In vivo evaluation of the toxic and genotoxic effects of exposure to cobalt nanoparticles using Drosophila melanogaster

2020 ◽  
Vol 7 (2) ◽  
pp. 610-622 ◽  
Author(s):  
Mohamed Alaraby ◽  
Esref Demir ◽  
Josefa Domenech ◽  
Antonia Velázquez ◽  
Alba Hernández ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Environmental Impact ◽  
Cobalt Nanoparticles ◽  
Potential Toxicity ◽  
Genotoxic Effects ◽  
In Vivo Evaluation ◽  
Safety Issues

Nanomaterials in general and cobalt nanoparticles (CoNPs) in particular are of great interest not only because of their multiple applications and environmental impact, but also for their potential toxicity and safety issues.

scholarly journals In Vivo Evaluation of the Genotoxic Effects of Poly (Butylene adipate-co-terephthalate)/Polypyrrole with Nanohydroxyapatite Scaffolds for Bone Regeneration

Materials ◽  
2019 ◽  
Vol 12 (8) ◽  
pp. 1330 ◽  
Author(s):  
Conceição de Maria Vaz Elias ◽  
Antônio Luiz Martins Maia Filho ◽  
Laryssa Roque da Silva ◽  
Fabrício Pires de Moura do Amaral ◽  
Thomas J. Webster ◽  
...  
Keyword(s):  
Micronucleus Test ◽  
Infusion Pump ◽  
Tail Length ◽  
Positive Control ◽  
Negative Control ◽  
Electrospinning Process ◽  
Genotoxic Effects ◽  
In Vivo Evaluation ◽  
In Vivo Assays

Here, butylene adipate-co-terephthalate/polypyrrole with nanohydroxyapatite (PBAT/PPy/nHAp) scaffolds were fabricated and characterized. The electrospinning process was carried out using 12 kV, a needle of 23 G, an infusion pump set at 0.3 mL/h, and 10 cm of distance. Afterwards, nHAp was directly electrodeposited onto PBAT/PPy scaffolds using a classical three-electrode apparatus. For in vivo assays (comet assay, acute and chronic micronucleus), 60 male albino Wistar rats with 4 groups were used in each test (n = 5): PBAT/PPy; PBAT/PPy/nHAp; positive control (cyclophosphamide); and the negative control (distilled water). Peripheral blood samples were collected from the animals to perform the comet test after 4 h (for damage) and 24 h (for repair). In the comet test, it was shown that the scaffolds did not induce damage to the % DNA tail and neither for tail length. After the end of 48 h (for acute micronucleus) and 72 h (for chronic micronucleus), bone marrow was collected from each rat to perform the micronucleus test. All of the produced scaffolds did not present genotoxic effects, providing strong evidence for the biological application of PBAT/PPy/nHAp scaffolds.

Drosophila melanogaster as an in vivo model to study the potential toxicity of cerium oxide nanoparticles

2019 ◽  
Vol 490 ◽  
pp. 70-80 ◽  
Author(s):  
Vignesh Sundararajan ◽  
Pallavi Dan ◽  
Ajay Kumar ◽  
G. Devanand Venkatasubbu ◽  
Sahoko Ichihara ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Cerium Oxide ◽  
Cerium Oxide Nanoparticles ◽  
In Vivo Model ◽  
Oxide Nanoparticles ◽  
Potential Toxicity

In vivo Evaluation of the Genotoxic Effects of Clomiphene Citrate on Rat Reticulocytes: A Micronucleus Genotoxicity

2006 ◽  
Vol 61 (4) ◽  
pp. 228-231 ◽  
Author(s):  
Bulent Duran ◽  
Ismail Ozdemir ◽  
Yeltekin Demirel ◽  
Ozturk Ozdemir ◽  
Ali Cetin ◽  
...  
Keyword(s):  
Clomiphene Citrate ◽  
Genotoxic Effects ◽  
In Vivo Evaluation ◽  
Rat Reticulocytes

In vivo genotoxic effects of four different nano-sizes forms of silica nanoparticles in Drosophila melanogaster

2015 ◽  
Vol 283 ◽  
pp. 260-266 ◽  
Author(s):  
Eşref Demir ◽  
Sezgin Aksakal ◽  
Fatma Turna ◽  
Bülent Kaya ◽  
Ricard Marcos
Keyword(s):  
Drosophila Melanogaster ◽  
Silica Nanoparticles ◽  
Genotoxic Effects

In Vitro and In Vivo Evaluation of Potential Toxicity of Industrial Particles

1980 ◽  
pp. 431-443
Author(s):  
Catherine Aranyi ◽  
Jeannie Bradof ◽  
Donald E. Gardner ◽  
Joellen Lewtas Huisingh
Keyword(s):  
Potential Toxicity ◽  
In Vivo Evaluation

scholarly journals Genotoxicity of Copper and Nickel Nanoparticles in Somatic Cells of Drosophila melanogaster

