Dietary salicylates in herbs and spices

2019 ◽  
Vol 10 (11) ◽  
pp. 7037-7041 ◽  
Author(s):  
Danuta Gajewska ◽  
Paulina Katarzyna Kęszycka ◽  
Michał Szkop
Keyword(s):  
Fluorescence Detection ◽  
Hplc Method ◽  
Rp Hplc ◽  
Culinary Herbs ◽  
Herbs And Spices

The aim of this study was to determine dietary salicylate content in selected culinary herbs and spices, using the RP-HPLC method with fluorescence detection.

Development of validated RP HPLC method with fluorescence detection for simultaneous quantification of sacubitril and valsartan from rat plasma

2018 ◽  
Vol 41 (5) ◽  
pp. 246-252 ◽  
Author(s):  
Mahesh Attimarad ◽  
Sree Harsha Nagaraja ◽  
Anroop Balachandran Nair ◽  
Bandar Essa Aldhubaib ◽  
Venugopala Narayanaswamy Katharigatta
Keyword(s):  
Fluorescence Detection ◽  
Rat Plasma ◽  
Hplc Method ◽  
Simultaneous Quantification ◽  
Rp Hplc

RP-HPLC method with fluorescence detection for amino acids D /L ratio determination in fossil bones as a marker of DNA preservation

2010 ◽  
Vol 33 (16) ◽  
pp. 2411-2416 ◽  
Author(s):  
Piera Iuliani ◽  
Lucia Di Federico ◽  
Gabriella Fontecchio ◽  
Giuseppe Carlucci
Keyword(s):  
Amino Acids ◽  
Fluorescence Detection ◽  
Hplc Method ◽  
Dna Preservation ◽  
Rp Hplc ◽  
Fossil Bones ◽  
Ratio Determination

Tissue distribution of 10-methoxycamptothecin and its metabolite 10-hydroxycamptothecin in rats by a RP-HPLC method with fluorescence detection/UV detection

2015 ◽  
Vol 7 (18) ◽  
pp. 7690-7696 ◽  
Author(s):  
Changmin Shao ◽  
Jian Zheng ◽  
Bo Fan ◽  
Shaman Luo ◽  
Jixiang Lin ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Tissue Distribution ◽  
Fluorescence Detection ◽  
Broad Spectrum ◽  
Hplc Method ◽  
Uv Detection ◽  
Camptotheca Acuminata ◽  
Rp Hplc ◽  
Derivatives Of

Both 10-methoxycamptothecin (MCPT) and 10-hydroxycamptothecin (HCPT) are natural derivatives of camptothecin (CPT) isolated from Camptotheca acuminata, possessing broad-spectrum antitumor activity.

scholarly journals Excretion study of 10-Methoxycamptothecin and its metabolite 10-Hydroxycamptothecin in rats by RP-HPLC method with fluorescence detection

2017 ◽  
Vol 29 (4) ◽  
pp. 453-458 ◽  
Author(s):  
Changmin Shao ◽  
Jian Zheng ◽  
Junjie Chi ◽  
Lijia Jing ◽  
Xiufeng Yan ◽  
...  
Keyword(s):  
Fluorescence Detection ◽  
Hplc Method ◽  
Rp Hplc ◽  
Excretion Study

scholarly journals Analytical quality by design approach for the control of potentially counterfeit chloroquine with some NSAIDS using HPLC with fluorescence detection in pharmaceutical preparation and breast milk

2020 ◽  
Author(s):  
Said A. Hassan ◽  
Noha Ibrahim ◽  
Eman S. Elzanfaly ◽  
Ahmed E. El Gendy
Keyword(s):  
Breast Milk ◽  
Fluorescence Detection ◽  
Flow Rate ◽  
Hplc Method ◽  
Dihydrogen Phosphate ◽  
Second Phase ◽  
Fluorescence Detector ◽  
Method Performance ◽  
Rp Hplc ◽  
Run Time

AbstractChloroquine phosphate (CQ) the antimalarial drug and suggested to treat the pandemic disease coronavirus (COVID-19) is often adulterated with some of the non-steroidal anti-inflammatory drugs (NSAIDs) such as paracetamol, aspirin (ASP), or both. The purpose of this study is to detect such counterfeited drugs, using a reversed phase high pressure liquid chromatography (RP-HPLC) method with fluorescence detection. Analysis was divided into three phases. In the first phase, a Plackett-Burman design (PBD) was used to screen five independent factors, namely, buffer pH, buffer concentration (mM), acetonitrile content (%), flow rate (mL/min) and triethylamine (TEA) content in the buffer preparation (%). The selected dependent variables were (resolution, symmetry of peaks and run time). The objective of the second phase was to optimize the method performance using Box-Behnken design (BBD) and desirability function for multiple response optimization to obtain the best chromatographic performance with the shortest run time. Optimal chromatographic separation was achieved on a YMC-pack pro C18 ODS-A column (15 cm × 4.6 mm, 5 µm) at room temperature The optimum mobile phase consisted of acetonitrile and 5 mM sodium dihydrogen phosphate buffer containing 0.5% triethyamine (30:70, v/v) with the pH adjusted to 3.5 using an orthophosphoric acid solution. The flow rate was maintained at 1 mL/min, and the detection was performed with a fluorescence detector fixed at 380 nm (λemission) after excitation at 335 nm (λexcitation). The third phase was method validation according to ICH guidelines, providing to be specific, precise, accurate, and robust. The method is linear over a range of 0.4–8 µg/mL for chloroquine and ASP, while for paracetamol it is linear over 16–48 µg/mL. The developed RP-HPLC method was used for quantitation of the three drugs in chloroquine dosage form samples. The method shows a great tendency in the classification between the genuine chloroquine and the adulterated ones in pharmaceutical preparations and breast milk.

RP-HPLC method development for simultaneous determination of the drugs Ramipril and Amlodipine

2012 ◽  
Vol 2 (2) ◽  
pp. 364-367 ◽  
Author(s):  
Saida Naik Dheeravath ◽  
◽  
Kasani Ramadevi ◽  
Zilla Saraswathi ◽  
Dheeravath Maniklal ◽  
...  
Keyword(s):  
Simultaneous Determination ◽  
Method Development ◽  
Hplc Method ◽  
Rp Hplc ◽  
Hplc Method Development
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