Solubility Behavior and Solution Chemistry of Indomethacin Cocrystals in Organic Solvents

2011 ◽  
Vol 11 (9) ◽  
pp. 3923-3929 ◽  
Author(s):  
Amjad Alhalaweh ◽  
Anders Sokolowski ◽  
Naír Rodríguez-Hornedo ◽  
Sitaram P. Velaga
Keyword(s):  
Organic Solvents ◽  
Solution Chemistry ◽  
Solubility Behavior

Solution chemistry and phase solubility diagrams of CL-20/MTNP energetic cocrystals

CrystEngComm ◽  
2020 ◽  
Vol 22 (12) ◽  
pp. 2173-2182
Author(s):  
Luyang Tang ◽  
Hongzhen Li ◽  
Yanwei Tan ◽  
Tiansheng Liu ◽  
Zongwei Yang
Keyword(s):  
Organic Solvents ◽  
Solution Chemistry ◽  
Phase Solubility ◽  
Solubility Diagrams ◽  
Solubility Behavior ◽  
Phase Solubility Diagrams

The solubility behavior and solution chemistry of CL-20/MTNP (2,4,6,8,10,12-hexanitro-hexaaza-isowurtzitane/1-methyl-3,4,5-trinitropyrazole) energetic cocrystals in organic solvents were first investigated to offer some important information on thermodynamics.

Antimony-Doped Tin Oxide Nanocrystals: Synthesis and Solubility Behavior in Organic Solvents

ChemPhysChem ◽  
2009 ◽  
Vol 10 (5) ◽  
pp. 841-846 ◽  
Author(s):  
Rafael O. da Silva ◽  
Tiago G. Conti ◽  
André F. de Moura ◽  
Daniel G. Stroppa ◽  
Luiz C. G. Freitas ◽  
...  
Keyword(s):  
Organic Solvents ◽  
Tin Oxide ◽  
Solubility Behavior

Solubility predictions for crystalline nonelectrolyte solutes dissolved in organic solvents based upon the Abraham general solvation model

2001 ◽  
Vol 79 (10) ◽  
pp. 1466-1476 ◽  
Author(s):  
William E Acree, Jr. ◽  
Michael H Abraham
Keyword(s):  
Hydrogen Bond ◽  
Gas Phase ◽  
Organic Solvents ◽  
Molar Refraction ◽  
Solvation Model ◽  
Absolute Deviation ◽  
Solubility Behavior ◽  
Water Solvent ◽  
Solubility Predictions ◽  
Hydrogen Bond Acidity

The Abraham general solvation model is used to predict the saturation solubility of crystalline nonelectrolyte solutes in organic solvents. The derived equations take the form of log (CS/CW) = c + rR2 + sπ2H + aΣα2H + bΣβ2H + vVx and log (CS/CG) = c + rR2 + sπ2H + aΣα2H + bΣβ2H + l log L(16) where CS and CW refer to the solute solubility in the organic solvent and water, respectively, CG is a gas-phase concentration, R2 is the solute's excess molar refraction, Vx is McGowan volume of the solute, Σα2H and Σβ2H are measures of the solute's hydrogen-bond acidity and hydrogen-bond basicity, π2H denotes the solute's dipolarity and (or) polarizability descriptor, and log L(16) is the solute's gas-phase dimensionless Ostwald partition coefficient into hexadecane at 298 K. The remaining symbols in the above expressions are known equation coefficients, which have been determined previously for a large number of gas–solvent and water–solvent systems. Computations show that the Abraham general solvation model predicts the observed solubility behavior of anthracene, phenanthrene, and hexachlorobenzene to within an average absolute deviation of about ±35%.Key words: solubility predictions, organic solvents, nonelectrolyte solutes, partition coefficients.

Solubility of diphenyl sulfone in organic nonelectrolyte solvents. Comparison of observed versus predicted values based upon the general solvation model

1999 ◽  
Vol 77 (7) ◽  
pp. 1214-1217 ◽  
Author(s):  
Kristin A Fletcher ◽  
Carmen E Hernández ◽  
Lindsay E Roy ◽  
Karen S Coym ◽  
William E Acree, Jr.
Keyword(s):  
Organic Solvent ◽  
Organic Solvents ◽  
Predictive Ability ◽  
Molar Refraction ◽  
Solvation Model ◽  
Absolute Deviation ◽  
Diphenyl Sulfone ◽  
Solubility Behavior ◽  
Aqueous Solvent ◽  
Equilibrium Data

Experimental solubilities are reported for diphenyl sulfone dissolved in 8 alkane, 10 alcohol, and in aqueous solvent media at 25°C. Results of these measurements are used to test the predictive ability of the general solvation model log CA,orgsat/CA,aqsat = c + rR2 + sπ2H + aΣα2H + bΣβ2H + vVxwhere CA,orgsat and CA,aqsat refer to the solute solubility in the organic solvent and in water, respectively, R2 is the solute's excess molar refraction, Vx is the McGowan characteristic volume of the solute, π2H denotes the solute's dipolarity/ polarizability, and Σα2H and Σβ2H are the overall hydrogen-bond acidity and basicity descriptors for the solute. The remaining symbols in the above expression are known solvent coefficients, which have been determined previously through regressional analysis of published organic solvent - water partition coefficient and vapor-liquid equilibrium data. Computations show that the general solvation model predicts the solubility behavior of diphenyl sulfone in the 11 organic solvents for which predictions could be made to within an overall average absolute deviation of about ±20%. Key words: diphenyl sulfone solubilities, organic solvents, solubility predictions, general solvation model.

Solubility Behavior of 3,4,5-Trimethoxybenzaldehyde in Different Pure Organic Solvents

2021 ◽  
Author(s):  
Zihao Wang ◽  
Fumin Xue ◽  
Weichun Feng ◽  
Wenguo Xing ◽  
Baicheng Feng ◽  
...  
Keyword(s):  
Organic Solvents ◽  
Solubility Behavior

UNTERSUCHUNGEN ÜBER DIE EXTRAKTION DES ROTEN KOBER-FARBSTOFFS DURCH ORGANISCHE LÖSUNGSMITTEL ZUR ÖSTROGENBESTIMMUNG IM HARN

1960 ◽  
Vol XXXV (I) ◽  
pp. 34-48 ◽  
Author(s):  
Gerd Ittrich
Keyword(s):  
Menstrual Cycle ◽  
Organic Solvents ◽  
Urine Sample ◽  
Phenol Derivatives ◽  
Organische Lösungsmittel ◽  
Colour Complex

ABSTRACT A series of organic solvents and phenol derivatives have been examined for the extraction of the pink Kober-colour complex. Optimal results could be achieved for fluorimetry by a solution of 2 % (w/v) p-nitrophenol and 1 % (v/v) ethanol in acetylenetetrabromide, when the green mercury line (546 mμ was used as primary light. The sensitivity, stability and specificity have been improved, compared with the previously described reaction. By changing the sequence of purification steps and by reducing the volume of the urine sample (5 ml) the method for the determination of total oestrogens has been simplified. Approximately 10 determinations can be done within 3–4 hours by one person. Recovery experiments and comparative determinations with a previously described method have been carried out. The excretion of total oestrogens in a complete menstrual cycle is determined with the described method.

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