scholarly journals The effect of culinary doses of spices in a high-saturated fat, high-carbohydrate meal on postprandial lipemia and endothelial function: a randomized, controlled, crossover pilot trial

2020 ◽  
Vol 11 (4) ◽  
pp. 3191-3200
Author(s):  
Kristina S. Petersen ◽  
Connie J. Rogers ◽  
Sheila G. West ◽  
David N. Proctor ◽  
Penny M. Kris-Etherton
Keyword(s):  
Endothelial Function ◽  
Pilot Trial ◽  
Postprandial Lipemia ◽  
Saturated Fat ◽  
High Carbohydrate ◽  
Randomized Controlled ◽  
Carbohydrate Meal

Lower doses of spices (2 and 6 g) than previously tested may attenuate postprandial lipemia and impairments in endothelial function caused by a high-saturated fat, high-carbohydrate meal.

scholarly journals Spices in a High-Saturated-Fat, High-Carbohydrate Meal Reduce Postprandial Proinflammatory Cytokine Secretion in Men with Overweight or Obesity: A 3-Period, Crossover, Randomized Controlled Trial

2020 ◽  
Vol 150 (6) ◽  
pp. 1600-1609 ◽  
Author(s):  
Ester S Oh ◽  
Kristina S Petersen ◽  
Penny M Kris-Etherton ◽  
Connie J Rogers
Keyword(s):  
Randomized Controlled Trial ◽  
Risk Factor ◽  
Proinflammatory Cytokine ◽  
Mononuclear Cells ◽  
Controlled Trial ◽  
Saturated Fat ◽  
Cvd Risk ◽  
High Carbohydrate ◽  
Randomized Controlled ◽  
Carbohydrate Meal

ABSTRACT Background Postprandial inflammation that occurs concurrently with hyperglycemia and hyperlipidemia after ingestion of a high-saturated-fat, high-carbohydrate meal (HFCM) is a risk factor for cardiovascular disease (CVD). Numerous preclinical and clinical studies demonstrate anti-inflammatory effects of individual spices. However, the effect of consumption of a spice blend on inflammatory mediators has not been examined in a randomized controlled trial. Objectives The objective of this study was to investigate the postprandial effect of a blend of spices in a HFCM on inflammatory cytokine responses. Methods Nonsmoking men (40–65 y old) with overweight/obesity (25 ≤ BMI ≤ 35 kg/m2), elevated waist circumference (≥ 94 cm), and ≥ 1 CVD risk factor were recruited for a 3-period crossover study ( n = 12). In random order, participants consumed the following: a HFCM (∼1000 kcal, 33% kcal from saturated fat and 36% kcal from carbohydrate), a HFCM containing 2 g spice blend, or an HFCM containing 6 g spice blend. The spice blend consisted of basil, bay leaf, black pepper, cinnamon, coriander, cumin, ginger, oregano, parsley, red pepper, rosemary, thyme, and turmeric. Blood was collected before, and hourly for 4 h after the HFCM. Peripheral blood mononuclear cells (PBMCs) were isolated, and the percentage of CD14 +/Human Leukocyte Antigen-DR isotype + (HLA-DR +) monocytes and proinflammatory cytokine concentrations in plasma and LPS-stimulated PBMCs were quantified as secondary outcomes. Results There was a significant spice-by-time interaction on IL-1β (P < 0.001), IL-8 (P = 0.020), and TNF-α (P = 0.009) secretion from LPS-stimulated PBMCs. IL-1β secretion from LPS-stimulated PBMCs was significantly reduced (1314%) at 240 min after HFCM consumption containing 6 g, but not 2 g, of spice blend compared with 0 g spice blend. Conclusions A HFCM containing 6 g spice blend attenuated HFCM-induced postprandial IL-1β secretion in men with overweight/obesity. This trial was registered at clinicaltrials.gov as NCT03064958.

scholarly journals No Difference in Lipemic Response or Endothelial Function Following Interesterified and Non-Interesterified Functionally Equivalent Fats: A Randomized Controlled Trial

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 630-630
Author(s):  
Philippa Gibson ◽  
Maria D'Annibale ◽  
Aseel Alkoblan ◽  
Sarah Berry ◽  
Wendy Hall
Keyword(s):  
Endothelial Function ◽  
Oxidase Activity ◽  
Rapeseed Oil ◽  
Controlled Trial ◽  
Postprandial Lipemia ◽  
Solid Fat Content ◽  
Significant Treatment ◽  
Nadph Oxidase Activity ◽  
Solid Fat ◽  
Randomized Controlled

