scholarly journals Biomimetic surface delivery of NGF and BDNF to enhance neurite outgrowth

2020 ◽  
Vol 117 (10) ◽  
pp. 3124-3135
Author(s):  
Ana M. Sandoval‐Castellanos ◽  
Frederik Claeyssens ◽  
John W. Haycock
Keyword(s):  
Neurite Outgrowth ◽  
Biomimetic Surface ◽  
Enhance Neurite Outgrowth

scholarly journals Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival

2008 ◽  
Vol 181 (1) ◽  
pp. 37-41 ◽  
Author(s):  
Philip Van Damme ◽  
Annelies Van Hoecke ◽  
Diether Lambrechts ◽  
Peter Vanacker ◽  
Elke Bogaert ◽  
...  
Keyword(s):  
Nervous System ◽  
Neurite Outgrowth ◽  
Neurotrophic Factor ◽  
Neuronal Survival ◽  
Cultured Neurons ◽  
Motor Neuron Degeneration ◽  
Neuron Degeneration ◽  
Protein Levels ◽  
The Central Nervous System ◽  
Enhance Neurite Outgrowth

Recently, mutations in the progranulin (PGRN) gene were found to cause familial and apparently sporadic frontotemporal lobe dementia (FTLD). Moreover, missense changes in PGRN were identified in patients with motor neuron degeneration, a condition that is related to FTLD. Most mutations identified in patients with FTLD until now have been null mutations. However, it remains unknown whether PGRN protein levels are reduced in the central nervous system from such patients. The effects of PGRN on neurons also remain to be established. We report that PGRN levels are reduced in the cerebrospinal fluid from FTLD patients carrying a PGRN mutation. We observe that PGRN and GRN E (one of the proteolytic fragments of PGRN) promote neuronal survival and enhance neurite outgrowth in cultured neurons. These results demonstrate that PGRN/GRN is a neurotrophic factor with activities that may be involved in the development of the nervous system and in neurodegeneration.

P4 -ATPase ATP8A2 acts in synergy with CDC50A to enhance neurite outgrowth

FEBS Letters ◽  
2012 ◽  
Vol 586 (13) ◽  
pp. 1803-1812 ◽  
Author(s):  
Qin Xu ◽  
Guo-Ying Yang ◽  
Na Liu ◽  
Peng Xu ◽  
Yue-Lei Chen ◽  
...  
Keyword(s):  
Neurite Outgrowth ◽  
Enhance Neurite Outgrowth

scholarly journals Enhancement of Neurite Outgrowth by Warming Biomaterial Ultrasound Treatment

2020 ◽  
Vol 21 (6) ◽  
pp. 2236 ◽  
Author(s):  
Jung-Chih Chen ◽  
Chao-Ming Su ◽  
Gin-Shin Chen ◽  
Chin-Chun Lai ◽  
Ching-Yun Chen ◽  
...  
Keyword(s):  
Neurite Outgrowth ◽  
Ultrasonic Treatment ◽  
Treatment Time ◽  
Fe3o4 Nanoparticle ◽  
Neuronal Function ◽  
Acoustic Attenuation ◽  
Working Temperature ◽  
Time Treatment ◽  
Long Time ◽  
Enhance Neurite Outgrowth

Ultrasound is a method for enhancing neurite outgrowth because of its thermal effect. In order to reach the working temperature to enhance neurite outgrowth, long-time treatment by ultrasound is necessary, while acknowledging that the treatment poses a high risk of damaging nerve cells. To overcome this problem, we developed a method that shortens the ultrasonic treatment time with a warming biomaterial. In this study, we used Fe3O4 nanoparticle-embedded polycaprolactone (PCL) as a sonosensitized biomaterial, which has an excellent heating rate due to its high acoustic attenuation. With this material, the ultrasonic treatment time for enhancing neurite outgrowth could be effectively shortened. Ultrasonic treatment could also increase neuronal function combined with the warming biomaterial, with more promoter neuronal function than only ultrasound. Moreover, the risk of overexposure can be avoided by the use of the warming biomaterial by reducing the ultrasonic treatment time, providing better effectiveness.

Copper complexes of synthetic peptides mimicking neurotrophin-3 enhance neurite outgrowth and CREB phosphorylation

Metallomics ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 1567-1578 ◽  
Author(s):  
Irina Naletova ◽  
Giuseppa Ida Grasso ◽  
Cristina Satriano ◽  
Alessio Travaglia ◽  
Diego La Mendola ◽  
...  
Keyword(s):  
Neurite Outgrowth ◽  
Synthetic Peptides ◽  
Copper Complexes ◽  
Creb Phosphorylation ◽  
Neurotrophin 3 ◽  
Enhance Neurite Outgrowth

The copper(ii) complexes with peptide NT3(1–13) encompassing the first thirteen residues of the NT-3 protein induce neurite outgrowth and CREB phosphorylation.

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