ◽  
Mingjun Xuan ◽  
Tieyan Si ◽  
Luru Dai ◽  
Qiang He
Keyword(s):  
Drug Release ◽  
Near Infrared ◽  
Infrared Light ◽  
Near Infrared Light ◽  
Triggered Drug Release ◽  
Polymeric Microcapsules

Doxorubicin release by magnetic inductive heating and in vivo hyperthermia-chemotherapy combined cancer treatment of multifunctional magnetic nanoparticles

2019 ◽  
Vol 43 (14) ◽  
pp. 5404-5413 ◽  
Author(s):  
Phuong Thu Ha ◽  
Thi Thu Huong Le ◽  
Thuc Quang Bui ◽  
Hong Nam Pham ◽  
Anh Son Ho ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Drug Release ◽  
Cancer Treatment ◽  
Treatment Efficacy ◽  
Inductive Heating ◽  
Control Drug ◽  
Doxorubicin Release ◽  
Control Drug Release

Multifunctional nanosystems help to control drug release and highly improve the cancer treatment efficacy in in vivo models.

Fluorescent proteins for in vivo imaging, where's the biliverdin?

2020 ◽  
Vol 48 (6) ◽  
pp. 2657-2667
Author(s):  
Felipe Montecinos-Franjola ◽  
John Y. Lin ◽  
Erik A. Rodriguez
Keyword(s):  
Hydrogen Peroxide ◽  
In Vivo Imaging ◽  
Near Infrared ◽  
Fluorescent Protein ◽  
Fluorescent Proteins ◽  
Fluorescent Imaging ◽  
Infrared Light ◽  
Red Fluorescent Protein ◽  
Color Palette

Noninvasive fluorescent imaging requires far-red and near-infrared fluorescent proteins for deeper imaging. Near-infrared light penetrates biological tissue with blood vessels due to low absorbance, scattering, and reflection of light and has a greater signal-to-noise due to less autofluorescence. Far-red and near-infrared fluorescent proteins absorb light >600 nm to expand the color palette for imaging multiple biosensors and noninvasive in vivo imaging. The ideal fluorescent proteins are bright, photobleach minimally, express well in the desired cells, do not oligomerize, and generate or incorporate exogenous fluorophores efficiently. Coral-derived red fluorescent proteins require oxygen for fluorophore formation and release two hydrogen peroxide molecules. New fluorescent proteins based on phytochrome and phycobiliproteins use biliverdin IXα as fluorophores, do not require oxygen for maturation to image anaerobic organisms and tumor core, and do not generate hydrogen peroxide. The small Ultra-Red Fluorescent Protein (smURFP) was evolved from a cyanobacterial phycobiliprotein to covalently attach biliverdin as an exogenous fluorophore. The small Ultra-Red Fluorescent Protein is biophysically as bright as the enhanced green fluorescent protein, is exceptionally photostable, used for biosensor development, and visible in living mice. Novel applications of smURFP include in vitro protein diagnostics with attomolar (10−18 M) sensitivity, encapsulation in viral particles, and fluorescent protein nanoparticles. However, the availability of biliverdin limits the fluorescence of biliverdin-attaching fluorescent proteins; hence, extra biliverdin is needed to enhance brightness. New methods for improved biliverdin bioavailability are necessary to develop improved bright far-red and near-infrared fluorescent proteins for noninvasive imaging in vivo.

Microencapsulation and Nanoencapsulation: A Review

2017 ◽  
Vol 9 (3) ◽  
Author(s):  
V. Suganya ◽  
V. Anuradha
Keyword(s):  
Drug Release ◽  
New Technology ◽  
Inert Material ◽  
Food Industries ◽  
Control Drug ◽  
Advantages And Disadvantages ◽  
Nano Scale ◽  
Pharmaceutical Industries ◽  
The Difference ◽  
Control Drug Release

Encapsulation is a process of enclosing the substances within an inert material which protects from environment as well as control drug release. Recently, two type of encapsulation has been performed in several research. Nanoencapsulation is the coating of various substances within another material at sizes on the nano scale. Microencapsulation is similar to nanoencapsulation aside from it involving larger particles and having been done for a greater period of time than nanoencapsulation. Encapsulation is a new technology that has wide applications in pharmaceutical industries, agrochemical, food industries and cosmetics. In this review, the difference between micro and nano encapsulation has been explained. This article gives an overview of different methods and reason for encapsulation. The advantages and disadvantages of micro and nano encapsulation technology were also clearly mentioned in this paper.

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