scholarly journals A light-induced nitric oxide controllable release nano-platform based on diketopyrrolopyrrole derivatives for pH-responsive photodynamic/photothermal synergistic cancer therapy

2018 ◽  
Vol 9 (42) ◽  
pp. 8103-8109 ◽  
Author(s):  
Ya Wang ◽  
Xiaoyu Huang ◽  
Yunyun Tang ◽  
Jianhua Zou ◽  
Peng Wang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Tumor Microenvironment ◽  
Cancer Therapy ◽  
Ph Responsive ◽  
Controllable Release

An intelligent multifunctional nano-platform responsive to the tumor microenvironment was established, which showed NO controllable “on–off” release and enhanced photodynamic/photothermal synergistic cancer therapy.

A tumor microenvironment (TME)-responsive nanoplatform for systemic saporin delivery and effective breast cancer therapy

2021 ◽  
Author(s):  
Qian Shen ◽  
Lei Xu ◽  
Rong Li ◽  
Guang Wu ◽  
Senlin Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Microenvironment ◽  
Cancer Therapy ◽  
Tumor Growth ◽  
Intracellular Delivery ◽  
Ph Responsive ◽  
Breast Cancer Therapy ◽  
Effective Inhibition ◽  
Inhibition Of Tumor Growth

A robust TME pH-responsive nanoplatform was herein developed. This nanoplatform could significantly improve intracellular delivery of cytotoxic saporin to achieve an effective inhibition of tumor growth of breast cancer.

scholarly journals Targeting the Ubiquitin Signaling Cascade in Tumor Microenvironment for Cancer Therapy

2021 ◽  
Vol 22 (2) ◽  
pp. 791
Author(s):  
Qi Liu ◽  
Bayonle Aminu ◽  
Olivia Roscow ◽  
Wei Zhang
Keyword(s):  
Tumor Microenvironment ◽  
Cancer Therapy ◽  
Therapeutic Agents ◽  
Biological Processes ◽  
Post Translational Modification ◽  
E3 Ligases ◽  
Tumor Microenvironments ◽  
Cellular Immune ◽  
Ubiquitin Conjugating Enzymes ◽  
Cellular Components

Tumor microenvironments are composed of a myriad of elements, both cellular (immune cells, cancer-associated fibroblasts, mesenchymal stem cells, etc.) and non-cellular (extracellular matrix, cytokines, growth factors, etc.), which collectively provide a permissive environment enabling tumor progression. In this review, we focused on the regulation of tumor microenvironment through ubiquitination. Ubiquitination is a reversible protein post-translational modification that regulates various key biological processes, whereby ubiquitin is attached to substrates through a catalytic cascade coordinated by multiple enzymes, including E1 ubiquitin-activating enzymes, E2 ubiquitin-conjugating enzymes and E3 ubiquitin ligases. In contrast, ubiquitin can be removed by deubiquitinases in the process of deubiquitination. Here, we discuss the roles of E3 ligases and deubiquitinases as modulators of both cellular and non-cellular components in tumor microenvironment, providing potential therapeutic targets for cancer therapy. Finally, we introduced several emerging technologies that can be utilized to develop effective therapeutic agents for targeting tumor microenvironment.

Targeting HDL in tumor microenvironment: New hope for cancer therapy

2021 ◽  
Author(s):  
Tan‐Jun Zhao ◽  
Neng Zhu ◽  
Ya‐Ning Shi ◽  
Yu‐Xiang Wang ◽  
Chan‐Juan Zhang ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Cancer Therapy

scholarly journals pH-responsive antibodies for therapeutic applications

2021 ◽  
Vol 28 (1) ◽  
Author(s):  
Tomasz Klaus ◽  
Sameer Deshmukh
Keyword(s):  
Drug Delivery ◽  
Treatment Outcome ◽  
Tumor Microenvironment ◽  
Dependent Manner ◽  
Therapeutic Antibodies ◽  
Ph Responsive ◽  
Biologic Drugs ◽  
Car T ◽  
Ph Dependent ◽  
The Brain

AbstractTherapeutic antibodies are instrumental in improving the treatment outcome for certain disease conditions. However, to enhance their efficacy and specificity, many efforts are continuously made. One of the approaches that are increasingly explored in this field are pH-responsive antibodies capable of binding target antigens in a pH-dependent manner. We reviewed suitability and examples of these antibodies that are functionally modulated by the tumor microenvironment. Provided in this review is an update about antigens targeted by pH-responsive, sweeping, and recycling antibodies. Applicability of the pH-responsive antibodies in the engineering of chimeric antigen receptor T-cells (CAR-T) and in improving drug delivery to the brain by the enhanced crossing of the blood–brain barrier is also discussed. The pH-responsive antibodies possess strong treatment potential. They emerge as next-generation programmable engineered biologic drugs that are active only within the targeted biological space. Thus, they are valuable in targeting acidified tumor microenvironment because of improved spatial persistence and reduced on-target off-tumor toxicities. We predict that the programmable pH-dependent antibodies become powerful tools in therapies of cancer.

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