Highly specific detection of Aβ oligomers in early Alzheimer's disease by a near-infrared fluorescent probe with a “V-shaped” spatial conformation

2020 ◽  
Vol 56 (4) ◽  
pp. 583-586 ◽  
Author(s):  
Jian Yang ◽  
Fantian Zeng ◽  
Xiaofang Li ◽  
Chongzhao Ran ◽  
Yungen Xu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Fluorescent Probe ◽  
Near Infrared ◽  
High Selectivity ◽  
Specific Detection ◽  
Aβ Oligomers ◽  
Early Alzheimer’S Disease

In this report, we demonstrate a “V-shaped” NIRF probe PTO-29, which can monitor Aβ oligomers with high selectivity.

A spiropyran-based fluorescent probe for the specific detection of β-amyloid peptide oligomers in Alzheimer's disease

2016 ◽  
Vol 52 (57) ◽  
pp. 8865-8868 ◽  
Author(s):  
Guanglei Lv ◽  
Anyang Sun ◽  
Peng Wei ◽  
Ning Zhang ◽  
Haichuang Lan ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Fluorescent Probe ◽  
Amyloid Peptide ◽  
Specific Detection ◽  
Aβ Oligomers ◽  
Β Amyloid ◽  
Β Amyloid Peptide

A fluorescent probe for the specific detection of Aβ oligomers in Alzheimer's disease both in vitro and in vivo was developed.

An activatable near-infrared fluorescent probe for methylglyoxal imaging in Alzheimer's disease mice

2020 ◽  
Vol 56 (5) ◽  
pp. 707-710 ◽  
Author(s):  
Yijing Dang ◽  
Fengyang Wang ◽  
Lingling Li ◽  
Yi Lai ◽  
Zhiai Xu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Fluorescent Probe ◽  
Near Infrared

A near-infrared fluorescent probe for MGO imaging in Alzheimer's disease mouse brains was developed.

Simultaneous imaging of mitochondrial viscosity and hydrogen peroxide in Alzheimer's disease by a single near-infrared fluorescent probe with a large Stokes shift

2020 ◽  
Vol 56 (7) ◽  
pp. 1050-1053 ◽  
Author(s):  
Songjiao Li ◽  
Peipei Wang ◽  
Wenqi Feng ◽  
Yunhui Xiang ◽  
Kun Dou ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Hydrogen Peroxide ◽  
Fluorescent Probe ◽  
Near Infrared ◽  
Stokes Shift ◽  
Large Stokes Shift ◽  
Simultaneous Imaging

Simultaneous imaging of mitochondrial viscosity and hydrogen peroxide in Alzheimer's disease by a single near-infrared fluorescent probe with a large Stokes shift.

scholarly journals Transferrin-Pep63-liposomes accelerate the clearance of Aβ and rescue impaired synaptic plasticity in early Alzheimer’s disease models

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Xiu Yang ◽  
Xu Li ◽  
Le Liu ◽  
Yuan-Hao Chen ◽  
Yue You ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Synaptic Plasticity ◽  
Neuroprotective Effect ◽  
Maze Task ◽  
Aβ Oligomers ◽  
Morris Water Maze Task ◽  
Amyloid Aβ ◽  
Early Alzheimer’S Disease ◽  
Soluble Aβ Oligomers

AbstractAlzheimer’s disease (AD) is characterized by aberrant accumulation of extracellular β-amyloid (Aβ) peptides in the brain. Soluble Aβ oligomers are thought to be the most neurotoxic species and are correlated with cognitive dysfunction in early AD. However, there is still no effective treatment so far. We determined that Pep63, a small peptide, had a neuroprotective effect on synaptic plasticity and memory in our previous study. Here, we developed novel and multifunctional liposomes targeting both Aβ oligomers and fibrils based on a liposome delivery system. Transferrin-Pep63-liposomes (Tf-Pep63-Lip), possessing the ability for blood-brain barrier targeting, were also incorporated with phosphatidic acid (PA) and loaded with neuroprotective Pep63. We discovered that administration of Tf-Pep63-Lip could significantly reduce the Aβ burden in the hippocampus, and improve cognitive deficits in 6-month-old APP/PS1 mice in the Morris-Water maze task and fear-conditioning test with the combined effects of PA and Pep63. Tf-Pep63-Lip could capture Aβ oligomers or fibrils and then facilitated microglial chemotaxis nearby for clearance. Simultaneously, Tf-Pep63-Lip hindered Aβ1-42 aggregation and disaggregated Aβ1-42 assembly due to multivalent PA-Aβ. Pep63 effectively inhibited the binding between EphB2 and Aβ oligomers after release from liposomes and rescued NMDA receptors trafficking, the basis of synaptic plasticity. No side effects were observed in either APP/PS1 or wild-type mice, indicating that Tf-Pep63-Lip might be safe under the dosing regimen used in our experiment. Taken together, our results suggested that Tf-Pep63-Lip may serve as a safe and efficient agent for AD combination therapy.

A novel near-infrared fluorescent probe for detection of early-stage Aβ protofibrils in Alzheimer's disease

2020 ◽  
Vol 56 (11) ◽  
pp. 1625-1628 ◽  
Author(s):  
Guanglei Lv ◽  
Anyang Sun ◽  
Minqi Wang ◽  
Peng Wei ◽  
Ruohan Li ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Fluorescent Probe ◽  
Near Infrared ◽  
Early Stage

Detection of Aβ protofibrils at the early stage of Alzheimer's disease was realized by a novel near-infrared probe (DCM-AN) based on dicyanomethylene-4H-pyran.

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