An activatable near-infrared fluorescent probe for methylglyoxal imaging in Alzheimer's disease mice

2020 ◽  
Vol 56 (5) ◽  
pp. 707-710 ◽  
Author(s):  
Yijing Dang ◽  
Fengyang Wang ◽  
Lingling Li ◽  
Yi Lai ◽  
Zhiai Xu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Fluorescent Probe ◽  
Near Infrared

A near-infrared fluorescent probe for MGO imaging in Alzheimer's disease mouse brains was developed.

Simultaneous imaging of mitochondrial viscosity and hydrogen peroxide in Alzheimer's disease by a single near-infrared fluorescent probe with a large Stokes shift

2020 ◽  
Vol 56 (7) ◽  
pp. 1050-1053 ◽  
Author(s):  
Songjiao Li ◽  
Peipei Wang ◽  
Wenqi Feng ◽  
Yunhui Xiang ◽  
Kun Dou ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Hydrogen Peroxide ◽  
Fluorescent Probe ◽  
Near Infrared ◽  
Stokes Shift ◽  
Large Stokes Shift ◽  
Simultaneous Imaging

Simultaneous imaging of mitochondrial viscosity and hydrogen peroxide in Alzheimer's disease by a single near-infrared fluorescent probe with a large Stokes shift.

Highly specific detection of Aβ oligomers in early Alzheimer's disease by a near-infrared fluorescent probe with a “V-shaped” spatial conformation

2020 ◽  
Vol 56 (4) ◽  
pp. 583-586 ◽  
Author(s):  
Jian Yang ◽  
Fantian Zeng ◽  
Xiaofang Li ◽  
Chongzhao Ran ◽  
Yungen Xu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Fluorescent Probe ◽  
Near Infrared ◽  
High Selectivity ◽  
Specific Detection ◽  
Aβ Oligomers ◽  
Early Alzheimer’S Disease

In this report, we demonstrate a “V-shaped” NIRF probe PTO-29, which can monitor Aβ oligomers with high selectivity.

A novel near-infrared fluorescent probe for detection of early-stage Aβ protofibrils in Alzheimer's disease

2020 ◽  
Vol 56 (11) ◽  
pp. 1625-1628 ◽  
Author(s):  
Guanglei Lv ◽  
Anyang Sun ◽  
Minqi Wang ◽  
Peng Wei ◽  
Ruohan Li ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Fluorescent Probe ◽  
Near Infrared ◽  
Early Stage

Detection of Aβ protofibrils at the early stage of Alzheimer's disease was realized by a novel near-infrared probe (DCM-AN) based on dicyanomethylene-4H-pyran.

scholarly journals Near-infrared Fluorescence Ocular Imaging (NIRFOI) of Alzheimer’s Disease

2018 ◽  
Vol 21 (1) ◽  
pp. 35-43 ◽  
Author(s):  
Jian Yang ◽  
Jing Yang ◽  
Yuyan Li ◽  
Yungen Xu ◽  
Chongzhao Ran
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Near Infrared ◽  
Near Infrared Fluorescence ◽  
Ocular Imaging

scholarly journals Photobiomodulation for Alzheimer’s Disease: Has the Light Dawned?

Photonics ◽  
2019 ◽  
Vol 6 (3) ◽  
pp. 77 ◽  
Author(s):  
Michael Hamblin
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Clinical Trials ◽  
Near Infrared ◽  
Infrared Light ◽  
Western World ◽  
Diverse Range ◽  
Non Invasive ◽  
Dementia Patients ◽  
Relieve Pain

Next to cancer, Alzheimer’s disease (AD) and dementia is probably the most worrying health problem facing the Western world today. A large number of clinical trials have failed to show any benefit of the tested drugs in stabilizing or reversing the steady decline in cognitive function that is suffered by dementia patients. Although the pathological features of AD consisting of beta-amyloid plaques and tau tangles are well established, considerable debate exists concerning the genetic or lifestyle factors that predispose individuals to developing dementia. Photobiomodulation (PBM) describes the therapeutic use of red or near-infrared light to stimulate healing, relieve pain and inflammation, and prevent tissue from dying. In recent years PBM has been applied for a diverse range of brain disorders, frequently applied in a non-invasive manner by shining light on the head (transcranial PBM). The present review discusses the mechanisms of action of tPBM in the brain, and summarizes studies that have used tPBM to treat animal models of AD. The results of a limited number of clinical trials that have used tPBM to treat patients with AD and dementia are discussed.

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