In Situ Studies of the Mass Transfer Mechanism across a Methane Hydrate Film Using High-Resolution Confocal Raman Spectroscopy

2009 ◽  
Vol 114 (2) ◽  
pp. 1173-1180 ◽  
Author(s):  
Simon R. Davies ◽  
E. Dendy Sloan ◽  
Amadeu K. Sum ◽  
Carolyn A. Koh
Keyword(s):  
Mass Transfer ◽  
Raman Spectroscopy ◽  
High Resolution ◽  
Methane Hydrate ◽  
Confocal Raman Spectroscopy ◽  
In Situ Studies ◽  
Mass Transfer Mechanism ◽  
Hydrate Film ◽  
Confocal Raman

In situ analysis of water management in operating fuel cells by confocal Raman spectroscopy

2011 ◽  
Vol 13 (5) ◽  
pp. 418-422 ◽  
Author(s):  
P. Huguet ◽  
A. Morin ◽  
G. Gebel ◽  
S. Deabate ◽  
A.K. Sutor ◽  
...  
Keyword(s):  
Water Management ◽  
Raman Spectroscopy ◽  
Fuel Cells ◽  
In Situ Analysis ◽  
Confocal Raman Spectroscopy ◽  
Confocal Raman

scholarly journals In-Line and Off-Line Monitoring of Skin Penetration Profiles Using Confocal Raman Spectroscopy

Pharmaceutics ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 67
Author(s):  
Richard Krombholz ◽  
Yali Liu ◽  
Dominique Jasmin Lunter
Keyword(s):  
Raman Spectroscopy ◽  
Ex Vivo ◽  
Skin Penetration ◽  
Confocal Raman Spectroscopy ◽  
Line Measurement ◽  
Lauryl Ether ◽  
Confocal Raman ◽  
Ex Vivo Study

Ex-vivo and in-vivo skin analysis has been extensively evaluated by confocal Raman spectroscopy (CRS). The off-line measurement with a CRS-suited skin-mounted device after Franz-cell incubations is the most popular choice. However, real-time monitoring of in-line measurement has clear advantages for obtaining dynamic and more timely results. In our study, a custom-built setup suitable for in-line measurements was implemented, which ensures constant skin incubation and in-situ skin detections. We aim to compare the differences between using in-line and off-line devices for monitoring skin drug penetrations. A well-assessed formulation gel with procaine-HCl as the active ingredient was used as reference. The PEG-23 lauryl ether was added to the formulation as a penetration enhancer to evaluate the enhancement effects of procaine on skin. After incubation times of 14, 20, and 24 h, skin penetration profiles were assessed. Comparable results between off-line and in-line measurements were obtained. Remarkable improvements in penetrated procaine amount and depth were observed. Based on the significant differences of their enhanced penetration amounts, fairly similar estimations were achieved from both methods. A slight difference of 14 h incubation between these two setups can still be found, which may be due to the different detection conditions and affected skin properties. Overall, in-line measurements could provide a more time- and labor-saving alternative for off-line measurements in ex-vivo study.

scholarly journals In situ non-invasive Raman spectroscopic characterisation of succinic acid polymorphism during segmented flow crystallisation

2020 ◽  
Vol 5 (1) ◽  
pp. 294-303 ◽  
Author(s):  
Anuradha R. Pallipurath ◽  
Pierre-Baptiste Flandrin ◽  
Lois E. Wayment ◽  
Chick C. Wilson ◽  
Karen Robertson
Keyword(s):  
Raman Spectroscopy ◽  
Crystal Growth ◽  
Succinic Acid ◽  
Segmented Flow ◽  
Confocal Raman Spectroscopy ◽  
Raman Spectroscopic ◽  
Non Invasive ◽  
Confocal Raman ◽  
Spectroscopic Characterisation

Non-invasive confocal Raman spectroscopy has been integrated into a highly controllable tri-segmented flow crystallisation environment to uncover the crystallisation pathway from nucleation to crystal growth of the polymorphic compound succinic acid.

In situ confocal Raman spectroscopy of lubricants in a soft elastohydrodynamic tribological contact

2008 ◽  
Vol 104 (1) ◽  
pp. 014913 ◽  
Author(s):  
J. H. H. Bongaerts ◽  
J. P. R. Day ◽  
C. Marriott ◽  
P. D. A. Pudney ◽  
A.-M. Williamson
Keyword(s):  
Raman Spectroscopy ◽  
Confocal Raman Spectroscopy ◽  
Confocal Raman ◽  
Tribological Contact
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