scholarly journals Nanoscale lipid vesicles functionalized with a nitro-aniline derivative for photoinduced nitric oxide (NO) delivery

2020 ◽  
Vol 2 (1) ◽  
pp. 463-469
Author(s):  
Nancy Sharma ◽  
Ajay Kumar Dhyani ◽  
Srujan Marepally ◽  
D. Amilan Jose
Keyword(s):  
Nitric Oxide ◽  
Lipid Vesicles ◽  
Aniline Derivative ◽  
Nano Scale ◽  
Controllable Release

Photo-controllable, non-toxic and bio-compatible nano-scale vesicles for the controllable release of nitric oxide (NO) have been reported.

scholarly journals A light-induced nitric oxide controllable release nano-platform based on diketopyrrolopyrrole derivatives for pH-responsive photodynamic/photothermal synergistic cancer therapy

2018 ◽  
Vol 9 (42) ◽  
pp. 8103-8109 ◽  
Author(s):  
Ya Wang ◽  
Xiaoyu Huang ◽  
Yunyun Tang ◽  
Jianhua Zou ◽  
Peng Wang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Tumor Microenvironment ◽  
Cancer Therapy ◽  
Ph Responsive ◽  
Controllable Release

An intelligent multifunctional nano-platform responsive to the tumor microenvironment was established, which showed NO controllable “on–off” release and enhanced photodynamic/photothermal synergistic cancer therapy.

Controllable release of nitric oxide and doxorubicin from engineered nanospheres for synergistic tumor therapy

2017 ◽  
Vol 57 ◽  
pp. 498-510 ◽  
Author(s):  
Lianjiang Tan ◽  
Ran Huang ◽  
Xiaoqiang Li ◽  
Shuiping Liu ◽  
Yu-Mei Shen
Keyword(s):  
Nitric Oxide ◽  
Tumor Therapy ◽  
Controllable Release

scholarly journals Synthesis and Characterization of Controlled Nitric Oxide Release from S-Nitroso-N-Acetyl-d-Penicillamine Covalently Linked to Polyvinyl Chloride (SNAP-PVC)

2018 ◽  
Vol 5 (3) ◽  
pp. 72 ◽  
Author(s):  
Sean Hopkins ◽  
Megan Frost
Keyword(s):  
Nitric Oxide ◽  
Inflammatory Response ◽  
Polyvinyl Chloride ◽  
Light Emitting ◽  
Nitric Oxide Release ◽  
Passive Mechanism ◽  
Controllable Release ◽  
Covalently Linked ◽  
Nitric Oxide Releasing

Polyvinyl chloride (PVC) is one of the most widely used polymers in medicine but has very poor biocompatibility when in contact with tissue or blood. To increase biocompatibility, controlled release of nitric oxide (NO) can be utilized to mitigate and reduce the inflammatory response. A synthetic route is described where PVC is aminated to a specified degree and then further modified by covalently linking S-nitroso-N-acetyl-d-penicillamine (SNAP) groups to the free primary amine sites to create a nitric oxide releasing polymer (SNAP-PVC). Controllable release of NO from SNAP-PVC is described using photoinitiation from light emitting diodes (LEDs). Ion-mediated NO release is also demonstrated as another pathway to provide a passive mechanism for NO delivery. The large range of NO fluxes obtained from the SNAP-PVC films indicate many potential uses in mediating unwanted inflammatory response in blood- and tissue-contacting devices and as a tool for delivering precise amounts of NO in vitro.

scholarly journals Cyanocobalamin Ultraflexible Lipid Vesicles: Characterization and In Vitro Evaluation of Drug-Skin Depth Profiles

Pharmaceutics ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 418
Author(s):  
Antonio José Guillot ◽  
Enrique Jornet-Mollá ◽  
Natalia Landsberg ◽  
Carmen Milián-Guimerá ◽  
M. Carmen Montesinos ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Vitamin B12 ◽  
Skin Diseases ◽  
Effective Diffusion ◽  
Skin Penetration ◽  
Lipid Vesicles ◽  
Skin Depth ◽  
Lipid Vesicle ◽  
Molecular Weights

