scholarly journals Recent Advances in Enzymatic and Non-Enzymatic Electrochemical Glucose Sensing

Sensors ◽  
2021 ◽  
Vol 21 (14) ◽  
pp. 4672
Author(s):  
Mohamed H. Hassan ◽  
Cian Vyas ◽  
Bruce Grieve ◽  
Paulo Bartolo
Keyword(s):  
Noble Metals ◽  
Direct Electrochemistry ◽  
Glucose Sensing ◽  
Glucose Sensors ◽  
Diabetic Patients ◽  
Past Century ◽  
Industrial Sectors ◽  
Recent Advances ◽  
Wide Range ◽  
Sensitivity And Selectivity

The detection of glucose is crucial in the management of diabetes and other medical conditions but also crucial in a wide range of industries such as food and beverages. The development of glucose sensors in the past century has allowed diabetic patients to effectively manage their disease and has saved lives. First-generation glucose sensors have considerable limitations in sensitivity and selectivity which has spurred the development of more advanced approaches for both the medical and industrial sectors. The wide range of application areas has resulted in a range of materials and fabrication techniques to produce novel glucose sensors that have higher sensitivity and selectivity, lower cost, and are simpler to use. A major focus has been on the development of enzymatic electrochemical sensors, typically using glucose oxidase. However, non-enzymatic approaches using direct electrochemistry of glucose on noble metals are now a viable approach in glucose biosensor design. This review discusses the mechanisms of electrochemical glucose sensing with a focus on the different generations of enzymatic-based sensors, their recent advances, and provides an overview of the next generation of non-enzymatic sensors. Advancements in manufacturing techniques and materials are key in propelling the field of glucose sensing, however, significant limitations remain which are highlighted in this review and requires addressing to obtain a more stable, sensitive, selective, cost efficient, and real-time glucose sensor.

Recent advances in cation sensing using aggregation-induced emission

2021 ◽  
Author(s):  
Ming Hui Chua ◽  
Hui Zhou ◽  
Qiang Zhu ◽  
Ben Zhong Tang ◽  
Jian Wei Xu
Keyword(s):  
Metal Cations ◽  
Aggregation Induced Emission ◽  
Recent Advances ◽  
Wide Range ◽  
Sensitivity And Selectivity ◽  
Cation Sensing

This review summarizes recent advances in AIE-based chemosensors for the detection of a wide range of metal cations, outlining the various sensing mechanisms and sensing performances such as sensitivity and selectivity of AIE-based chemosensors. 

scholarly journals Recent Advances in Facile Synthesis of Bimetallic Nanostructures: An Overview

2014 ◽  
Vol 2014 ◽  
pp. 1-28 ◽  
Author(s):  
Arash Dehghan Banadaki ◽  
Amir Kajbafvala
Keyword(s):  
Noble Metals ◽  
Building Blocks ◽  
Magnetic Sensors ◽  
Effective Control ◽  
Synthesis Methods ◽  
Controllable Synthesis ◽  
Facile Synthesis ◽  
Recent Advances ◽  
Wide Range ◽  
Metal Nanomaterials

Nobel metal nanomaterials with interesting physical and chemical properties are ideal building blocks for engineering and tailoring nanoscale structures for specific technological applications. Bimetallic nanomaterials consisting of magnetic metals and noble metals have attracted much interest for their promising potentials in many fields including magnetic sensors, catalysts, optical detection, and biomedical applications. Particularly, effective control of the size, shape, architecture, and compositional microstructure of metal nanomaterials plays an important role in enhancing their functionality and application potentials, for example, in fuel cells, optical and biomedical sensing. This paper focuses on recent advances in controllable synthesis of bimetallic nanostructured materials. Recent contributions in controllable synthesis of bimetallic nanomaterials with different architectures including nanoparticles, nanowires, nanosheets, or nanotubes and their assemblies are presented in this paper. A wide range of facile synthesis methods are covered herein with high emphasis on wet chemical methods owing to their facility of use, efficacy, and smaller environmental footprint.

