A new type of composite MOFs based on high-valent Sb(v)-based units and cuprous-halide clusters

2019 ◽  
Vol 55 (100) ◽  
pp. 15113-15116 ◽  
Author(s):  
Li-Dan Lin ◽  
Zhong Li ◽  
Jin-Hua Liu ◽  
Yan-Qiong Sun ◽  
Xin-Xiong Li ◽  
...  
Keyword(s):  
New Class ◽  
New Type ◽  
High Valent ◽  
First Time

In this work, an unusual high-valent Sb(v)-based [SbL2]− unit was developed for the first time to combine with various cuprous-halide clusters for the construction of a brand-new class of heterometallic MOFs.

A Relationship Between the Factor Indivisibility and the Output Elasticity of the Indivisible Factor

2021 ◽  
pp. 232102222098516
Author(s):  
Dipankar Das
Keyword(s):  
Production Function ◽  
Limit Point ◽  
Mathematical Proof ◽  
Wage Equation ◽  
Marginal Value ◽  
Output Elasticity ◽  
New Type ◽  
First Time ◽  
Jel Classifications

The paper puts forth a notion and derives a special type of production function where labour is an indivisible factor and is in the integer space. Thus, Newtonian calculus is not an appropriate method of deriving the marginal value because limit point does not exist. This shows that indivisibility determines the output elasticity. In the first part, the paper propounds a notion regarding how indivisibility determines curvature of the production function. In the second part, the paper incorporates the findings within a production function and derives a new type accordingly. Moreover, it formally derives the standard wage equation considering all the entitlements of labour, namely (a) normal wages, (b) interest and (c) rent of ability. So far, no such mathematical proof is there to support this wage composition. This paper, for the first time, derives this wage equation considering indivisibility of labour. JEL Classifications: J23, J24, J31, D24, C61, E24, L8

scholarly journals The antimicrobial potential of cannabidiol

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Mark A. T. Blaskovich ◽  
Angela M. Kavanagh ◽  
Alysha G. Elliott ◽  
Bing Zhang ◽  
Soumya Ramu ◽  
...  
Keyword(s):  
Bacterial Infections ◽  
Modern Medicine ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
New Class ◽  
Clostridioides Difficile ◽  
Excellent Activity ◽  
Induce Resistance ◽  
First Time

AbstractAntimicrobial resistance threatens the viability of modern medicine, which is largely dependent on the successful prevention and treatment of bacterial infections. Unfortunately, there are few new therapeutics in the clinical pipeline, particularly for Gram-negative bacteria. We now present a detailed evaluation of the antimicrobial activity of cannabidiol, the main non-psychoactive component of cannabis. We confirm previous reports of Gram-positive activity and expand the breadth of pathogens tested, including highly resistant Staphylococcus aureus, Streptococcus pneumoniae, and Clostridioides difficile. Our results demonstrate that cannabidiol has excellent activity against biofilms, little propensity to induce resistance, and topical in vivo efficacy. Multiple mode-of-action studies point to membrane disruption as cannabidiol’s primary mechanism. More importantly, we now report for the first time that cannabidiol can selectively kill a subset of Gram-negative bacteria that includes the ‘urgent threat’ pathogen Neisseria gonorrhoeae. Structure-activity relationship studies demonstrate the potential to advance cannabidiol analogs as a much-needed new class of antibiotics.

scholarly journals Phenotypic Susceptibility to Bevirimat in Isolates from HIV-1-Infected Patients without Prior Exposure to Bevirimat

2010 ◽  
Vol 54 (6) ◽  
pp. 2345-2353 ◽  
Author(s):  
Nicolas A. Margot ◽  
Craig S. Gibbs ◽  
Michael D. Miller
Keyword(s):  
Recombinant Viruses ◽  
Gag Polyprotein ◽  
New Class ◽  
Major Mutation ◽  
Hiv Drugs ◽  
The Impact ◽  
First Time ◽  
Hiv 1

ABSTRACT Bevirimat (BVM) is the first of a new class of anti-HIV drugs with a novel mode of action known as maturation inhibitors. BVM inhibits the last cleavage of the Gag polyprotein by HIV-1 protease, leading to the accumulation of the p25 capsid-small peptide 1 (SP1) intermediate and resulting in noninfectious HIV-1 virions. Early clinical studies of BVM showed that over 50% of the patients treated with BVM did not respond to treatment. We investigated the impact of prior antiretroviral (ARV) treatment and/or natural genetic diversity on BVM susceptibility by conducting in vitro phenotypic analyses of viruses made from patient samples. We generated 31 recombinant viruses containing the entire gag and protease genes from 31 plasma samples from HIV-1-infected patients with (n = 21) or without (n = 10) prior ARV experience. We found that 58% of the patient isolates tested had a >10-fold reduced susceptibility to BVM, regardless of the patient's ARV experience or the level of isolate resistance to protease inhibitors. Analysis of mutants with site-directed mutations confirmed the role of the V370A SP1 polymorphism (SP1-V7A) in resistance to BVM. Furthermore, we demonstrated for the first time that a capsid polymorphism, V362I (CA protein-V230I), is also a major mutation conferring resistance to BVM. In contrast, none of the previously defined resistance-conferring mutations in Gag selected in vitro (H358Y, L363M, L363F, A364V, A366V, or A366T) were found to occur among the viruses that we analyzed. Our results should be helpful in the design of diagnostics for prediction of the potential benefit of BVM treatment in HIV-1-infected patients.

