Recent advances in phosphine catalysis involving γ-substituted allenoates

2020 ◽  
Vol 56 (5) ◽  
pp. 680-694 ◽  
Author(s):  
Er-Qing Li ◽  
You Huang
Keyword(s):  
Feature Article ◽  
Recent Advances ◽  
Wide Range ◽  
Phosphine Catalysis

This feature article will describe the selected examples of organophosphine catalysis of γ-substituent allenoates with a wide range of electrophiles to give diverse annulations.

scholarly journals Recent Advances in Enzymatic and Non-Enzymatic Electrochemical Glucose Sensing

Sensors ◽  
2021 ◽  
Vol 21 (14) ◽  
pp. 4672
Author(s):  
Mohamed H. Hassan ◽  
Cian Vyas ◽  
Bruce Grieve ◽  
Paulo Bartolo
Keyword(s):  
Noble Metals ◽  
Direct Electrochemistry ◽  
Glucose Sensing ◽  
Glucose Sensors ◽  
Diabetic Patients ◽  
Past Century ◽  
Industrial Sectors ◽  
Recent Advances ◽  
Wide Range ◽  
Sensitivity And Selectivity

The detection of glucose is crucial in the management of diabetes and other medical conditions but also crucial in a wide range of industries such as food and beverages. The development of glucose sensors in the past century has allowed diabetic patients to effectively manage their disease and has saved lives. First-generation glucose sensors have considerable limitations in sensitivity and selectivity which has spurred the development of more advanced approaches for both the medical and industrial sectors. The wide range of application areas has resulted in a range of materials and fabrication techniques to produce novel glucose sensors that have higher sensitivity and selectivity, lower cost, and are simpler to use. A major focus has been on the development of enzymatic electrochemical sensors, typically using glucose oxidase. However, non-enzymatic approaches using direct electrochemistry of glucose on noble metals are now a viable approach in glucose biosensor design. This review discusses the mechanisms of electrochemical glucose sensing with a focus on the different generations of enzymatic-based sensors, their recent advances, and provides an overview of the next generation of non-enzymatic sensors. Advancements in manufacturing techniques and materials are key in propelling the field of glucose sensing, however, significant limitations remain which are highlighted in this review and requires addressing to obtain a more stable, sensitive, selective, cost efficient, and real-time glucose sensor.

Tuning metal–metal interactions for cooperative small molecule activation

2021 ◽  
Author(s):  
Qiuran Wang ◽  
Sam H. Brooks ◽  
Tianchang Liu ◽  
Neil C. Tomson
Keyword(s):  
Small Molecule ◽  
Small Molecule Activation ◽  
Feature Article ◽  
Metal Interactions ◽  
Recent Advances ◽  
Metal Metal

This Feature Article describes recent advances in the design of multinucleating ligands that support small molecule activation chemistry.

Recent advances in the design of inorganic and nano-clay particles for the treatment of brain disorders

2021 ◽  
Author(s):  
Francesca Persano ◽  
Svetlana Batasheva ◽  
Gölnur Fakhrullina ◽  
Giuseppe Gigli ◽  
Stefano Leporatti ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Silica Nanoparticles ◽  
Biomedical Applications ◽  
Inorganic Materials ◽  
Brain Disorders ◽  
Clay Particles ◽  
Recent Advances ◽  
Wide Range ◽  
Nano Clay

Inorganic materials, in particular nanoclays and silica nanoparticles, have attracted enormous attention due to their versatile and tuneable properties, making them ideal candidates for a wide range of biomedical applications, such as drug delivery.

N-Heterocyclic silylene in coinage metal chemistry: an account of recent advances

2021 ◽  
Author(s):  
Moushakhi Ghosh ◽  
Shabana Khan
Keyword(s):  
Exponential Growth ◽  
Coinage Metal ◽  
Feature Article ◽  
Metal Chemistry ◽  
Recent Advances ◽  
Recent Developments

This feature article intends to highlight and comprehensively summarize the recent developments in the field of silylene-coinage metal chemistry. Recent years have witnessed exponential growth in the utilization of N-heterocyclic...

scholarly journals Recent Advances in Nanovaccines Using Biomimetic Immunomodulatory Materials

Pharmaceutics ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 534 ◽  
Author(s):  
Vijayan ◽  
Mohapatra ◽  
Uthaman ◽  
Park
Keyword(s):  
Immune Responses ◽  
Targeted Delivery ◽  
Vaccine Development ◽  
Polymeric Nanoparticles ◽  
Vital Role ◽  
Effective Control ◽  
Therapeutic Vaccines ◽  
Hiv Therapy ◽  
Recent Advances ◽  
Wide Range

