Quantitative N-glycoproteomics of milk fat globule membrane in human colostrum and mature milk reveals changes in protein glycosylation during lactation

2018 ◽  
Vol 9 (2) ◽  
pp. 1163-1172 ◽  
Author(s):  
Xueyan Cao ◽  
Shimo Kang ◽  
Mei Yang ◽  
Weixuan Li ◽  
Shangyi Wu ◽  
...  
Keyword(s):  
Milk Fat ◽  
Site Occupancy ◽  
Glycosylation Site ◽  
Protein Glycosylation ◽  
Mature Milk ◽  
Milk Fat Globule Membrane ◽  
Human Colostrum ◽  
Milk Fat Globule ◽  
Fat Globule ◽  
Glycosylation Site Occupancy

The present study profiled the N-glycoproteome and quantified the changes of N-glycosylation site occupancy of MFGM proteins during lactation.

Quantitative proteomic analysis of milk fat globule membrane (MFGM) proteins in human and bovine colostrum and mature milk samples through iTRAQ labeling

2016 ◽  
Vol 7 (5) ◽  
pp. 2438-2450 ◽  
Author(s):  
Mei Yang ◽  
Min Cong ◽  
Xiuming Peng ◽  
Junrui Wu ◽  
Rina Wu ◽  
...  
Keyword(s):  
Proteomic Analysis ◽  
Milk Fat ◽  
Bovine Colostrum ◽  
Mature Milk ◽  
Milk Fat Globule Membrane ◽  
Quantitative Proteomic Analysis ◽  
Itraq Labeling ◽  
Milk Samples ◽  
Milk Fat Globule ◽  
Fat Globule

Milk fat globule membrane (MFGM) proteins have many functions.

Comparative proteomics of milk fat globule membrane in goat colostrum and mature milk

2016 ◽  
Vol 209 ◽  
pp. 10-16 ◽  
Author(s):  
Jing Lu ◽  
Lu Liu ◽  
Xiaoyang Pang ◽  
Shuwen Zhang ◽  
Zhenhu Jia ◽  
...  
Keyword(s):  
Milk Fat ◽  
Comparative Proteomics ◽  
Mature Milk ◽  
Milk Fat Globule Membrane ◽  
Milk Fat Globule ◽  
Fat Globule

scholarly journals A High-Throughput Comparative Proteomics of Milk Fat Globule Membrane Reveals Breed and Lactation Stages Specific Variation in Protein Abundance and Functional Differences Between Milk of Saanen Dairy Goat and Holstein Bovine

2021 ◽  
Vol 8 ◽  
Author(s):  
Wei Jia ◽  
Rong Zhang ◽  
Zhenbao Zhu ◽  
Lin Shi
Keyword(s):  
Lipid Metabolism ◽  
Milk Fat ◽  
Goat Milk ◽  
Differentially Expressed ◽  
Dairy Goat ◽  
Differentially Expressed Proteins ◽  
Mature Milk ◽  
Milk Fat Globule Membrane ◽  
Milk Fat Globule ◽  
Fat Globule

Large variations in the bioactivities and composition of milk fat globule membrane (MFGM) proteins were observed between Saanen dairy goat and Holstein bovine at various lactation periods. In the present study, 331, 250, 182, and 248 MFGM proteins were characterized in colostrum and mature milk for the two species by Q-Orbitrap HRMS-based proteomics techniques. KEGG pathway analyses displayed that differentially expressed proteins in colostrum involved in galactose metabolism and an adipogenesis pathway, and the differentially expressed proteins in mature milk associated with lipid metabolism and a PPAR signaling pathway. These results indicated that the types and functions of MFGM proteins in goat and bovine milk were different, and goat milk had a better function of fatty acid metabolism and glucose homeostasis, which can enhance our understanding of MFGM proteins in these two species across different lactation periods, and they provide significant information for the study of lipid metabolism and glycometabolism of goat milk.

scholarly journals Characterization of the milk fat globule membrane proteome in colostrum and mature milk of Xinong Saanen goats

2020 ◽  
Vol 103 (4) ◽  
pp. 3017-3024 ◽  
Author(s):  
Yuxue Sun ◽  
Cuina Wang ◽  
Xiaomeng Sun ◽  
Shilong Jiang ◽  
Mingruo Guo
Keyword(s):  
Milk Fat ◽  
Membrane Proteome ◽  
Mature Milk ◽  
Milk Fat Globule Membrane ◽  
Milk Fat Globule ◽  
Fat Globule