A “plasmonic cuvette”: dye chemistry coupled to plasmonic interferometry for glucose sensing

Nanophotonics ◽  
2014 ◽  
Vol 3 (3) ◽  
pp. 125-140 ◽  
Author(s):  
Vince S. Siu ◽  
Jing Feng ◽  
Patrick W. Flanigan ◽  
G. Tayhas R. Palmore ◽  
Domenico Pacifici
Keyword(s):  
Real Time ◽  
Biological Fluid ◽  
Artificial Saliva ◽  
High Sensitivity ◽  
Glucose Sensing ◽  
Intensity Change ◽  
Diabetic Patients ◽  
Measured Intensity ◽  
Glucose Assay ◽  
Sensitivity And Selectivity

AbstractA non-invasive method for the detection of glucose is sought by millions of diabetic patients to improve personal management of blood glucose over a lifetime. In this work, the synergistic advantage of combining plasmonic interferometry with an enzyme-driven dye assay yields an optical sensor capable of detecting glucose in saliva with high sensitivity and selectivity. The sensor, coined a “plasmonic cuvette,” is built around a nano-scale groove-slit-groove (GSG) plasmonic interferometer coupled to an Amplex–red/Glucose–oxidase/Glucose (AR/GOx/Glucose) assay. The proposed device is highly sensitive, with a measured intensity change of 1.7×105%/m (i.e., one order of magnitude more sensitive than without assay) and highly specific for glucose sensing in picoliter volumes, across the physiological range of glucose concentrations found in human saliva (20–240 μm). Real-time glucose monitoring in saliva is achieved by performing a detailed study of the underlying enzyme-driven reactions to determine and tune the effective rate constants in order to reduce the overall assay reaction time to ∼2 min. The results reported suggest that by opportunely choosing the appropriate dye chemistry, a plasmonic cuvette can be turned into a general, real-time sensing scheme for detection of any molecular target, with high sensitivity and selectivity, within extremely low volumes of biological fluid (down to femtoliters). Hereby, we present the results on glucose detection in artificial saliva as a notable and clinically relevant case study.

scholarly journals Recent Progress and Perspectives on Non-Invasive Glucose Sensors

Diabetology ◽  
2022 ◽  
Vol 3 (1) ◽  
pp. 56-71
Author(s):  
Nicholas B. Davison ◽  
Christopher J. Gaffney ◽  
Jemma G. Kerns ◽  
Qiandong D. Zhuang
Keyword(s):  
Optical Sensors ◽  
Technology Development ◽  
Optical Sensing ◽  
Glucose Monitoring ◽  
Glucose Sensing ◽  
Glucose Sensors ◽  
Monitoring Methods ◽  
Glucose Levels ◽  
Non Invasive ◽  
Wide Range

Self-monitoring of blood glucose forms an important part of the management of diabetes and the prevention of hyperglycaemia and hypoglycaemia. Current glucose monitoring methods either use needle-prick enzymatic glucose-meters or subcutaneous continuous glucose sensors (CGM) and thus, non-invasive glucose measurements could greatly improve the self-management of diabetes. A wide range of non-invasive sensing techniques have been reported, though achieving a level of precision comparable to invasive meters remains a challenge. Optical sensors, which utilise the interactions between glucose and light, offer the potential for non-invasive continuous sensing, allowing real-time monitoring of glucose levels, and a range of different optical sensing technologies have been proposed. These are primarily based upon optical absorption and scattering effects and include infrared spectroscopy, Raman spectroscopy and optical coherence tomography (OCT), with other optical techniques such as photoacoustic spectroscopy (PAS) and polarimetry also reported. This review aims to discuss the current progress behind the most reported optical glucose sensing methods, theory and current limitations of optical sensing methods and the future technology development required to achieve an accurate optical-based glucose monitoring device.

scholarly journals The Impact of Recent Developments in Electrochemical POC Sensor for Blood Sugar Care

