Characterization and comparison of milk fat globule membrane N-glycoproteomes from human and bovine colostrum and mature milk

2019 ◽  
Vol 10 (8) ◽  
pp. 5046-5058 ◽  
Author(s):  
Xueyan Cao ◽  
Yan Zheng ◽  
Shangyi Wu ◽  
Ning Yang ◽  
Junrui Wu ◽  
...  
Keyword(s):  
Milk Fat ◽  
Bovine Colostrum ◽  
Biological Functions ◽  
Mature Milk ◽  
Milk Fat Globule Membrane ◽  
Milk Fat Globule ◽  
Fat Globule

Comparison of MFGM N-glycoproteomes among human and bovine colostrum and mature milk reveals diverse compositions and biological functions among them.

Quantitative proteomic analysis of milk fat globule membrane (MFGM) proteins in human and bovine colostrum and mature milk samples through iTRAQ labeling

2016 ◽  
Vol 7 (5) ◽  
pp. 2438-2450 ◽  
Author(s):  
Mei Yang ◽  
Min Cong ◽  
Xiuming Peng ◽  
Junrui Wu ◽  
Rina Wu ◽  
...  
Keyword(s):  
Proteomic Analysis ◽  
Milk Fat ◽  
Bovine Colostrum ◽  
Mature Milk ◽  
Milk Fat Globule Membrane ◽  
Quantitative Proteomic Analysis ◽  
Itraq Labeling ◽  
Milk Samples ◽  
Milk Fat Globule ◽  
Fat Globule

Milk fat globule membrane (MFGM) proteins have many functions.

Comparative proteomics of milk fat globule membrane in goat colostrum and mature milk

2016 ◽  
Vol 209 ◽  
pp. 10-16 ◽  
Author(s):  
Jing Lu ◽  
Lu Liu ◽  
Xiaoyang Pang ◽  
Shuwen Zhang ◽  
Zhenhu Jia ◽  
...  
Keyword(s):  
Milk Fat ◽  
Comparative Proteomics ◽  
Mature Milk ◽  
Milk Fat Globule Membrane ◽  
Milk Fat Globule ◽  
Fat Globule

scholarly journals A High-Throughput Comparative Proteomics of Milk Fat Globule Membrane Reveals Breed and Lactation Stages Specific Variation in Protein Abundance and Functional Differences Between Milk of Saanen Dairy Goat and Holstein Bovine

2021 ◽  
Vol 8 ◽  
Author(s):  
Wei Jia ◽  
Rong Zhang ◽  
Zhenbao Zhu ◽  
Lin Shi
Keyword(s):  
Lipid Metabolism ◽  
Milk Fat ◽  
Goat Milk ◽  
Differentially Expressed ◽  
Dairy Goat ◽  
Differentially Expressed Proteins ◽  
Mature Milk ◽  
Milk Fat Globule Membrane ◽  
Milk Fat Globule ◽  
Fat Globule

Large variations in the bioactivities and composition of milk fat globule membrane (MFGM) proteins were observed between Saanen dairy goat and Holstein bovine at various lactation periods. In the present study, 331, 250, 182, and 248 MFGM proteins were characterized in colostrum and mature milk for the two species by Q-Orbitrap HRMS-based proteomics techniques. KEGG pathway analyses displayed that differentially expressed proteins in colostrum involved in galactose metabolism and an adipogenesis pathway, and the differentially expressed proteins in mature milk associated with lipid metabolism and a PPAR signaling pathway. These results indicated that the types and functions of MFGM proteins in goat and bovine milk were different, and goat milk had a better function of fatty acid metabolism and glucose homeostasis, which can enhance our understanding of MFGM proteins in these two species across different lactation periods, and they provide significant information for the study of lipid metabolism and glycometabolism of goat milk.

scholarly journals Characterization of the milk fat globule membrane proteome in colostrum and mature milk of Xinong Saanen goats

2020 ◽  
Vol 103 (4) ◽  
pp. 3017-3024 ◽  
Author(s):  
Yuxue Sun ◽  
Cuina Wang ◽  
Xiaomeng Sun ◽  
Shilong Jiang ◽  
Mingruo Guo
Keyword(s):  
Milk Fat ◽  
Membrane Proteome ◽  
Mature Milk ◽  
Milk Fat Globule Membrane ◽  
Milk Fat Globule ◽  
Fat Globule

Quantitative proteomic analysis of milk fat globule membrane (MFGM) proteins from donkey colostrum and mature milk

2019 ◽  
Vol 10 (7) ◽  
pp. 4256-4268 ◽  
Author(s):  
Weixuan Li ◽  
Mohan Li ◽  
Xueyan Cao ◽  
Mei Yang ◽  
Hongjiao Han ◽  
...  
Keyword(s):  
Proteomic Analysis ◽  
Milk Fat ◽  
Nutritional Quality ◽  
Mature Milk ◽  
Milk Fat Globule Membrane ◽  
Quantitative Proteomic Analysis ◽  
Milk Fat Globule ◽  
Fat Globule ◽  
Quality Of Milk

The composition and functions of milk fat globule membrane (MFGM) proteins are important indicators of the nutritional quality of milk.

Quantitative N-glycoproteomics of milk fat globule membrane in human colostrum and mature milk reveals changes in protein glycosylation during lactation

2018 ◽  
Vol 9 (2) ◽  
pp. 1163-1172 ◽  
Author(s):  
Xueyan Cao ◽  
Shimo Kang ◽  
Mei Yang ◽  
Weixuan Li ◽  
Shangyi Wu ◽  
...  
Keyword(s):  
Milk Fat ◽  
Site Occupancy ◽  
Glycosylation Site ◽  
Protein Glycosylation ◽  
Mature Milk ◽  
Milk Fat Globule Membrane ◽  
Human Colostrum ◽  
Milk Fat Globule ◽  
Fat Globule ◽  
Glycosylation Site Occupancy

The present study profiled the N-glycoproteome and quantified the changes of N-glycosylation site occupancy of MFGM proteins during lactation.

scholarly journals Quantitative Label-Free Proteomic Analysis of Milk Fat Globule Membrane in Donkey and Human Milk

2021 ◽  
Vol 8 ◽  
Author(s):  
Xinhao Zhang ◽  
Bo Jiang ◽  
Chuanliang Ji ◽  
Haijing Li ◽  
Li Yang ◽  
...  
Keyword(s):  
Human Milk ◽  
Milk Fat ◽  
Peroxisome Proliferator ◽  
Label Free ◽  
Biological Functions ◽  
Galactose Metabolism ◽  
Peroxisome Proliferator Activated Receptor ◽  
Milk Fat Globule Membrane ◽  
Milk Fat Globule ◽  
Fat Globule

Previous studies have found donkey milk (DM) has the similar compositions with human milk (HM) and could be used as a potential hypoallergenic replacement diet for babies suffering from cow's milk allergy. Milk fat globule membrane (MFGM) proteins are involved in many biological functions, behaving as important indicators of the nutritional quality of milk. In this study, we used label-free proteomics to quantify the differentially expressed MFGM proteins (DEP) between DM (in 4–5 months of lactation) and HM (in 6–8 months of lactation). In total, 293 DEP were found in these two groups. Gene Ontology (GO) enrichment analysis revealed that the majority of DEP participated in regulation of immune system process, membrane invagination and lymphocyte activation. Several significant Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways were determined for the DEP, such as lysosome, galactose metabolism and peroxisome proliferator-activated receptor (PPAR) signaling pathway. Our study may provide valuable information in the composition of MFGM proteins in DM and HM, and expand our knowledge of different biological functions between DM and HM.

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