Atopic dermatitis (AD) and psoriasis are the most common chronic inflammatory skin disorders, which importantly affect the quality of life of patients who suffer them. Among other causes, nitric oxide has been reported as part of the triggering factors in the pathogenesis of both conditions. Cyanocobalamin (vitamin B12) has shown efficacy as a nitric oxide scavenger and some clinical trials have given positive outcomes in its use for treating skin pathologies. Passive skin diffusion is possible only for drugs with low molecular weights and intermediate lipophilicity. Unfortunately, the molecular weight and hydrophilicity of vitamin B12 do not predict its effective diffusion through the skin. The aim of this work was to design new lipid vesicles to encapsulate the vitamin B12 to enhance its skin penetration. Nine prototypes of vesicles were generated and characterized in terms of size, polydispersity, surface charge, drug encapsulation, flexibility, and stability with positive results. Additionally, their ability to release the drug content in a controlled manner was demonstrated. Finally, we found that these lipid vesicle formulations facilitated the penetration of cyanocobalamin to the deeper layers of the skin. The present work shows a promising system to effectively administer vitamin B12 topically, which could be of interest in the treatment of skin diseases such as AD and psoriasis.

SERS Study of the Controllable Release of Nitric Oxide from Aromatic Nitrosothiols on Bimetallic, Bifunctional Nanoparticles Supported on Carbon Nanotubes

2008 ◽  
Vol 1 (1) ◽  
pp. 56-59 ◽  
Author(s):  
Patricia Taladriz-Blanco ◽  
Laura Rodríguez-Lorenzo ◽  
Marcos Sanles-Sobrido ◽  
Pablo Hervés ◽  
Miguel A. Correa-Duarte ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Carbon Nanotubes ◽  
Controllable Release

The structure of membranes and membrane proteins embedded in amorphous ice

1992 ◽  
Vol 50 (1) ◽  
pp. 432-433
Author(s):  
Uwe Lücken ◽  
Joachim Jäger
Keyword(s):  
Phase Transition ◽  
Transition Temperature ◽  
Membrane Proteins ◽  
Phase Transition Temperature ◽  
Lipid Vesicles ◽  
Freezing Stress ◽  
Amorphous Ice ◽  
Different Temperatures ◽  
Band Pass ◽  
Lipid Polymorphism

TEM imaging of frozen-hydrated lipid vesicles has been done by several groups Thermotrophic and lyotrophic polymorphism has been reported. By using image processing, computer simulation and tilt experiments, we tried to learn about the influence of freezing-stress and defocus artifacts on the lipid polymorphism and fine structure of the bilayer profile. We show integrated membrane proteins do modulate the bilayer structure and the morphology of the vesicles.Phase transitions of DMPC vesicles were visualized after freezing under equilibrium conditions at different temperatures in a controlled-environment vitrification system. Below the main phase transition temperature of 24°C (Fig. 1), vesicles show a facetted appearance due to the quasicrystalline areas. A gradual increase in temperature leads to melting processes with different morphology in the bilayer profile. Far above the phase transition temperature the bilayer profile is still present. In the band-pass-filtered images (Fig. 2) no significant change in the width of the bilayer profile is visible.

Localization of endothelial nitric oxide synthase in the normal and failing human atrial myocardium

1996 ◽  
Vol 54 ◽  
pp. 786-787
Author(s):  
Chi-Ming Wei ◽  
Margarita Bracamonte ◽  
Shi-Wen Jiang ◽  
Richard C. Daly ◽  
Christopher G.A. McGregor ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Heart Failure ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Cardiac Tissues ◽  
Mammalian Tissues ◽  
End Stage Heart Failure ◽  
End Stage ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

Nitric oxide (NO) is a potent endothelium-derived relaxing factor which also may modulate cardiomyocyte inotropism and growth via increasing cGMP. While endothelial nitric oxide synthase (eNOS) isoforms have been detected in non-human mammalian tissues, expression and localization of eNOS in the normal and failing human myocardium are poorly defined. Therefore, the present study was designed to investigate eNOS in human cardiac tissues in the presence and absence of congestive heart failure (CHF).Normal and failing atrial tissue were obtained from six cardiac donors and six end-stage heart failure patients undergoing primary cardiac transplantation. ENOS protein expression and localization was investigated utilizing Western blot analysis and immunohistochemical staining with the polyclonal rabbit antibody to eNOS (Transduction Laboratories, Lexington, Kentucky).

Nitric Oxide Reduces Pressor Responsiveness During Ovine Hypoadrenocorticism

2001 ◽  
Vol 28 (5-6) ◽  
pp. 459-462
Author(s):  
Pini Orbach ◽  
Charles E Wood ◽  
Maureen Keller-Wood
Keyword(s):  
Nitric Oxide
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