ChemInform Abstract: DNA Gyrase Inhibitory Activity of Ellagic Acid Derivatives.

ChemInform ◽  
2010 ◽  
Vol 29 (18) ◽  
pp. no-no
Author(s):  
M. A. WEIDNER-WELLS ◽  
J. ALTOM ◽  
J. FERNANDEZ ◽  
S. A. FRAGA-SPANO ◽  
J. HILLIARD ◽  
...  
Keyword(s):  
Ellagic Acid ◽  
Inhibitory Activity ◽  
Dna Gyrase ◽  
Ellagic Acid Derivatives

DNA gyrase inhibitory activity of ellagic acid derivatives

1998 ◽  
Vol 8 (1) ◽  
pp. 97-100 ◽  
Author(s):  
Michele A Weidner-Wells ◽  
Jason Altom ◽  
Jeffrey Fernandez ◽  
Stephanie A Fraga-Spano ◽  
Jamese Hilliard ◽  
...  
Keyword(s):  
Ellagic Acid ◽  
Inhibitory Activity ◽  
Dna Gyrase ◽  
Ellagic Acid Derivatives

scholarly journals Cytotoxic and antioxidant potentials of ellagic acid derivatives from Conocarpus lancifolius (Combretaceae)

2020 ◽  
Vol 19 (5) ◽  
pp. 1037-1080
Author(s):  
Malik Saadullah ◽  
Muhammad Asif ◽  
Abdul Sattar ◽  
Kanwal Rehman ◽  
Shahid Shah ◽  
...  
Keyword(s):  
Ellagic Acid ◽  
Antioxidant Properties ◽  
Human Colon ◽  
Antioxidant Compounds ◽  
Phytochemical Analysis ◽  
Human Colon Cancer ◽  
Chemical Structures ◽  
Ellagic Acid Derivatives ◽  
Layer Chromatography

Purpose: Isolation, characterisation and structure elucidation of compounds obtained from Conocarpus lancifolius and screening of their pharmacological effects in vitro.Methods: After collection, authentication and extraction from whole C. lancifolius plants, screening for secondary metabolites, thin-layer  chromatography and subsequent open column chromatography were performed for phytochemical analysis and subsequent purification of the compounds. The chemical structures of the isolated compounds were elucidated using spectroscopic (UV-visible, infrared and mass) spectroscopy, and nuclear magnetic resonance (1H-NMR, 13C-NMR including BB, DEPT-135, 90 and two-dimensional correlation techniques, including HMBC and HSQC). The cytotoxic and antioxidant potentials of extracts and compounds obtained from C. lancifolius were evaluated using in vitro models.Results: Two ellagic acid derivatives, 2,3,8-tri-o-methylellagic acid (A) and 3-O-methylellagic acid 4-O-β-D-glucopyranoside (B), were isolated. Both compounds (A and B) were cytotoxic in a variety of cancer cell lines, including murine lymphocytic leukaemia (P-388, half-maximal inhibitory concentration (IC50) =3.60 and 2.40 μg/mL, respectively), human colon cancer (Col-2, IC50 = 0.76 and 0.92 μg/mL, respectively) and human breast cancer (MCF-7, IC50 = 0.65 and 0.54 μg/mL, respectively). Moreover, both compounds showed significant antioxidant potential in vitro.Conclusion: C. lancifolius extract and isolated ellagic acid derivatives (compounds A and B) possess cytotoxic and antioxidant properties. These findings suggest that C. lancifolius contains bioactive compounds that can be potentially developed as natural cytotoxic and antioxidant compounds. Keywords: Conocarpus lancifolius, Ellagic acid, Combretaceae, Cytotoxic activity, Antioxidant

scholarly journals Ellagic Acid Derivatives from Syzygium cumini Stem Bark: Investigation of their Antiplasmodial Activity

