Solution chemistry and phase solubility diagrams of CL-20/MTNP energetic cocrystals

CrystEngComm ◽  
2020 ◽  
Vol 22 (12) ◽  
pp. 2173-2182
Author(s):  
Luyang Tang ◽  
Hongzhen Li ◽  
Yanwei Tan ◽  
Tiansheng Liu ◽  
Zongwei Yang
Keyword(s):  
Organic Solvents ◽  
Solution Chemistry ◽  
Phase Solubility ◽  
Solubility Diagrams ◽  
Solubility Behavior ◽  
Phase Solubility Diagrams

The solubility behavior and solution chemistry of CL-20/MTNP (2,4,6,8,10,12-hexanitro-hexaaza-isowurtzitane/1-methyl-3,4,5-trinitropyrazole) energetic cocrystals in organic solvents were first investigated to offer some important information on thermodynamics.

Phase Solubility Diagrams of Cocrystals Are Explained by Solubility Product and Solution Complexation

2006 ◽  
Vol 6 (2) ◽  
pp. 592-600 ◽  
Author(s):  
Sarah J. Nehm ◽  
Barbara Rodríguez-Spong ◽  
Naír Rodríguez-Hornedo
Keyword(s):  
Solubility Product ◽  
Phase Solubility ◽  
Solubility Diagrams ◽  
Phase Solubility Diagrams

Solubility Behavior and Solution Chemistry of Indomethacin Cocrystals in Organic Solvents

2011 ◽  
Vol 11 (9) ◽  
pp. 3923-3929 ◽  
Author(s):  
Amjad Alhalaweh ◽  
Anders Sokolowski ◽  
Naír Rodríguez-Hornedo ◽  
Sitaram P. Velaga
Keyword(s):  
Organic Solvents ◽  
Solution Chemistry ◽  
Solubility Behavior

scholarly journals Thermodynamic Investigations on the Inclusion Complexation of Piroxicam with Cyclodextrin Derivatives

2005 ◽  
Vol 73 (3) ◽  
pp. 147-161 ◽  
Author(s):  
Charumanee S. ◽  
Weiss-Greiler P. ◽  
Wolschann P. ◽  
Viernstein H. ◽  
Titwan A. ◽  
...  
Keyword(s):  
Ph Value ◽  
Equilibrium Constants ◽  
Inclusion Complexation ◽  
Solubility Diagram ◽  
Phase Solubility ◽  
Cyclodextrin Derivatives ◽  
Ph Values ◽  
Solubility Behavior ◽  
Solubility Method ◽  
Different Temperatures

Thermodynamic studies of piroxicam in aqueous solution complexed with β-cyclodextrin (β-CD), γ-cyclodextrin (γ-CD) and two β-cyclodextrin derivatives, hydroxypropyl-β-cyclodextrin (HP-P-CD) and methyl-β-cyclodextrin (Me-β-CD) were performed at different temperatures and pH values using the phase solubility method. The phase solubility diagrams of β-CD, γ-CD and HP-β-CD is of AL-type behavior, indicating the formation of 1:l complexes. The related stability constants range from β-CD > γ-CD > Me-β-CD > HP-β-CD, respectively. An Ap-type solubility diagram is observed for Me-β-CD, indicating the formation of 1:2 complexes at higher CD concentrations. From the temperature dependence of the equilibrium constants the reaction enthalpies and entropies have been determined. The contributions of the reaction entropies are small and no enthalpy-entropy-compensation is observed, except for γ-CD, where a very small negative reaction entropy could be estimated. Moreover, the influence of the pH value is rather high because the differently charged forms of piroxicam show different solubility behavior in water.

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