The development of vaccines plays a vital role in the effective control of several fatal diseases. However, effective prophylactic and therapeutic vaccines have yet to be developed for completely curing deadly diseases, such as cancer, malaria, HIV, and serious microbial infections. Thus, suitable vaccine candidates need to be designed to elicit appropriate immune responses. Nanotechnology has been found to play a unique role in the design of vaccines, providing them with enhanced specificity and potency. Nano-scaled materials, such as virus-like particles, liposomes, polymeric nanoparticles (NPs), and protein NPs, have received considerable attention over the past decade as potential carriers for the delivery of vaccine antigens and adjuvants, due to their beneficial advantages, like improved antigen stability, targeted delivery, and long-time release, for which antigens/adjuvants are either encapsulated within, or decorated on, the NP surface. Flexibility in the design of nanomedicine allows for the programming of immune responses, thereby addressing the many challenges encountered in vaccine development. Biomimetic NPs have emerged as innovative natural mimicking biosystems that can be used for a wide range of biomedical applications. In this review, we discuss the recent advances in biomimetic nanovaccines, and their use in anti-bacterial therapy, anti-HIV therapy, anti-malarial therapy, anti-melittin therapy, and anti-tumor immunity.

scholarly journals Origins and Evolution of the Global RNA Virome

mBio ◽  
2018 ◽  
Vol 9 (6) ◽  
Author(s):  
Yuri I. Wolf ◽  
Darius Kazlauskas ◽  
Jaime Iranzo ◽  
Adriana Lucía-Sanz ◽  
Jens H. Kuhn ◽  
...  
Keyword(s):  
Plant Pathogens ◽  
Rna Viruses ◽  
Rna Virus ◽  
Phylogenomic Analysis ◽  
Rna Helicases ◽  
Sequence Alignments ◽  
Recent Advances ◽  
Wide Range ◽  
Positive Sense ◽  
Dsrna Viruses

ABSTRACTViruses with RNA genomes dominate the eukaryotic virome, reaching enormous diversity in animals and plants. The recent advances of metaviromics prompted us to perform a detailed phylogenomic reconstruction of the evolution of the dramatically expanded global RNA virome. The only universal gene among RNA viruses is the gene encoding the RNA-dependent RNA polymerase (RdRp). We developed an iterative computational procedure that alternates the RdRp phylogenetic tree construction with refinement of the underlying multiple-sequence alignments. The resulting tree encompasses 4,617 RNA virus RdRps and consists of 5 major branches; 2 of the branches include positive-sense RNA viruses, 1 is a mix of positive-sense (+) RNA and double-stranded RNA (dsRNA) viruses, and 2 consist of dsRNA and negative-sense (−) RNA viruses, respectively. This tree topology implies that dsRNA viruses evolved from +RNA viruses on at least two independent occasions, whereas −RNA viruses evolved from dsRNA viruses. Reconstruction of RNA virus evolution using the RdRp tree as the scaffold suggests that the last common ancestors of the major branches of +RNA viruses encoded only the RdRp and a single jelly-roll capsid protein. Subsequent evolution involved independent capture of additional genes, in particular, those encoding distinct RNA helicases, enabling replication of larger RNA genomes and facilitating virus genome expression and virus-host interactions. Phylogenomic analysis reveals extensive gene module exchange among diverse viruses and horizontal virus transfer between distantly related hosts. Although the network of evolutionary relationships within the RNA virome is bound to further expand, the present results call for a thorough reevaluation of the RNA virus taxonomy.IMPORTANCEThe majority of the diverse viruses infecting eukaryotes have RNA genomes, including numerous human, animal, and plant pathogens. Recent advances of metagenomics have led to the discovery of many new groups of RNA viruses in a wide range of hosts. These findings enable a far more complete reconstruction of the evolution of RNA viruses than was attainable previously. This reconstruction reveals the relationships between different Baltimore classes of viruses and indicates extensive transfer of viruses between distantly related hosts, such as plants and animals. These results call for a major revision of the existing taxonomy of RNA viruses.

scholarly journals Recent Advances in Applications of Ceramic Nanofibers

2021 ◽  
Author(s):  
Nuray Kizildag
Keyword(s):  
High Surface ◽  
Sol Gel ◽  
High Surface Area ◽  
Ceramic Materials ◽  
Water Remediation ◽  
Mechanical And Thermal Properties ◽  
Chemical Erosion ◽  
Recent Advances ◽  
Wide Range ◽  
Ceramic Nanofibers