2009 ◽  
Vol 4 (10) ◽  
pp. 1934578X0900401 ◽  
Author(s):  
Claudia A. Simões-Pires ◽  
Sandra Vargas ◽  
Andrew Marston ◽  
Jean-Robert Ioset ◽  
Marçal Q. Paulo ◽  
...  
Keyword(s):  
Mechanism Of Action ◽  
Ellagic Acid ◽  
Stem Bark ◽  
Antimalarial Drugs ◽  
Antiplasmodial Activity ◽  
Hydroxyl Groups ◽  
Syzygium Cumini ◽  
Free Hydroxyl ◽  
Ellagic Acid Derivatives

Bioguided fractionation of Syzygium cumini (Myrtaceae) bark decoction for antiplasmodial activity was performed, leading to the isolation of three known ellagic acid derivatives (ellagic acid, ellagic acid 4-O-α-L-2″-acetylrhamnopyranoside, 3-O-methylellagic acid 3′-O-α-L-rhamnopyranoside), as well as the new derivative 3-O-methylellagic acid 3′-O-β-D-glucopyranoside. Activity investigation was based on the reduction of P. falciparum (PfK1) parasitaemia in vitro and the inhibition of β-hematin formation, a known mechanism of action of some antimalarial drugs. Among the investigated ellagic acid derivatives, only ellagic acid was able to reduce P. falciparum parasitaemia in vitro and inhibit β-hematin formation, suggesting that free hydroxyl groups are necessary for activity within this class of compounds.

New Antioxidant and Antimicrobial Ellagic Acid Derivatives from Pteleopsis hylodendron

Planta Medica ◽  
2001 ◽  
Vol 67 (4) ◽  
pp. 335-339 ◽  
Author(s):  
Atta-Ur-Rahman ◽  
F. N. Ngounou ◽  
M. Iqbal Choudhary ◽  
Shahid Malik ◽  
Talat Makhmoor ◽  
...  
Keyword(s):  
Ellagic Acid ◽  
Ellagic Acid Derivatives

ChemInform Abstract: Ellagic Acid Derivatives from the Leaves of Eugenia jambos Linn.

ChemInform ◽  
2010 ◽  
Vol 30 (25) ◽  
pp. no-no
Author(s):  
Ajit Kumar Chakravarty ◽  
Binayak Das ◽  
Tapas Sarkar ◽  
Kazuo Masuda ◽  
Kenji Shiojima
Keyword(s):  
Ellagic Acid ◽  
Ellagic Acid Derivatives

scholarly journals Pharmacokinetic properties of inhibitors to Histidine Decarboxylase isolated from fennel

2020 ◽  
Vol 11 (4) ◽  
pp. 6707-6714
Author(s):  
Sneha Bhatt ◽  
Gletta Anjaly C.T ◽  
Shlini P
Keyword(s):  
Mast Cell ◽  
Thin Layer ◽  
Ellagic Acid ◽  
Inhibitory Activity ◽  
Histidine Decarboxylase ◽  
Methanolic Extract ◽  
Mast Cell Degranulation ◽  
Pharmacokinetic Properties ◽  
Phytochemical Constituents ◽  
Layer Chromatography

Histamine release is involved in developing wakefulness and activation of cortex. The purpose of the study was to find an alternative to these antihistamines by inhibiting the enzyme histidine decarboxylase which is responsible for the production of histamine. Histamine brings about the allergic response due to mast cell degranulation. It is also necessary that the enzyme is not completely inhibited as it plays a role as a neurotransmitter and also regulates gastric acid secretion. In the present study, the methanolic extract of commercially available fennel seeds were examined for its inhibitory activity on the purified extract of bacterial histidine decarboxylase. The methanolic extract of fennel was analyzed to check the presence of various phytochemical constituents. The spice extract was quantified to estimate the presence of flavonoids. The extract was subjected to purification by thin layer chromatography and HPLC in order to isolate and identify the flavonoids present in spice extract. The HPLC results with reference to the standard indicated the presence of ellagic acid and quercetin. The spice extracts were subjected to inhibitory studies at increasing concentrations. The fennel extract at concentration of 0.625 moles was found to be inhibiting histidine decarboxylase which was determined using the Dixon plot. The identified flavonoids were then subjected to software’s like Molinspiration and Swiss ADME in order to study the molecular properties, drug likeliness and pharmacokinetics.

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