scholarly journals In situ non-invasive Raman spectroscopic characterisation of succinic acid polymorphism during segmented flow crystallisation

2020 ◽  
Vol 5 (1) ◽  
pp. 294-303 ◽  
Author(s):  
Anuradha R. Pallipurath ◽  
Pierre-Baptiste Flandrin ◽  
Lois E. Wayment ◽  
Chick C. Wilson ◽  
Karen Robertson
Keyword(s):  
Raman Spectroscopy ◽  
Crystal Growth ◽  
Succinic Acid ◽  
Segmented Flow ◽  
Confocal Raman Spectroscopy ◽  
Raman Spectroscopic ◽  
Non Invasive ◽  
Confocal Raman ◽  
Spectroscopic Characterisation

Non-invasive confocal Raman spectroscopy has been integrated into a highly controllable tri-segmented flow crystallisation environment to uncover the crystallisation pathway from nucleation to crystal growth of the polymorphic compound succinic acid.

Non-invasive analysis of hormonal variations and effect of postmenopausal Vagifem treatment on women using in vivo high wavenumber confocal Raman spectroscopy

The Analyst ◽  
2013 ◽  
Vol 138 (14) ◽  
pp. 4120 ◽  
Author(s):  
Shiyamala Duraipandian ◽  
Wei Zheng ◽  
Joseph Ng ◽  
Jeffrey J. H. Low ◽  
A. Ilancheran ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Confocal Raman Spectroscopy ◽  
Non Invasive ◽  
Confocal Raman

scholarly journals Confocal Raman spectroscopy: Evaluation of a non-invasive technique for the detection of topically applied ketorolac tromethamine in vitro and in vivo

2019 ◽  
Vol 570 ◽  
pp. 118641 ◽  
Author(s):  
Christian J.F. Bertens ◽  
Shuo Zhang ◽  
Roel J. Erckens ◽  
Frank J.H.M. van den Biggelaar ◽  
Tos T.J.M. Berendschot ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Invasive Technique ◽  
Ketorolac Tromethamine ◽  
Confocal Raman Spectroscopy ◽  
Non Invasive ◽  
Confocal Raman

In situ analysis of water management in operating fuel cells by confocal Raman spectroscopy

2011 ◽  
Vol 13 (5) ◽  
pp. 418-422 ◽  
Author(s):  
P. Huguet ◽  
A. Morin ◽  
G. Gebel ◽  
S. Deabate ◽  
A.K. Sutor ◽  
...  
Keyword(s):  
Water Management ◽  
Raman Spectroscopy ◽  
Fuel Cells ◽  
In Situ Analysis ◽  
Confocal Raman Spectroscopy ◽  
Confocal Raman

Drug-induced corneal hydration changes monitoredin vivo by non-invasive confocal Raman spectroscopy

2001 ◽  
Vol 32 (9) ◽  
pp. 733-737 ◽  
Author(s):  
Roel J. Erckens ◽  
Franciscus H. M. Jongsma ◽  
James P. Wicksted ◽  
Fred Hendrikse ◽  
Wayne F. March ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Confocal Raman Spectroscopy ◽  
Drug Induced ◽  
Corneal Hydration ◽  
Non Invasive ◽  
Confocal Raman

scholarly journals In-Line and Off-Line Monitoring of Skin Penetration Profiles Using Confocal Raman Spectroscopy

Pharmaceutics ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 67
Author(s):  
Richard Krombholz ◽  
Yali Liu ◽  
Dominique Jasmin Lunter
Keyword(s):  
Raman Spectroscopy ◽  
Ex Vivo ◽  
Skin Penetration ◽  
Confocal Raman Spectroscopy ◽  
Line Measurement ◽  
Lauryl Ether ◽  
Confocal Raman ◽  
Ex Vivo Study

Ex-vivo and in-vivo skin analysis has been extensively evaluated by confocal Raman spectroscopy (CRS). The off-line measurement with a CRS-suited skin-mounted device after Franz-cell incubations is the most popular choice. However, real-time monitoring of in-line measurement has clear advantages for obtaining dynamic and more timely results. In our study, a custom-built setup suitable for in-line measurements was implemented, which ensures constant skin incubation and in-situ skin detections. We aim to compare the differences between using in-line and off-line devices for monitoring skin drug penetrations. A well-assessed formulation gel with procaine-HCl as the active ingredient was used as reference. The PEG-23 lauryl ether was added to the formulation as a penetration enhancer to evaluate the enhancement effects of procaine on skin. After incubation times of 14, 20, and 24 h, skin penetration profiles were assessed. Comparable results between off-line and in-line measurements were obtained. Remarkable improvements in penetrated procaine amount and depth were observed. Based on the significant differences of their enhanced penetration amounts, fairly similar estimations were achieved from both methods. A slight difference of 14 h incubation between these two setups can still be found, which may be due to the different detection conditions and affected skin properties. Overall, in-line measurements could provide a more time- and labor-saving alternative for off-line measurements in ex-vivo study.

Physical and compositional analysis of differently cultured 3D human skin equivalents by confocal Raman spectroscopy

The Analyst ◽  
2018 ◽  
Vol 143 (5) ◽  
pp. 1065-1076 ◽  
Author(s):  
Y. Dancik ◽  
G. Sriram ◽  
B. Rout ◽  
Y. Zou ◽  
M. Bigliardi-Qi ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Human Skin ◽  
Compositional Analysis ◽  
Culture Conditions ◽  
Confocal Raman Spectroscopy ◽  
Non Invasive ◽  
Skin Equivalents ◽  
Confocal Raman

Confocal Raman spectroscopy is an effective method for non-invasive discrimination of 3D human skin equivalents grown under different culture conditions.

Non-Invasive Assessment of Ocular Pharmacokinetics Using Confocal Raman Spectroscopy

1999 ◽  
Vol 15 (2) ◽  
pp. 123-134 ◽  
Author(s):  
NOËL J.C. BAUER ◽  
MASSOUD MOTAMEDI ◽  
JAMES P. WICKSTED ◽  
WAYNE F. MARCH ◽  
CARROL A.B. WEBERS ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Ocular Pharmacokinetics ◽  
Confocal Raman Spectroscopy ◽  
Non Invasive ◽  
Confocal Raman
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