Copper complexes of synthetic peptides mimicking neurotrophin-3 enhance neurite outgrowth and CREB phosphorylation

Metallomics ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 1567-1578 ◽  
Author(s):  
Irina Naletova ◽  
Giuseppa Ida Grasso ◽  
Cristina Satriano ◽  
Alessio Travaglia ◽  
Diego La Mendola ◽  
...  
Keyword(s):  
Neurite Outgrowth ◽  
Synthetic Peptides ◽  
Copper Complexes ◽  
Creb Phosphorylation ◽  
Neurotrophin 3 ◽  
Enhance Neurite Outgrowth

The copper(ii) complexes with peptide NT3(1–13) encompassing the first thirteen residues of the NT-3 protein induce neurite outgrowth and CREB phosphorylation.

scholarly journals Identification of a neurite outgrowth-promoting domain of laminin using synthetic peptides

FEBS Letters ◽  
1989 ◽  
Vol 244 (1) ◽  
pp. 141-148 ◽  
Author(s):  
Päivi Liesi ◽  
Ale Närvänen ◽  
Joszef Soos ◽  
Hannu Sariola ◽  
Georges Snounou
Keyword(s):  
Neurite Outgrowth ◽  
Synthetic Peptides

scholarly journals CaMKII-Mediated CREB Phosphorylation Is Involved in Ca2+-Induced BDNF mRNA Transcription and Neurite Outgrowth Promoted by Electrical Stimulation

PLoS ONE ◽  
2016 ◽  
Vol 11 (9) ◽  
pp. e0162784 ◽  
Author(s):  
Xiaodong Yan ◽  
Juanfang Liu ◽  
Zhengxu Ye ◽  
Jinghui Huang ◽  
Fei He ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Neurite Outgrowth ◽  
Mrna Transcription ◽  
Bdnf Mrna ◽  
Creb Phosphorylation

scholarly journals Biomimetic surface delivery of NGF and BDNF to enhance neurite outgrowth

2020 ◽  
Vol 117 (10) ◽  
pp. 3124-3135
Author(s):  
Ana M. Sandoval‐Castellanos ◽  
Frederik Claeyssens ◽  
John W. Haycock
Keyword(s):  
Neurite Outgrowth ◽  
Biomimetic Surface ◽  
Enhance Neurite Outgrowth

Neurotrophin-3 enhances neurite outgrowth in cultured hippocampal pyramidal neurons

1994 ◽  
Vol 39 (2) ◽  
pp. 219-232 ◽  
Author(s):  
G. Morfini ◽  
M. C. Ditella ◽  
F. Feiguin ◽  
N. Carri ◽  
A. Cáceres
Keyword(s):  
Neurite Outgrowth ◽  
Pyramidal Neurons ◽  
Hippocampal Pyramidal Neurons ◽  
Neurotrophin 3

The effect of polypyrrole with incorporated neurotrophin-3 on the promotion of neurite outgrowth from auditory neurons

Biomaterials ◽  
2007 ◽  
Vol 28 (3) ◽  
pp. 513-523 ◽  
Author(s):  
Rachael T. Richardson ◽  
Brianna Thompson ◽  
Simon Moulton ◽  
Carrie Newbold ◽  
May Ghee Lum ◽  
...  
Keyword(s):  
Neurite Outgrowth ◽  
Auditory Neurons ◽  
Neurotrophin 3

scholarly journals Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival

2008 ◽  
Vol 181 (1) ◽  
pp. 37-41 ◽  
Author(s):  
Philip Van Damme ◽  
Annelies Van Hoecke ◽  
Diether Lambrechts ◽  
Peter Vanacker ◽  
Elke Bogaert ◽  
...  
Keyword(s):  
Nervous System ◽  
Neurite Outgrowth ◽  
Neurotrophic Factor ◽  
Neuronal Survival ◽  
Cultured Neurons ◽  
Motor Neuron Degeneration ◽  
Neuron Degeneration ◽  
Protein Levels ◽  
The Central Nervous System ◽  
Enhance Neurite Outgrowth

Recently, mutations in the progranulin (PGRN) gene were found to cause familial and apparently sporadic frontotemporal lobe dementia (FTLD). Moreover, missense changes in PGRN were identified in patients with motor neuron degeneration, a condition that is related to FTLD. Most mutations identified in patients with FTLD until now have been null mutations. However, it remains unknown whether PGRN protein levels are reduced in the central nervous system from such patients. The effects of PGRN on neurons also remain to be established. We report that PGRN levels are reduced in the cerebrospinal fluid from FTLD patients carrying a PGRN mutation. We observe that PGRN and GRN E (one of the proteolytic fragments of PGRN) promote neuronal survival and enhance neurite outgrowth in cultured neurons. These results demonstrate that PGRN/GRN is a neurotrophic factor with activities that may be involved in the development of the nervous system and in neurodegeneration.

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