Production and Technical Characteristics of a New Class of Amorphous Metals

1995 ◽  
Vol 400 ◽  
Author(s):  
R.T. Malkhassian
Keyword(s):  
Amorphous Phase ◽  
Quantum Chemical ◽  
New Technology ◽  
Chemical Technology ◽  
Quantum Level ◽  
Vibrationally Excited ◽  
New Class ◽  
The Third ◽  
Hydrogen Molecules ◽  
First Time

AbstractA new technology for obtainment of amorphous single-component metals is presented.For the first time the reduction of molybdenum oxide with formation of its amorphous phase is realized in conditions of a given quantum-chemical technology by means of vibrationally excited to the third quantum level hydrogen molecules with 1.5 ± 0.2 eV energy. The evidences of formation of this nonequilibrium amorphous phase are presented along with certain physicochemical properties of the obtained amorphous molybdenum.A model is proposed for the origin of amorphous phase under the influence of nonequilibrium quantum-chemical technology.

scholarly journals The antimicrobial potential of cannabidiol

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Mark A. T. Blaskovich ◽  
Angela M. Kavanagh ◽  
Alysha G. Elliott ◽  
Bing Zhang ◽  
Soumya Ramu ◽  
...  
Keyword(s):  
Bacterial Infections ◽  
Modern Medicine ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
New Class ◽  
Clostridioides Difficile ◽  
Excellent Activity ◽  
Induce Resistance ◽  
First Time

AbstractAntimicrobial resistance threatens the viability of modern medicine, which is largely dependent on the successful prevention and treatment of bacterial infections. Unfortunately, there are few new therapeutics in the clinical pipeline, particularly for Gram-negative bacteria. We now present a detailed evaluation of the antimicrobial activity of cannabidiol, the main non-psychoactive component of cannabis. We confirm previous reports of Gram-positive activity and expand the breadth of pathogens tested, including highly resistant Staphylococcus aureus, Streptococcus pneumoniae, and Clostridioides difficile. Our results demonstrate that cannabidiol has excellent activity against biofilms, little propensity to induce resistance, and topical in vivo efficacy. Multiple mode-of-action studies point to membrane disruption as cannabidiol’s primary mechanism. More importantly, we now report for the first time that cannabidiol can selectively kill a subset of Gram-negative bacteria that includes the ‘urgent threat’ pathogen Neisseria gonorrhoeae. Structure-activity relationship studies demonstrate the potential to advance cannabidiol analogs as a much-needed new class of antibiotics.

Early Permian fossil vertebrate footprints and their stratigraphic setting in megacyclic sequence II red beds, Prim Point, Prince Edward Island

1989 ◽  
Vol 26 (3) ◽  
pp. 591-605 ◽  
Author(s):  
David J. Mossman ◽  
Craig H. Place
Keyword(s):  
Central Europe ◽  
Prince Edward Island ◽  
River Sediments ◽  
Early Permian ◽  
Red Beds ◽  
Sparse Vegetation ◽  
The Third ◽  
Fossil Vertebrate ◽  
Crevasse Splay ◽  
First Time

Vertebrate trace fossils are reported for the first time from red beds near the top of megacyclic sequence II at Prim Point in southwestern Prince Edward Island. They occur as casts of tetrapod trackways. The ichnocoenose also includes a rich invertebrate ichnofauna. The trackmakers thrived in an area of sparse vegetation and occupied out-of-channel river sediments, most likely crevasse-splay deposits.Amphisauropus latus, represented by three trackways, has been previously reported from Germany, Poland, and Czechoslovakia. It is here interpreted as the track of a cotylosaur. It occurs together with the track of Gilmoreichnus kablikae, which is either a captorhinomorph or possibly a juvenile pelycosaur. These facilitate the assignment of a late Early Permian (late Autunian) age to the strata. The third set of footprints, those of a small herbivorous pelycosaur, compare most closely with Ichniotherium willsi, known hitherto from the Keele beds (latest Stephanian) of the English Midlands.This ichnocoenose occurs in a plate-tectonically rafted segment of crust stratigraphically equivalent to the same association of ichnofauna in the English Midlands and central Europe. The community occupied piedmont-valley-flat red beds within the molasse facies of Variscan uplands.

scholarly journals Phenotypic Susceptibility to Bevirimat in Isolates from HIV-1-Infected Patients without Prior Exposure to Bevirimat

