scholarly journals Crosslinkable polymeric contrast agent for high-resolution X-ray imaging of the vascular system

2020 ◽  
Vol 56 (44) ◽  
pp. 5885-5888 ◽  
Author(s):  
Ngoc An Le ◽  
Willy Kuo ◽  
Bert Müller ◽  
Vartan Kurtcuoglu ◽  
Bernhard Spingler
Keyword(s):  
Computed Tomography ◽  
High Resolution ◽  
Contrast Agent ◽  
Vascular System ◽  
Ex Vivo ◽  
Micro Computed Tomography ◽  
X Ray ◽  
X Ray Imaging ◽  
System P

A contrast agent for X-ray micro computed tomography (μCT), called XlinCA, that combines reliable perfusion and permanent retention and contrast properties, was developed for ex vivo imaging.

scholarly journals All Our Eggs In One Basket: Challenges of High Resolution X-Ray Micro-Computed Tomography of Great Auk Pinguinus impennis Eggshell

2018 ◽  
Vol 2 ◽  
pp. e25794
Author(s):  
Douglas Russell ◽  
Arianna Bernucci ◽  
Amy Scott-Murray ◽  
Duncan Jackson ◽  
Farah Ahmed ◽  
...  
Keyword(s):  
Computed Tomography ◽  
High Resolution ◽  
Structured Light ◽  
3D Models ◽  
Breeding Ecology ◽  
Micro Computed Tomography ◽  
History Museum ◽  
X Ray ◽  
X Ray Imaging ◽  
Scan Data

High resolution X-ray micro-computed tomography gives the ability to research objects in unprecedented detail in 3D without damaging them but applying these new techniques to specimens can be complex. In 2017 the Natural History Museum (NHM), London embarked on a ground-breaking project with University of Sheffield to compare extinct Great Auk Pinguinus impennis eggshell microstructure to that of their extant relatives to gain new insight into their breeding ecology. NHM has a ZEISS Xradia 520 Versa X-ray microscope capable of submicron X-ray imaging in 3D but using it required supporting and moving complete eggshells within the confined, potentially harsh, mechanised environment of the microscope without risk. Ensuring the correct position and orientation of each egg to image nine distinct areas on the eggshell was also a challenge. Collaboration with colleagues in the NHM Conservation and Imaging & Analysis Centres developed a bespoke solution to hold and protect the eggs during scanning. All six NHM Great Auk eggshells and the inside of the microscope were surface scanned using a handheld structured light scanner. Scan data produced 3D models from which accurate 3D printed plastic replicas were made of the three Great Auk eggs prioritised for research. Each replica was used to mould a two-part, custom-built, case for each egg constructed from conservation grade epoxy putty and lined with polyethylene foam. This provided close-fitting, durable cases which could be used for the 6-month duration of the project. Each case enclosed its matching Great Auk egg entirely and had the advantage of being rock-hard, electrically insulating and water, heat and chemical resistant. A system of three, interchangeable, tailor-made mounting brackets were designed that married with the cases and held them safely and precisely inside the microscope at the correct angles and positions for imaging. The structured light scan of the inside of the microscope was used to model the necessary rotational movements of the cases and brackets inside the scanner, ensuring that all movements had sufficient clearance to avoid risk of impact. This system successfully protected the fragile c. 200 year old eggs throughout 70 scanning sessions. This provides a methodology for high resolution X-ray micro-computed tomography imaging of any similarly sized, fragile, object.

scholarly journals High Resolution Imaging of Mouse Embryos and Neonates with X‐Ray Micro‐Computed Tomography

2019 ◽  
Vol 9 (2) ◽  
Author(s):  
Chih‐Wei Hsu ◽  
Sowmya Kalaga ◽  
Uchechukwu Akoma ◽  
Tara L. Rasmussen ◽  
Audrey E. Christiansen ◽  
...  
Keyword(s):  
Computed Tomography ◽  
High Resolution ◽  
Mouse Embryos ◽  
High Resolution Imaging ◽  
Micro Computed Tomography ◽  
X Ray ◽  
Resolution Imaging

Advances in High-Resolution X-Ray Computed Tomography: Comparing the Latest in Cabinet-based Micro-Computed Tomography Technologies and Synchrotron Radiation-Based Tomography Beamlines

2012 ◽  
Vol 18 (S2) ◽  
pp. 576-577 ◽  
Author(s):  
R. Rudolph ◽  
A. Williams ◽  
O. Brunke
Keyword(s):  
Computed Tomography ◽  
High Resolution ◽  
Synchrotron Radiation ◽  
Micro Computed Tomography ◽  
X Ray ◽  
X Ray Computed

Extended abstract of a paper presented at Microscopy and Microanalysis 2012 in Phoenix, Arizona, USA, July 29 – August 2, 2012.

Hybrid BaYbF5Nanoparticles: Novel Binary Contrast Agent for High-Resolution in Vivo X-ray Computed Tomography Angiography

2012 ◽  
Vol 1 (4) ◽  
pp. 461-466 ◽  
Author(s):  
Yanlan Liu ◽  
Kelong Ai ◽  
Jianhua Liu ◽  
Qinghai Yuan ◽  
Yangyang He ◽  
...  
Keyword(s):  
Computed Tomography ◽  
High Resolution ◽  
Contrast Agent ◽  
Computed Tomography Angiography ◽  
X Ray ◽  
X Ray Computed

scholarly journals LOTUS-inVivo Micro Computed Tomography System for Imaging of Small Animals and Ex-Vivo Biological Samples

2020 ◽  
Author(s):  
Mohammadreza Fouladi ◽  
Kamran Gholami ◽  
Hossein Ghadiri
Keyword(s):  
Computed Tomography ◽  
Biological Samples ◽  
Ex Vivo ◽  
Small Animal ◽  
Small Animals ◽  
Micro Ct ◽  
Ct Scanner ◽  
Micro Computed Tomography ◽  
Low Contrast ◽  
X Ray

X-ray Computed Tomography (CT), e.g. clinical CT scanners, basically provides Linear Attenuation Coefficients (LACs) of objects under study by the means of algorithmic reconstruction of acquired views of attenuated X-ray passing through the samples in different angles around the imaged sample. Micro Computed Tomography (micro-CT) basically works the same as clinical CT. It provides volumetric information representing the inner structure of objects with a resolution in the micron range. LOTUS-inVivo is a micro-CT scanner dedicated to imaging of small animals and ex-vivo biological samples. In the present study the spatial resolution and Low Contrast Detectability (LCD) of LOTUS-inVivo scanner were evaluated using standard phantoms. We aimed to prove the capability of LOTUS-inVivo for small animal and ex-vivo biological samples imaging using the measured image quality parameters, i.e. spatial resolution and low contrast detectability. By the means of analysis of bar and LCD phantom images, the limiting resolution of LOTUS-inVivo micro-CT scanner was measured about 2.7 µm and has been shown that it’s capable of resolving sizes greater than 12.5 µm. Also, we concluded that LOTUS-inVivo is capable of discriminating tissues with 3% differences in contrast relative to the background, for 1 mm bar size. Thus, the provided technical characteristics in this study have made LOTUS-inVivo as a suitable tool for small animal imaging.

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