Ceramic materials are well known for their hardness, inertness, superior mechanical and thermal properties, resistance against chemical erosion and corrosion. Ceramic nanofibers were first manufactured through a combination of electrospinning with sol–gel method in 2002. The electrospun ceramic nanofibers display unprecedented properties such as high surface area, length, thermo-mechanical properties, and hierarchically porous structure which make them candidates for a wide range of applications such as tissue engineering, sensors, water remediation, energy storage, electromagnetic shielding, thermal insulation materials, etc. This chapter focuses on the most recent advances in the applications of ceramic nanofibers.

scholarly journals CubeSat Communications: Recent Advances and Future Challenges

2020 ◽  
Author(s):  
Nasir Saeed ◽  
Ahmed Elzanaty ◽  
Heba Almorad ◽  
Hayssam Dahrouj ◽  
Tareq Y. Al-Naffouri ◽  
...  
Keyword(s):  
Channel Modeling ◽  
Future Research ◽  
New Paradigm ◽  
Earth Remote Sensing ◽  
Research Directions ◽  
Space Industry ◽  
Recent Advances ◽  
Wide Range ◽  
Future Challenges ◽  
Future Research Directions

<pre><pre>Given the increasing number of space-related applications, research in the emerging space industry is becoming more and more attractive. One compelling area of current space research is the design of miniaturized satellites, known as CubeSats, which are enticing because of their numerous applications and low design-and-deployment cost. </pre><pre>The new paradigm of connected space through CubeSats makes possible a wide range of applications, such as Earth remote sensing, space exploration, and rural connectivity.</pre><pre>CubeSats further provide a complementary connectivity solution to the pervasive Internet of Things (IoT) networks, leading to a globally connected cyber-physical system.</pre><pre>This paper presents a holistic overview of various aspects of CubeSat missions and provides a thorough review of the topic from both academic and industrial perspectives.</pre><pre>We further present recent advances in the area of CubeSat communications, with an emphasis on constellation-and-coverage issues, channel modeling, modulation and coding, and networking.</pre><pre>Finally, we identify several future research directions for CubeSat communications, including Internet of space things, low-power long-range networks, and machine learning for CubeSat resource allocation.</pre></pre>

Humanoids can take Advantage of Crab-Walking Gaits

2015 ◽  
Vol 12 (01) ◽  
pp. 1550004
Author(s):  
Jonathan Spitz ◽  
Eric Sidorov ◽  
Miriam Zacksenhouse
Keyword(s):  
Humanoid Robots ◽  
Small Range ◽  
Rough Terrain ◽  
Recent Advances ◽  
Wide Range ◽  
Locomotion Pattern

Recent advances in control of humanoid robots have resulted in bipedal gaits that are dynamically stable on moderately rough terrain but are still limited to a small range of slopes. Humanoid robots, like humans, can take advantage of quadruped gaits to greatly extend this range. Cleverly designed gaits can provide robustness to rough terrain without requiring extensive feedback. In this paper, we present a robust crab-walking framework that includes forward and backward crawling patterns, rotation patterns, and sit-down and recovery sequences. The latter are activated autonomously once the robot detects that it tipped over. The performance and robustness of each locomotion pattern are investigated over a wide range of slopes. Crab-walking is shown to be especially adept at crawling forward on steep downward slopes (up to -54°) and crawling backward on steep upward slopes (up to 18°). Finally, we demonstrate the framework's autonomous capabilities by crossing the rough terrain in DARPA's virtual robotics challenge.

Hybrid Computational Intelligence and the Basic Concepts and Recent Advances

2018 ◽  
pp. 180-190
Author(s):  
Georgios Dounias
Keyword(s):  
Computational Intelligence ◽  
Intelligent Systems ◽  
Domain Knowledge ◽  
Hybrid Intelligent Systems ◽  
Complex Problems ◽  
Recent Advances ◽  
New Findings ◽  
Wide Range ◽  
Computational Intelligent ◽  
Computational Technology

In this paper computational intelligence and its major methodologies are introduced in the first place, and then hybrid intelligent systems are defined and the most popular hybrid intelligent approaches are discussed. The increased popularity of hybrid intelligent systems during the last decade, is the result of the extensive success of these systems in a wide range of real-world complex problems, but also has to do with the increased capabilities of computational technology. One of the reasons for this success has to do with the synergy derived by the computational intelligent components, such as machine learning, fuzzy logic, neural networks, genetic algorithms, or other intelligent algorithms and techniques. Each of the partial methodologies provides hybrid systems with complementary reasoning and searching methods that allow the use of domain knowledge and empirical data to solve complex problems. The paper includes recent advances and new findings in the area of hybrid computational intelligence.

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