2010 ◽  
Vol 54 (6) ◽  
pp. 2345-2353 ◽  
Author(s):  
Nicolas A. Margot ◽  
Craig S. Gibbs ◽  
Michael D. Miller
Keyword(s):  
Recombinant Viruses ◽  
Gag Polyprotein ◽  
New Class ◽  
Major Mutation ◽  
Hiv Drugs ◽  
The Impact ◽  
First Time ◽  
Hiv 1

ABSTRACT Bevirimat (BVM) is the first of a new class of anti-HIV drugs with a novel mode of action known as maturation inhibitors. BVM inhibits the last cleavage of the Gag polyprotein by HIV-1 protease, leading to the accumulation of the p25 capsid-small peptide 1 (SP1) intermediate and resulting in noninfectious HIV-1 virions. Early clinical studies of BVM showed that over 50% of the patients treated with BVM did not respond to treatment. We investigated the impact of prior antiretroviral (ARV) treatment and/or natural genetic diversity on BVM susceptibility by conducting in vitro phenotypic analyses of viruses made from patient samples. We generated 31 recombinant viruses containing the entire gag and protease genes from 31 plasma samples from HIV-1-infected patients with (n = 21) or without (n = 10) prior ARV experience. We found that 58% of the patient isolates tested had a >10-fold reduced susceptibility to BVM, regardless of the patient's ARV experience or the level of isolate resistance to protease inhibitors. Analysis of mutants with site-directed mutations confirmed the role of the V370A SP1 polymorphism (SP1-V7A) in resistance to BVM. Furthermore, we demonstrated for the first time that a capsid polymorphism, V362I (CA protein-V230I), is also a major mutation conferring resistance to BVM. In contrast, none of the previously defined resistance-conferring mutations in Gag selected in vitro (H358Y, L363M, L363F, A364V, A366V, or A366T) were found to occur among the viruses that we analyzed. Our results should be helpful in the design of diagnostics for prediction of the potential benefit of BVM treatment in HIV-1-infected patients.

Early (Avant-garde) Symphonies by Valentin Silvestrov As a Sound Universe

2021 ◽  
Vol 66 (1) ◽  
pp. 329-343
Author(s):  
Liudmyla Shapovalova ◽  
Іryna Romaniuk ◽  
Marianna Chernyavska ◽  
Svitlana Shchelkanova
Keyword(s):  
20Th Century ◽  
Human Being ◽  
Accurate Identification ◽  
Philosophy Of Music ◽  
Philosophical Concept ◽  
Avant Garde ◽  
The Third ◽  
Ninth Symphony ◽  
Human Ontology ◽  
First Time

"In the article under consideration are the ways of symphony genre transformation in the early works of Valentin Silvestrov (Ukraine). For the first time, the First, Second, Third, and Fourth symphonies by the genius composers of the 20th century are analyzed as a certain stylistic system. These compositions are endowed with the features of avant-garde poetics, and as a subject of musicological reflection, they are associated with a rethinking of the semantic paradigm of the genre. V. Silvestrov's early symphonies stand out from the classical practice of European symphonies. Scientific awareness of their phenomenal nature necessitated a methodological choice aimed at the most accurate identification of the philosophical concept of the new sound universum of V. Silvestrov's music. Deep correlation of the image of a human being as a factor of the symphony poetics (the influence of philosophical concepts of human ontology in the 20th century with the transformation of the genre canon) is considered. This refers to the nonmusical dimension of the genre semantics. The study of V. Silvestrov's early symphonies reveal a new philosophy of music through gradual movement – modulation: from the neo-baroque First Symphony and ""cosmic pastorals"" Musica Mundana of the Second Symphony through the history anthropologisation in the Third Symphony ""Eschatology"" to the monodrama Musica Humana in the Fourth Symphony. The dichotomy of Musica Mundana – Musica Humana is not accidental: in V. Silvestrov's creative method, remains relevant, which is confirmed by the dramaturgy of his latest work – the Ninth symphony (2019). Keywords: V. Silvestrov's early symphonies, evolution of style, worldview, Musica Mundana, monodrama. "

Render unto Caesar Just a Little Bit Longer: The Relationship between Constitutional Reforms and Executive Survival

2021 ◽  
pp. 1-22
Author(s):  
Tofigh Maboudi ◽  
Ghazal P. Nadi ◽  
Todd A. Eisenstadt
Keyword(s):  
Term Limits ◽  
Institutional Constraints ◽  
Third Wave ◽  
Political Leaders ◽  
Constitutional Order ◽  
The Third ◽  
Constitutional Reforms ◽  
The Impact ◽  
First Time ◽  
The Relationship