scholarly journals A Novel Six-Rhodopsin System in a Single Archaeon

2010 ◽  
Vol 192 (22) ◽  
pp. 5866-5873 ◽  
Author(s):  
Hsu-Yuan Fu ◽  
Yu-Cheng Lin ◽  
Yung-Ning Chang ◽  
Hsiaochu Tseng ◽  
Ching-Che Huang ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Global Environment ◽  
Diverse Group ◽  
Ion Transporters ◽  
Haloarcula Marismortui ◽  
Resource Limited ◽  
New Type ◽  
Ion Transportation ◽  
Proton Transporters ◽  
First Time

ABSTRACT Microbial rhodopsins, a diverse group of photoactive proteins found in Archaea, Bacteria, and Eukarya, function in photosensing and photoenergy harvesting and may have been present in the resource-limited early global environment. Four different physiological functions have been identified and characterized for nearly 5,000 retinal-binding photoreceptors, these being ion transporters that transport proton or chloride and sensory rhodopsins that mediate light-attractant and/or -repellent responses. The greatest number of rhodopsins previously observed in a single archaeon had been four. Here, we report a newly discovered six-rhodopsin system in a single archaeon, Haloarcula marismortui, which shows a more diverse absorbance spectral distribution than any previously known rhodopsin system, and, for the first time, two light-driven proton transporters that respond to the same wavelength. All six rhodopsins, the greatest number ever identified in a single archaeon, were first shown to be expressed in H. marismortui, and these were then overexpressed in Escherichia coli. The proteins were purified for absorption spectra and photocycle determination, followed by measurement of ion transportation and phototaxis. The results clearly indicate the existence of a proton transporter system with two isochromatic rhodopsins and a new type of sensory rhodopsin-like transducer in H. marismortui.

Research on the Key Technologies for New Large Dual-Platen High-Precision Clamping System

2010 ◽  
Vol 97-101 ◽  
pp. 64-68
Author(s):  
Jian Chen ◽  
Jin Wang ◽  
Guo Dong Lu ◽  
Zheng Qi Ling
Keyword(s):  
High Precision ◽  
Large Scale ◽  
New Technologies ◽  
Impact Factors ◽  
Adaptive Correction ◽  
Hydraulic Servo ◽  
New Type ◽  
Clamping System ◽  
Plastic Parts ◽  
First Time

High- precision and large scale are the developing trend for injection molding machine clamping system .This paper compared the characteristics of three-platen toggle and dual-platen hydraulic clamping system. The key impact factors that effecting plastic parts` precision from clamping system were discussed systematically first time. Based on these analyses, a new clamping system has been proposed and manufactured to improve the plastics parts` precision, including three new technologies: new type dual-platen structure, parallelism adaptive correction technology and numerical controlled hydraulic servo system technology. It has been applied in practical machine successfully, and experiment result proves that it is effective enough to satisfying the high-precision molding of large plastics parts.

Production and Technical Characteristics of a New Class of Amorphous Metals

1995 ◽  
Vol 400 ◽  
Author(s):  
R.T. Malkhassian
Keyword(s):  
Amorphous Phase ◽  
Quantum Chemical ◽  
New Technology ◽  
Chemical Technology ◽  
Quantum Level ◽  
Vibrationally Excited ◽  
New Class ◽  
The Third ◽  
Hydrogen Molecules ◽  
First Time

AbstractA new technology for obtainment of amorphous single-component metals is presented.For the first time the reduction of molybdenum oxide with formation of its amorphous phase is realized in conditions of a given quantum-chemical technology by means of vibrationally excited to the third quantum level hydrogen molecules with 1.5 ± 0.2 eV energy. The evidences of formation of this nonequilibrium amorphous phase are presented along with certain physicochemical properties of the obtained amorphous molybdenum.A model is proposed for the origin of amorphous phase under the influence of nonequilibrium quantum-chemical technology.

Theoretical Studies of the Physical Properties of Rodlike and Related Polymers

1988 ◽  
Vol 134 ◽  
Author(s):  
W. J. Welsh ◽  
J. E. Mark ◽  
Y. Yang ◽  
G. P. Das
Keyword(s):  
High Performance ◽  
Liquid Crystalline ◽  
Theoretical Work ◽  
Environmental Resistance ◽  
New Class ◽  
Protonated Forms ◽  
New Type ◽  
Electrooptical Properties ◽  
Cis And Trans ◽  
Strong Acids