2021 ◽  
Vol 9 ◽  
Author(s):  
Wei Li ◽  
Weixiang Luo ◽  
Mengyuan Li ◽  
Liyu Chen ◽  
Liyan Chen ◽  
...  
Keyword(s):  
First Generation ◽  
Electrochemical Sensors ◽  
Glucose Sensors ◽  
Future Research ◽  
Diabetic Patients ◽  
Glucose Testing ◽  
Recent Developments ◽  
Sensitivity And Selectivity ◽  
Diabetes Monitoring ◽  
The Impact

Rapid glucose testing is very important in the care of diabetes. Monitoring of blood glucose is the most critical indicator of disease control in diabetic patients. The invention and popularity of electrochemical sensors have made glucose detection fast and inexpensive. The first generation of glucose sensors had limitations in terms of sensitivity and selectivity. In order to overcome these problems, scientists have used a range of new materials to produce new glucose electrochemical sensors with higher sensitivity, selectivity and lower cost. A variety of different electrochemical sensors including enzymatic electrochemical sensors and enzyme-free electrochemical sensors have been extensively investigated. We discussed the development process of electrochemical glucose sensors in this review. We focused on describing the benefits of carbon materials in nanomaterials, specially graphene for sensors. In addition, we discussed the limitations of the sensors and challenges in future research.

scholarly journals Recent Advances in ZnO-Based Carbon Monoxide Sensors: Role of Doping

Sensors ◽  
2021 ◽  
Vol 21 (13) ◽  
pp. 4425
Author(s):  
Ana María Pineda-Reyes ◽  
María R. Herrera-Rivera ◽  
Hugo Rojas-Chávez ◽  
Heriberto Cruz-Martínez ◽  
Dora I. Medina
Keyword(s):  
Carbon Monoxide ◽  
High Performance ◽  
Gas Sensing ◽  
Experimental Studies ◽  
Electrical Performance ◽  
Long Term Stability ◽  
Sensing Applications ◽  
Recent Advances ◽  
Sensitivity And Selectivity ◽  
Doped Zno

Monitoring and detecting carbon monoxide (CO) are critical because this gas is toxic and harmful to the ecosystem. In this respect, designing high-performance gas sensors for CO detection is necessary. Zinc oxide-based materials are promising for use as CO sensors, owing to their good sensing response, electrical performance, cost-effectiveness, long-term stability, low power consumption, ease of manufacturing, chemical stability, and non-toxicity. Nevertheless, further progress in gas sensing requires improving the selectivity and sensitivity, and lowering the operating temperature. Recently, different strategies have been implemented to improve the sensitivity and selectivity of ZnO to CO, highlighting the doping of ZnO. Many studies concluded that doped ZnO demonstrates better sensing properties than those of undoped ZnO in detecting CO. Therefore, in this review, we analyze and discuss, in detail, the recent advances in doped ZnO for CO sensing applications. First, experimental studies on ZnO doped with transition metals, boron group elements, and alkaline earth metals as CO sensors are comprehensively reviewed. We then focused on analyzing theoretical and combined experimental–theoretical studies. Finally, we present the conclusions and some perspectives for future investigations in the context of advancements in CO sensing using doped ZnO, which include room-temperature gas sensing.

Recent advances in the design of inorganic and nano-clay particles for the treatment of brain disorders

2021 ◽  
Author(s):  
Francesca Persano ◽  
Svetlana Batasheva ◽  
Gölnur Fakhrullina ◽  
Giuseppe Gigli ◽  
Stefano Leporatti ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Silica Nanoparticles ◽  
Biomedical Applications ◽  
Inorganic Materials ◽  
Brain Disorders ◽  
Clay Particles ◽  
Recent Advances ◽  
Wide Range ◽  
Nano Clay

Inorganic materials, in particular nanoclays and silica nanoparticles, have attracted enormous attention due to their versatile and tuneable properties, making them ideal candidates for a wide range of biomedical applications, such as drug delivery.

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