Abstract Since the third wave of democracy, term limits have become a popular fixture of most constitutions intended to constrain the executive. Yet, recent constitutional reforms around the world show that presidents seeking re-election sometimes overturn the entire constitutional order to extend their power. What is the impact of these constitutional manipulations on the longevity of the executive in office? Using survival analysis of all political leaders and national constitutions from 1875 to 2015, this article demonstrates, for the first time, that when ‘authoritarian-aspiring’ presidents remove constitutional term limits, they increase their stay in office by more than 40%. Our findings contrast with a widely held position in the comparative authoritarian literature suggesting that dictators survive longer under institutional constraints. On the contrary, we argue that by removing constitutional barriers, rulers consolidate more power at the expense of their most ambitious allies and can stay in power longer.

FACES OF V.M. SHUKSHIN: MARTIN IDEN, HAMLET, STEPAN RAZIN

2021 ◽  
pp. 59-65
Author(s):  
Т.А. Богумил
Keyword(s):  
Early Stage ◽  
Socialist Realism ◽  
Crowding Out ◽  
Behavioral Models ◽  
Cluster Approach ◽  
Second Stage ◽  
The Third ◽  
Third Stage ◽  
Early Departure ◽  
First Time

В статье предлагается концепция жизни и творческого роста В.М. Шукшина сквозь призму тезаурусного и кластерного подходов. Объяснительными «персональными моделями» для интерпретации биографического текста писателя являются кластеры Мартина Идена, Гамлета и Степана Разина. Ранее биографы и литературоведы указывали на важность этих персон для Шукшина, но разрозненно. Впервые предпринята попытка свести указанные персональные модели воедино, в целостный сюжет становления писателя в пространстве культуры. На разных этапах эволюции автора доминирует одна из указанных моделей, последовательно сменяя друг друга, но не вытесняя, а «внахлест». Ранний этап творчества, ориентированный на стратегию Мартина Идена, является попыткой «вписаться» в наличный культурный мейнстрим. Выражено это в следовании поэтике соцреализма. Второй этап подспудно начинается с реабилитации отца Шукшина в 1956 года, когда актуализируется «гамлетовский комплекс», проявляющийся в чувстве вины перед отцом, через стратегию утаивания подлинного «я», мотивы чудаковатости. Третий этап связан с личностью реального исторического лица, Степана Разина, и выражается в открытом протесте против власти. Все важные для В.М. Шукшина поведенческие модели объединены мотивом одинокого противостояния враждебному социуму и имеют трагический финал, что обусловило ранний уход писателя и порождение мифов о насильственном характере его смерти. В.М. Шукшин одновременно был фигурой неординарной и типичной, что позволило его биографии стать «персональной моделью» для последующих авторов, выходцев из сельской глубинки. The article proposes the concept of life and creative growth of V.M. Shukshin through the prism of the thesaurus and cluster approach. The explanatory "personal models" for interpreting the biographical text of the writer are clusters of Martin Eden, Hamlet and Stepan Razin. Earlier, biographers and literary critics pointed out the importance of these people for Shukshin, but it was scattered. For the first time, an attempt was made to bring these personal models together into an integral plot of the formation of the writer in the space of culture. At different stages of the writer’s evolution, one of these models dominates, successively replacing each other, but not crowding out, but “overlapping”. The early stage of creativity, focused on Martin Eden’s strategy, is an attempt to “fit in” the current cultural mainstream. This is expressed in following the poetics of socialist realism. The second stage implicitly begins with the rehabilitation of Shukshin’s father in 1956, when the “Hamletian complex” is actualized. It is manifested in a sense of guilt towards his father, the strategy of concealing the true “I”, eccentricities. The third stage is connected with the personality of a real historical person, Stepan Razin, and is expressed in an open protest against the authorities. All important for V.M. Shukshin's behavioral models are united by the motive of a lonely confrontation with a hostile society and have a tragic ending, which led to the early departure of the writer and the generation of myths about the violent nature of his death. V.M. Shukshin was an extraordinary and typical figure at the same time. That allowed his biography to become a “personal model” for subsequent authors who came from the rural outback.