Quantitative proteomic analysis of milk fat globule membrane (MFGM) proteins from donkey colostrum and mature milk

2019 ◽  
Vol 10 (7) ◽  
pp. 4256-4268 ◽  
Author(s):  
Weixuan Li ◽  
Mohan Li ◽  
Xueyan Cao ◽  
Mei Yang ◽  
Hongjiao Han ◽  
...  
Keyword(s):  
Proteomic Analysis ◽  
Milk Fat ◽  
Nutritional Quality ◽  
Mature Milk ◽  
Milk Fat Globule Membrane ◽  
Quantitative Proteomic Analysis ◽  
Milk Fat Globule ◽  
Fat Globule ◽  
Quality Of Milk

The composition and functions of milk fat globule membrane (MFGM) proteins are important indicators of the nutritional quality of milk.

Characterization and comparison of milk fat globule membrane N-glycoproteomes from human and bovine colostrum and mature milk

2019 ◽  
Vol 10 (8) ◽  
pp. 5046-5058 ◽  
Author(s):  
Xueyan Cao ◽  
Yan Zheng ◽  
Shangyi Wu ◽  
Ning Yang ◽  
Junrui Wu ◽  
...  
Keyword(s):  
Milk Fat ◽  
Bovine Colostrum ◽  
Biological Functions ◽  
Mature Milk ◽  
Milk Fat Globule Membrane ◽  
Milk Fat Globule ◽  
Fat Globule

Comparison of MFGM N-glycoproteomes among human and bovine colostrum and mature milk reveals diverse compositions and biological functions among them.

scholarly journals Milk Fat Globule Membrane Proteome and Micronutrients in the Milk Lipid Fraction: Insights into Milk Bioactive Compounds

Dairy ◽  
2021 ◽  
Vol 2 (2) ◽  
pp. 202-217
Author(s):  
Michele Manoni ◽  
Donata Cattaneo ◽  
Sharon Mazzoleni ◽  
Carlotta Giromini ◽  
Antonella Baldi ◽  
...  
Keyword(s):  
Milk Fat ◽  
Lipid Fraction ◽  
Value Added ◽  
Milk Lipid ◽  
Milk Fat Globule Membrane ◽  
Fat Globules ◽  
Milk Fat Globules ◽  
Milk Fat Globule ◽  
Fat Globule ◽  
Value Added Products

Milk lipids are composed of milk fat globules (MFGs) surrounded by the milk fat globule membrane (MFGM). MFGM protects MFGs from coalescence and enzymatic degradation. The milk lipid fraction is a “natural solvent” for macronutrients such as phospholipids, proteins and cholesterol, and micronutrients such as minerals and vitamins. The research focused largely on the polar lipids of MFGM, given their wide bioactive properties. In this review we discussed (i) the composition of MFGM proteome and its variations among species and phases of lactation and (ii) the micronutrient content of human and cow’s milk lipid fraction. The major MFGM proteins are shared among species, but the molecular function and protein expression of MFGM proteins vary among species and phases of lactation. The main minerals in the milk lipid fraction are iron, zinc, copper and calcium, whereas the major vitamins are vitamin A, β-carotene, riboflavin and α-tocopherol. The update and the combination of this knowledge could lead to the exploitation of the MFGM proteome and the milk lipid fraction at nutritional, biological or technological levels. An example is the design of innovative and value-added products, such as MFGM-supplemented infant formulas.

PROTEOME OF MILK FAT GLOBULE MEMBRANE AND MAMMARY GLAND TISSUE IN GOAT FED DIFFERENT LIPID SUPPLEMENTATION

2021 ◽  
pp. 106378
Author(s):  
Iolly Tábata Oliveira Marques ◽  
Fábio Roger Vasconcelos ◽  
Juliana Paula Martins Alves ◽  
Assis Rubens Montenegro ◽  
César Carneiro Linhares Fernandes ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Milk Fat ◽  
Milk Fat Globule Membrane ◽  
Mammary Gland Tissue ◽  
Gland Tissue ◽  
Milk Fat Globule ◽  
Lipid Supplementation ◽  
Fat Globule
Sign in / Sign up

Export Citation Format

Share Document