ABSTRACTThis review focuses on a new type of para-catenated aromatic polymer being used in the preparation of high-performance films and fibers of exceptional strength, thermal stability, and environmental resistance, including inertness to essentially all common solvents. Polymers of this type include the cis- and trans-poly(p-phenylene benzobisoxazole) (PBO), the cis- and trans-forms of the corresponding poly(pphenylene benzobisthiazole) (PBT), and the structurally similar poly(5,5ʹ-bibenzoxazole-2.2ʹ-diyl-l,3-phenylene) (AAPBO) and poly(2,5-benzoxazole) (ABPBO) and their sulfurcontaining analogues. Because of their rigidity, these polymers become highly oriented in solution and some display liquid crystalline behavior. The purpose of this paper is to summarize the authorsʹ theoretical work on the structures, conformational energies, intermolecular interactions, electronic properties, electrical conductivity, and electrooptical properties of these chains, including, in some cases, the so-called articulated forms and the protonated forms known to exist in strong acids. The emphasis is on how such studies provide a molecular understanding of the unusual properties and processing characteristics of this new class of materials.

Some Origins of Nationalism in East Africa

1968 ◽  
Vol 9 (1) ◽  
pp. 119-146 ◽  
Author(s):  
J. M. Lonsdale
Keyword(s):  
Central Government ◽  
Colonial Period ◽  
Political Activity ◽  
Colonial Rule ◽  
Face To Face ◽  
National Movements ◽  
New Type ◽  
First Time ◽  
Official Recognition

This paper attempts to provide a frame of reference for evaluating the role of ordinary rural Africans in national movements, in the belief that scholarly preoccupation with élites will only partially illumine the mainsprings of nationalism. Kenya has been taken as the main field of enquiry, with contrasts and comparisons drawn from Uganda and Tanganyika. The processes of social change are discussed with a view to establishing that by the end of the colonial period one can talk of peasants rather than tribesmen in some of the more progressive areas. This change entailed a decline in the leadership functions of tribal chiefs who were also the official agents of colonial rule, but did not necessarily mean the firm establishment of a new type of rural leadership. The central part of the paper is taken up with an account of the competition between these older and newer leaderships, for official recognition rather than a mass following. A popular following was one of the conditions for such recognition, but neither really achieved this prior to 1945 except in Kikuyuland, and there the newer leaders did not want official recognition. After 1945 the newer leadership, comprising especially traders and officials of marketing co-operatives, seems everywhere to have won a properly representative position, due mainly to the enforced agrarian changes which brought the peasant face to face with the central government, perhaps for the first time. This confrontation, together with the experience of failure in earlier and more local political activity, resulted in a national revolution coalescing from below, co-ordinated rather than instigated by the educated élite.

A New Class of Oxide Superconductor (Nd, Ce, Sr)2CuO4

1989 ◽  
Vol 156 ◽  
Author(s):  
E. Takayama-Muromachi
Keyword(s):  
Crystal Structure ◽  
Crystal Chemistry ◽  
Superconducting Phase ◽  
Type Structure ◽  
Oxide Superconductor ◽  
New Class ◽  
System 2 ◽  
New Type ◽  
System 1 ◽  
Tetragonal Cell

ABSTRACTSince the discovery of the high-Tc superconductor in the La-Ba-Cu-O system [1], a great deal of experimental and theoretical effort have been made to clarify the nature of the Cu-based oxides. In order to elucidate mechanism of the high-Tc superconductivity, discovery of a new type of superconductor is no doubt of great importance. Recently, Akimitsu et al. found a new oxide superconductor in the Nd-Ce-Sr-Cu-O system [2]. Soon after their discovery, the superconducting phase was isolated and identified [3]. It has a tetragonal cell with space group P4/nmm and has a structure closely related to but different from the K2NiF4− or T'-Nd2CuO4− -type structure. Although, Tc of the Nd-Ce-Sr-Cu oxide is not so high (ca. 20 K) compared with the 1–2–3 or Bi(Tl)-based superconductors, it has aroused interest widely due to a very simple crystal structure. In this article, I will discuss superconductivity and crystal chemistry of the Nd-Ce-Sr-Cu oxide. Also, various compounds isostructural to it will be presented.

Allee’s Effect Bifurcation in Generalized Logistic Maps

2019 ◽  
Vol 29 (03) ◽  
pp. 1950039
Author(s):  
J. Leonel Rocha ◽  
Abdel-Kaddous Taha
Keyword(s):  
Allee Effect ◽  
Dynamical Behavior ◽  
Complete Classification ◽  
Unimodal Maps ◽  
New Class ◽  
New Type ◽  
Local And Global Bifurcations ◽  
One Dimensional Maps ◽  
Necessary And Sufficient

This paper concerns the study of the Allee effect on the dynamical behavior of a new class of generalized logistic maps. The fundamentals of the dynamics of this 4-parameter family of one-dimensional maps are presented. A complete classification of the nature and stability of its fixed points is provided. The main results relate to the Allee effect bifurcation: a new type of bifurcation introduced for this class of unimodal maps. A necessary and sufficient condition so that the Allee fixed point is a snap-back repeller is established. In addition, in the parameters space is defined an Allee’s effect region, which determines the existence of an essential extinction for the generalized logistic maps. Local and global bifurcations of generalized logistic maps are investigated.

Sign in / Sign up

Export Citation Format

Share Document