ISOTOPE-GEOCHEMICAL FEATURES OF AUTHENIC CARBONATES OF THE YU1 PRODUCING HORIZON OF THE VERKH-TARSKOYE OIL FIELD (SOUTH OF WESTERN SIBERIA)

2020 ◽  
pp. 20-28
Author(s):  
L. G. Vakulenko ◽  
◽  
O. D. Nikolenko ◽  
D. A. Novikov ◽  
P. A. Yan ◽  
...  
Keyword(s):  
Isotopic Composition ◽  
Carbonate Rocks ◽  
Western Siberia ◽  
Oil Field ◽  
Third Generation ◽  
The Third ◽  
First Time ◽  
Different Sources ◽  
Sources Of Co2 ◽  
Comprehensive Study

A comprehensive study of the composition of sand and silt deposits of the Yu1 horizon of the Vasyuganskaya Formation upper part of the Verkh-Tarskoye oil field has been carried out. Associations of authigenic minerals have been determined in their cement, among which the calcite is the most widespread. According to petrographic parameters, three generations of calcite have been identified for which detailed isotopicgeochemical and ultramicroscopic studies were carried out for the first time. Wide and multi directional changes in the isotopic composition of carbon and oxygen and in the chemical composition of carbonate minerals were recorded, they indicate significant variations in the conditions of diagenesis and catagenesis, primarily temperature, and different sources of CO2. Significant variations in the isotopic composition of formation waters and its relationship with the isotopic composition of carbonates have been established. Thus, a narrow interval of close δ13C values was revealed, amounting to –10.5 to –9.1 ‰ in the formation waters of group II, and from –10.7 to –9.1 ‰ in calcites of the third generation. The source of CO2 in this system should be considered a carbon dioxide, which is formed in the process of metamorphism of carbonate rocks of the Paleozoic age.

scholarly journals Quantum Gravity at the Corner

Universe ◽  
2018 ◽  
Vol 4 (10) ◽  
pp. 107 ◽  
Author(s):  
Laurent Freidel ◽  
Alejandro Perez
Keyword(s):  
Quantum Gravity ◽  
Symplectic Form ◽  
Direct Application ◽  
Quantum Geometry ◽  
Quantum Level ◽  
Gravitational System ◽  
Gauge Transformations ◽  
First Order ◽  
Conformal Field ◽  
First Time

We investigate the quantum geometry of a 2d surface S bounding the Cauchy slices of a 4d gravitational system. We investigate in detail for the first time the boundary symplectic current that naturally arises in the first-order formulation of general relativity in terms of the Ashtekar–Barbero connection. This current is proportional to the simplest quadratic form constructed out of the pull back to S of the triad field. We show that the would-be-gauge degrees of freedo arising from S U ( 2 ) gauge transformations plus diffeomorphisms tangent to the boundary are entirely described by the boundary 2-dimensional symplectic form, and give rise to a representation at each point of S of S L ( 2 , R ) × S U ( 2 ) . Independently of the connection with gravity, this system is very simple and rich at the quantum level, with possible connections with conformal field theory in 2d. A direct application of the quantum theory is modelling of the black horizons in quantum gravity.

Fatigue Damage From High Mode Number Vortex-Induced Vibration

2006 ◽  
Author(s):  
J. Kim Vandiver ◽  
Susan B. Swithenbank ◽  
Vivek Jaiswal ◽  
Vikas Jhingran
Keyword(s):  
Fatigue Damage ◽  
Field Experiments ◽  
Higher Harmonics ◽  
Vortex Induced Vibration ◽  
Third Harmonic ◽  
The Third ◽  
Damage Rate ◽  
Surface Vessels ◽  
Vortex Shedding Frequency ◽  
First Time

This paper presents results from two field experiments using long flexible cylinders, suspended vertically from surface vessels. The experiments were designed to investigate vortex-induced vibration (VIV) at higher than tenth mode in uniform and sheared flows. The results of both experiments revealed significant vibration energy at the expected Strouhal frequency (referred to in this paper as the fundamental frequency) and also at two and three times the Strouhal frequency. Although higher harmonics have been reported before, this was the first time that the contribution to fatigue damage, resulting from the third harmonic, could be estimated with some certainty. This was enabled by the direct measurement of closely spaced strain gauges in one of the experiments. In some circumstances the largest RMS stress and fatigue damage due to VIV are caused by these higher harmonics. The total fatigue damage rate including the third harmonic is shown to be up to forty times greater than the damage rate due to the vibration at the fundamental vortex-shedding frequency alone. This dramatic increase in damage rate due to the third harmonic appears to be associated with a narrow range of reduced velocities in regions of the pipe associated with significant flow-induced excitation.

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