A comparative study on the nickel binding ability of peptides containing separate cysteinyl residues

2019 ◽  
Vol 48 (44) ◽  
pp. 16800-16811
Author(s):  
Györgyi Szunyog ◽  
Aliz Laskai ◽  
Dóra Szűcs ◽  
Imre Sóvágó ◽  
Katalin Várnagy
Keyword(s):  
Comparative Study ◽  
Metal Binding ◽  
Binding Affinities ◽  
Binding Modes ◽  
Binding Ability ◽  
Nickel Binding ◽  
Major Species

The different metal binding affinities of two cysteine containing oligopeptides are related to the different binding modes of the major species.

scholarly journals Deferoxamine B: A Natural, Excellent and Versatile Metal Chelator

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3255
Author(s):  
Denise Bellotti ◽  
Maurizio Remelli
Keyword(s):  
Metal Ions ◽  
Metal Binding ◽  
Chelation Therapy ◽  
Iron Chelation ◽  
Binding Ability ◽  
Complex Formation Equilibria ◽  
Metal Chelator ◽  
The Past ◽  
Formation Equilibria ◽  
Terminal Amino

Deferoxamine B is an outstanding molecule which has been widely studied in the past decade for its ability to bind iron and many other metal ions. The versatility of this metal chelator makes it suitable for a number of medicinal and analytical applications, from the well-known iron chelation therapy to the most recent use in sensor devices. The three bidentate hydroxamic functional groups of deferoxamine B are the centerpiece of its metal binding ability, which allows the formation of stable complexes with many transition, lanthanoid and actinoid metal ions. In addition to the ferric ion, in fact, more than 20 different metal complexes of deferoxamine b have been characterized in terms of their chemical speciation in solution. In addition, the availability of a terminal amino group, most often not involved in complexation, opens the way to deferoxamine B modification and functionalization. This review aims to collect and summarize the available data concerning the complex-formation equilibria in solutions of deferoxamine B with different metal ions. A general overview of the progress of its applications over the past decade is also discussed, including the treatment of iron overload-associated diseases, its clinical use against cancer and neurodegenerative disorders and its role as a diagnostic tool.

Specification of the bonding cavities available in metal-binding sites: a comparative study of a series of quadridentate macrocyclic ligands

1984 ◽  
Vol 106 (6) ◽  
pp. 1641-1645 ◽  
Author(s):  
Kim Henrick ◽  
Leonard F. Lindoy ◽  
Mary McPartlin ◽  
Peter A. Tasker ◽  
Michael P. Wood
Keyword(s):  
Comparative Study ◽  
Metal Binding ◽  
Binding Sites ◽  
Macrocyclic Ligands ◽  
Metal Binding Sites

scholarly journals Multinuclear metal-binding ability of a carotene

2015 ◽  
Vol 6 (1) ◽  
Author(s):  
Shinnosuke Horiuchi ◽  
Yuki Tachibana ◽  
Mitsuki Yamashita ◽  
Koji Yamamoto ◽  
Kohei Masai ◽  
...  
Keyword(s):  
Metal Binding ◽  
Binding Ability ◽  
Metal Binding Ability

The effect of non-coordinating side chains on the metal binding affinities of peptides of histidine

Polyhedron ◽  
2013 ◽  
Vol 62 ◽  
pp. 7-17 ◽  
Author(s):  
Ildikó Turi ◽  
Daniele Sanna ◽  
Eugenio Garribba ◽  
Giuseppe Pappalardo ◽  
Imre Sóvágó
Keyword(s):  
Metal Binding ◽  
Side Chains ◽  
Binding Affinities

Metal binding ability of microbial natural metal chelators and potential applications

2020 ◽  
Vol 37 (9) ◽  
pp. 1262-1283 ◽  
Author(s):  
Marika Hofmann ◽  
Gerardo Retamal-Morales ◽  
Dirk Tischler
Keyword(s):  
Metal Binding ◽  
Metal Chelators ◽  
Binding Ability ◽  
Potential Applications ◽  
Metal Binding Ability

Metallophores can chelate many different metal and metalloid ions next to iron, make them valuable for many applications.

Unravelling the versatile metal binding modes of adenine: Looking at the molecular recognition patterns of deaza- and aza-adenines in mixed ligand metal complexes

2013 ◽  
Vol 257 (19-20) ◽  
pp. 2814-2838 ◽  
Author(s):  
Alicia Domínguez-Martín ◽  
María del Pilar Brandi-Blanco ◽  
Antonio Matilla-Hernández ◽  
Hanan El Bakkali ◽  
Valeria Marina Nurchi ◽  
...  
Keyword(s):  
Molecular Recognition ◽  
Metal Complexes ◽  
Metal Binding ◽  
Mixed Ligand ◽  
Binding Modes
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