Abstract Objectives Interesterified (IE) fats are now used as hard fats to replace harmful trans fats, however the cardiometabolic health impact of the most commonly consumed IE fat blends are unknown. The InterCardio study (NCT03438084) investigated the effect of the most commonly consumed IE spread versus functionally equivalent hard fats and a control oil, on postprandial lipemia (PPL) and acutely changing markers of endothelial function. Methods A four-armed, double blind, randomized controlled trial in healthy males and females (n = 50) aged 35–75 years compared sequential test meals (0 h; 897 kcal, 50 g fat, 16 g protein, 88 g carbohydrate, 5 h; 550 kcal, 30 g fat, 15 g protein, 39 g carbohydrate) on postprandial plasma triacylglycerol (TG) concentrations, endothelial function (flow mediated dilation (FMD)), plasma nitrite concentrations and NADPH oxidase activity. Test fats were: a commercially available IE spread, a functionally equivalent non-IE spread, spreadable butter (SB), and a high-MUFA oil (rapeseed oil) as control. Melt curve data for the spreadable fats showed similar solid fat content at 37°C (IE; 0.3%, non-IE; 0.4%, SB; 0%). Blood was collected at fasting and regular intervals up to 8 hrs, and FMD was measured at fasting, 4.5 hrs and 7.5 hrs. Results All 4 test fats increased TG levels postprandially, reaching peak concentrations at 6 hrs. There was no significant treatment or treatment x time effects on plasma TAG concentrations (P = 0.684), nor incremental areas under the curves up to 4 and 8 hrs; mean iAUC0–8 h (95% CI) were 5.4 mmol/L.h (4.3, 6.4) for IE spread, 5.7 mmol/L.h (4.3, 6.8) for non-IE spread, 5.5 mmol/L.h (4.0, 7.0) for SB and 5.9 mmol/L.h (4.3,6.8) for rapeseed oil. There were no significant treatment effects on endothelial function, while nitrite concentrations and NADPH oxidase activity reduced postprandially. Mean NAPDH oxidase activity following IE spread, non-IE spread, SB and rapeseed oil at 6 h were 322, 333, 270, and 268 respectively. Conclusions In the first study to investigate the acute effects of commercially relevant IE and non-IE spreads and SB, we report no adverse effect of IE fats on acutely changing cardiometabolic risk factors relative to a high-MUFA reference oil. The similar effects on endothelial function and postprandial lipemia is likely to be due to their similar solid fat content at body temperature. Funding Sources BBSRC.

scholarly journals Alternative Foods in Cardio-Healthy Dietary Models That Improve Postprandial Lipemia and Insulinemia in Obese People

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2225
Author(s):  
Diana Maria Muñoz-Perez ◽  
Clara Helena Gonzalez-Correa ◽  
Elcy Yaned Astudillo-Muñoz ◽  
Gloria Liliana Porras-Hurtado ◽  
Maite Sanchez-Giraldo ◽  
...  
Keyword(s):  
Postprandial Lipemia ◽  
Saturated Fat ◽  
Whole Grains ◽  
Obese People ◽  
Major Health ◽  
Beneficial Effects ◽  
Postprandial State ◽  
Randomized Controlled ◽  
High Consumption ◽  
Healthy Diets

Obesity is one of the major health problems worldwide. Following healthy dietary patterns can be difficult in some countries due to the lack of availability of certain foods; thus, alternative foods are needed. Our aim was to evaluate the effect of a dietary pattern consisting of fruit, avocado, whole grains, and trout (FAWGT) on postprandial insulinemia and lipemia in obese Colombian subjects. A randomized controlled crossover study was conducted, in which 44 subjects with BMI ≥ 30 kg/m2 followed either a FAWGT diet or a diet high in saturated fat and rich in processed carbohydrates. Levels of lipids and carbohydrates were measured during the postprandial state. The FAWGT diet reduced fasting insulin, VLDL, and HOMA-IR after 8 weeks (p < 0.05), while there was a lower postprandial increase in TG, VLDL, and insulin levels after both acute and chronic intake of FAWGT diet (p < 0.05). The intake of FAWGT-diet was characterized by high consumption of foods rich in fiber, MUFAs, and vitamins C and E (p < 0.05). The consumption of a diet composed of fruit, avocado, whole grains, and trout has emerged as a valid alternative to the foods included in other heart-healthy diets since it improves postprandial lipemia and insulinemia in obese people and has similar beneficial effects to these healthy models.

The safety and efficacy of denosumab versus zoledronic acid in the treatment of pediatric osteoporosis: a randomized controlled pilot trial

2019 ◽  
Author(s):  
Marie-Eve Robinson ◽  
Jinhui Ma ◽  
Nasrin Khan ◽  
Karine Khatchadourian ◽  
Marika Page ◽  
...  
Keyword(s):  
Zoledronic Acid ◽  
Pilot Trial ◽  
Safety And Efficacy ◽  
Randomized Controlled
Sign in / Sign up

Export Citation Format

Share Document