The anti-diabetic effect of eight Lagerstroemia speciosa leaf extracts based on the contents of ellagitannins and ellagic acid derivatives

2020 ◽  
Vol 11 (2) ◽  
pp. 1560-1571 ◽  
Author(s):  
Sen Guo ◽  
Xiameng Ren ◽  
Kan He ◽  
Xiaozhuo Chen ◽  
Shanshan Zhang ◽  
...  
Keyword(s):  
Ellagic Acid ◽  
Manufacturing Processes ◽  
Leaf Extracts ◽  
Lagerstroemia Speciosa ◽  
Ellagic Acid Derivatives

Anti-diabetic effects of eight extracts from leaves of L. speciosa using different manufacturing processes based on the contents of active ellagitannins and inhibitory ellagic acid derivatives.

ChemInform Abstract: DNA Gyrase Inhibitory Activity of Ellagic Acid Derivatives.

ChemInform ◽  
2010 ◽  
Vol 29 (18) ◽  
pp. no-no
Author(s):  
M. A. WEIDNER-WELLS ◽  
J. ALTOM ◽  
J. FERNANDEZ ◽  
S. A. FRAGA-SPANO ◽  
J. HILLIARD ◽  
...  
Keyword(s):  
Ellagic Acid ◽  
Inhibitory Activity ◽  
Dna Gyrase ◽  
Ellagic Acid Derivatives

scholarly journals Cytotoxic and antioxidant potentials of ellagic acid derivatives from Conocarpus lancifolius (Combretaceae)

2020 ◽  
Vol 19 (5) ◽  
pp. 1037-1080
Author(s):  
Malik Saadullah ◽  
Muhammad Asif ◽  
Abdul Sattar ◽  
Kanwal Rehman ◽  
Shahid Shah ◽  
...  
Keyword(s):  
Ellagic Acid ◽  
Antioxidant Properties ◽  
Human Colon ◽  
Antioxidant Compounds ◽  
Phytochemical Analysis ◽  
Human Colon Cancer ◽  
Chemical Structures ◽  
Ellagic Acid Derivatives ◽  
Layer Chromatography

Purpose: Isolation, characterisation and structure elucidation of compounds obtained from Conocarpus lancifolius and screening of their pharmacological effects in vitro.Methods: After collection, authentication and extraction from whole C. lancifolius plants, screening for secondary metabolites, thin-layer  chromatography and subsequent open column chromatography were performed for phytochemical analysis and subsequent purification of the compounds. The chemical structures of the isolated compounds were elucidated using spectroscopic (UV-visible, infrared and mass) spectroscopy, and nuclear magnetic resonance (1H-NMR, 13C-NMR including BB, DEPT-135, 90 and two-dimensional correlation techniques, including HMBC and HSQC). The cytotoxic and antioxidant potentials of extracts and compounds obtained from C. lancifolius were evaluated using in vitro models.Results: Two ellagic acid derivatives, 2,3,8-tri-o-methylellagic acid (A) and 3-O-methylellagic acid 4-O-β-D-glucopyranoside (B), were isolated. Both compounds (A and B) were cytotoxic in a variety of cancer cell lines, including murine lymphocytic leukaemia (P-388, half-maximal inhibitory concentration (IC50) =3.60 and 2.40 μg/mL, respectively), human colon cancer (Col-2, IC50 = 0.76 and 0.92 μg/mL, respectively) and human breast cancer (MCF-7, IC50 = 0.65 and 0.54 μg/mL, respectively). Moreover, both compounds showed significant antioxidant potential in vitro.Conclusion: C. lancifolius extract and isolated ellagic acid derivatives (compounds A and B) possess cytotoxic and antioxidant properties. These findings suggest that C. lancifolius contains bioactive compounds that can be potentially developed as natural cytotoxic and antioxidant compounds. Keywords: Conocarpus lancifolius, Ellagic acid, Combretaceae, Cytotoxic activity, Antioxidant

scholarly journals Ellagic Acid Derivatives from Syzygium cumini Stem Bark: Investigation of their Antiplasmodial Activity

2009 ◽  
Vol 4 (10) ◽  
pp. 1934578X0900401 ◽  
Author(s):  
Claudia A. Simões-Pires ◽  
Sandra Vargas ◽  
Andrew Marston ◽  
Jean-Robert Ioset ◽  
Marçal Q. Paulo ◽  
...  
Keyword(s):  
Mechanism Of Action ◽  
Ellagic Acid ◽  
Stem Bark ◽  
Antimalarial Drugs ◽  
Antiplasmodial Activity ◽  
Hydroxyl Groups ◽  
Syzygium Cumini ◽  
Free Hydroxyl ◽  
Ellagic Acid Derivatives

Bioguided fractionation of Syzygium cumini (Myrtaceae) bark decoction for antiplasmodial activity was performed, leading to the isolation of three known ellagic acid derivatives (ellagic acid, ellagic acid 4-O-α-L-2″-acetylrhamnopyranoside, 3-O-methylellagic acid 3′-O-α-L-rhamnopyranoside), as well as the new derivative 3-O-methylellagic acid 3′-O-β-D-glucopyranoside. Activity investigation was based on the reduction of P. falciparum (PfK1) parasitaemia in vitro and the inhibition of β-hematin formation, a known mechanism of action of some antimalarial drugs. Among the investigated ellagic acid derivatives, only ellagic acid was able to reduce P. falciparum parasitaemia in vitro and inhibit β-hematin formation, suggesting that free hydroxyl groups are necessary for activity within this class of compounds.

New Antioxidant and Antimicrobial Ellagic Acid Derivatives from Pteleopsis hylodendron

Planta Medica ◽  
2001 ◽  
Vol 67 (4) ◽  
pp. 335-339 ◽  
Author(s):  
Atta-Ur-Rahman ◽  
F. N. Ngounou ◽  
M. Iqbal Choudhary ◽  
Shahid Malik ◽  
Talat Makhmoor ◽  
...  
Keyword(s):  
Ellagic Acid ◽  
Ellagic Acid Derivatives

ChemInform Abstract: Ellagic Acid Derivatives from the Leaves of Eugenia jambos Linn.

ChemInform ◽  
2010 ◽  
Vol 30 (25) ◽  
pp. no-no
Author(s):  
Ajit Kumar Chakravarty ◽  
Binayak Das ◽  
Tapas Sarkar ◽  
Kazuo Masuda ◽  
Kenji Shiojima
Keyword(s):  
Ellagic Acid ◽  
Ellagic Acid Derivatives

scholarly journals Anti-diabetic Effects of Banaba Leaf Extracts (Lagerstroemia speciosa Pers.) through Solvents

2008 ◽  
Vol 18 (9) ◽  
pp. 1305-1311 ◽  
Author(s):  
Kyun-Ha Kim ◽  
Sang-Geun Roh ◽  
Chun-Ri Li ◽  
Chun-Feng Jin ◽  
Andre Kim ◽  
...  
Keyword(s):  
Leaf Extracts ◽  
Lagerstroemia Speciosa
Sign in / Sign up

Export Citation Format

Share Document