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Erico R. Carmona ◽  
Alba García-Rodríguez ◽  
Ricard Marcos
Keyword(s):  
Drosophila Melanogaster ◽  
Laser Doppler Velocimetry ◽  
Antimicrobial Agents ◽  
Nickel Nanoparticles ◽  
Somatic Cells ◽  
Industrial Applications ◽  
Electronic Microscopy ◽  
Genotoxic Effects

Copper and nickel nanoparticles (Cu-NPs and Ni-NPs, respectively) are used in a variety of industrial applications, such as semiconductors, catalysts, sensors, and antimicrobial agents. Although studies on its potential genotoxicity already exist, few of them report in vivo data. In the present study we have used the wing-spot assay in Drosophila melanogaster to determine the genotoxic activity of Cu-NPs and Ni-NPs, and these data have been compared with those obtained with their microparticle forms (MPs). Additionally, a complete physical characterization of NPs using transmission electronic microscopy (TEM), dynamic light scattering (DLS), and laser Doppler velocimetry (LDV) techniques was also performed. Results obtained with Cu-NPs and Cu-MPs indicate that both failed to induce an increase in the frequency of mutant spots formation in the wings of the adults, suggesting a lack of genotoxicity in somatic cells of D. melanogaster. However, when Ni-NPs and Ni-MPs were evaluated, a significant increase of small single spots and total mutant spots was observed only for Ni-NPs (P<0.05) at the highest dose assessed. Thus, the genotoxicity of Ni-NPs seem to be related to their nanoscale size, because no genotoxic effects have been reported with their microparticles and ions. This study is the first assessing the in vivo genotoxic potential of Cu-NPs and Ni-NPs in the Drosophila model.

scholarly journals In vivo evaluation of the toxicity, genotoxicity, histopathological, and anti-inflammatory effects of the purified bioglycerol byproduct in biodiesel industry

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Wesam Taha Basal ◽  
Aliaa Mahmoud Issa ◽  
Shehab Eldin Sayed Mohammed ◽  
Saher Abd-Elhafeez Mazen
Keyword(s):  
Animal Models ◽  
Fossil Fuel ◽  
Good Alternative ◽  
Genotoxic Effects ◽  
In Vivo Evaluation ◽  
Food Industries ◽  
Skin Contact ◽  
Anti Inflammatory ◽  
Biodiesel Industry

Abstract Background Biodiesel has gained an increased popularity as a good alternative for fossil fuel because of its unusual qualities as a biodegradable, nontoxic, and renewable diesel fuel. Hence, the economic utilization of the accumulated bioglycerol byproduct became critically important for the sustainability of biodiesel industry. The purified bioglycerol might be used as a valuable industrial stock in cosmetic, medical, and food industries. However, if the purified product is going to be used in food, drug, or any industry that involves its ingestion or skin contact by human or animals, the product should be thoroughly tested on animal models. Results The present study investigated the acute toxicity, anti-inflammatory, histopathological, and genotoxic effects of zeolite-purified biogylcerol on different animal models. All the previous tests proved the ability of the purification process to improve the qualities of the crude bioglycerol to a degree comparable to the pharmaceutical grade glycerol. Conclusion In other words, it could be concluded that zeolite-purified bioglycerol can be used in different industries that involves products consumed by human or animals.

scholarly journals In vivo evaluation of the toxic activity and genotoxicity of the Hymenaea courbaril L.’s resin in Drosophila melanogaster

2021 ◽  
Author(s):  
Jorge Anaya-Gil ◽  
Patricia Ramos-Morales ◽  
Adriana Muñoz-Hernandez ◽  
Adriana Bermúdez ◽  
Harold Gomez-Estrada
Keyword(s):  
Drosophila Melanogaster ◽  
In Vivo Evaluation ◽  
Toxic Activity ◽  
Hymenaea Courbaril

scholarly journals In Vivo Evaluation of the Genotoxic Effects of Gonadotropins on Rat Reticulocytes

2011 ◽  
Vol 72 (2) ◽  
pp. 60-70 ◽  
Author(s):  
Bulent Duran ◽  
Onder Koc ◽  
Safak Ozdemirci ◽  
Ata Topcuoglu ◽  
Ozturk Ozdemir
Keyword(s):  
Genotoxic Effects ◽  
In Vivo Evaluation ◽  
Rat Reticulocytes

scholarly journals In vivo evaluation of the genotoxic effects of Hyrax auxiliary orthodontic appliances containing silver-soldered joints

2015 ◽  
Vol 791 ◽  
pp. 25-29 ◽  
Author(s):  
Tatiana Siqueira Gonçalves ◽  
Luciane Macedo de Menezes ◽  
Cristiano Trindade ◽  
Philip Thomas ◽  
Michael Fenechc ◽  
...  
Keyword(s):  
Orthodontic Appliances ◽  
Genotoxic Effects ◽  
In Vivo Evaluation
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