scholarly journals Deferoxamine B: A Natural, Excellent and Versatile Metal Chelator

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3255
Author(s):  
Denise Bellotti ◽  
Maurizio Remelli
Keyword(s):  
Metal Ions ◽  
Metal Binding ◽  
Chelation Therapy ◽  
Iron Chelation ◽  
Binding Ability ◽  
Complex Formation Equilibria ◽  
Metal Chelator ◽  
The Past ◽  
Formation Equilibria ◽  
Terminal Amino

Deferoxamine B is an outstanding molecule which has been widely studied in the past decade for its ability to bind iron and many other metal ions. The versatility of this metal chelator makes it suitable for a number of medicinal and analytical applications, from the well-known iron chelation therapy to the most recent use in sensor devices. The three bidentate hydroxamic functional groups of deferoxamine B are the centerpiece of its metal binding ability, which allows the formation of stable complexes with many transition, lanthanoid and actinoid metal ions. In addition to the ferric ion, in fact, more than 20 different metal complexes of deferoxamine b have been characterized in terms of their chemical speciation in solution. In addition, the availability of a terminal amino group, most often not involved in complexation, opens the way to deferoxamine B modification and functionalization. This review aims to collect and summarize the available data concerning the complex-formation equilibria in solutions of deferoxamine B with different metal ions. A general overview of the progress of its applications over the past decade is also discussed, including the treatment of iron overload-associated diseases, its clinical use against cancer and neurodegenerative disorders and its role as a diagnostic tool.

Aminobisphosphonates based on cyclohexane backbone as coordinating agents for metal ions. Thermodynamic, spectroscopic and biological studies

2018 ◽  
Vol 42 (10) ◽  
pp. 7723-7736 ◽  
Author(s):  
J. Gałęzowska ◽  
H. Czapor-Irzabek ◽  
E. Chmielewska ◽  
P. Kafarski ◽  
T. Janek
Keyword(s):  
Complex Formation ◽  
Metal Ions ◽  
Complex Formation Equilibria ◽  
Biological Studies ◽  
Speciation Study ◽  
Calcium Magnesium ◽  
Formation Equilibria

Complex formation equilibria of calcium, magnesium, copper and nickel with amino-bisphosphonic ligands are described, together with a speciation study along with calorimetric outcome and cytotoxicity characteristics.

Phosphinic and Phosphonic Acids I: Protonation and Complex Formation Equilibria of Some Substituted Ethane-1,1,2-tris-(P-methyl-phosphinie Acids)

1990 ◽  
Vol 45 (3) ◽  
pp. 323-328 ◽  
Author(s):  
F. Gaizer ◽  
G. Hägele ◽  
S. Goudetsidis ◽  
H. Papadopoulos
Keyword(s):  
Complex Formation ◽  
Metal Ions ◽  
Protonation Constants ◽  
Phosphonic Acids ◽  
Complex Formation Equilibria ◽  
Phosphinic Acids ◽  
Formation Equilibria

Protonation constants were determined pH-metrically for 3 selected phosphinic acids of the type CHRP*—CHP*2 (R = phenyl, methyl, t-butyl; P* = CH3P(O)OH). Complex formation equilibria were studied for metal ions Mg(II), Ca(II), Sr(II), Ba(II), Cu(II), Zn(II), Al(III) and Ga(III). Particular strong complex formation was observed for Ga(III).

Update on Thalassemia

1992 ◽  
Vol 13 (2) ◽  
pp. 55-62
Author(s):  
P. J. Giardina ◽  
M. W. Hilgartner
Keyword(s):  
Chelation Therapy ◽  
Developmental Regulation ◽  
Globin Gene ◽  
Iron Chelation ◽  
Iron Chelators ◽  
Genetic Defects ◽  
Iron Chelation Therapy ◽  
Blood Products ◽  
The Past ◽  
Globin Gene Expression

Many advances in the understanding and management of the thalassmia syndromes have been made during the past several years. Our knowledge of normal globin gene function and of the consequences of specific mutations has been advanced by identification of the genetic defects causing thalassemia. Prenatal diagnosis is now possible with molecular biology technology. Standards have been established for transfusion, splenectomy, prevention of postsplenectomy infection, and effective iron chelation therapy. Bone marrow transplantation is now available for those with a compatible familial donor. Research efforts currently are directed toward safer blood products, oral iron chelators, and improved understanding of the developmental regulation of globin gene expression for effective gene transfer.

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