Design and Function of Engineered Protein Nanocages as a Drug Delivery System for Targeting Pancreatic Cancer Cells via Neuropilin-1

2015 ◽  
Vol 12 (5) ◽  
pp. 1422-1430 ◽  
Author(s):  
Masaharu Murata ◽  
Sayoko Narahara ◽  
Takahito Kawano ◽  
Nobuhito Hamano ◽  
Jing Shu Piao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Drug Delivery System ◽  
Delivery System ◽  
Pancreatic Cancer Cells ◽  
Neuropilin 1 ◽  
And Function

EVALUATION OF THE UPTAKE OF CDDP-CONTAINING POLYMERIC MICELLES IN SINGLE PANCREATIC CANCER CELLS

2010 ◽  
Vol 20 (01n02) ◽  
pp. 37-43 ◽  
Author(s):  
K. MIZUNO ◽  
M. UESAKA ◽  
S. MATSUYAMA ◽  
Y. ITO ◽  
K. ISHII ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Anticancer Drugs ◽  
Delivery System ◽  
Polymeric Micelles ◽  
Human Pancreatic Cancer ◽  
Accumulation Rates ◽  
Pancreatic Cancer Cells ◽  
Kinetics Of

Highly functionalized drugs delivered via a drug delivery system are expected to have less side effects and higher accumulation rates compared to conventional anticancer drugs. An understanding of the kinetics of drugs contained within a delivery system is necessary to obtain the maximum therapeutic effect. We performed micro-elemental analysis of human pancreatic cancer cells treated with cis-diamminedichloroplatinum(II) (CDDP)-containing polymeric micelles. The results showed that the platinum signals were distributed inside the cellular nuclei and the cytoplasm indicating that CDDP was delivered into the cells. The results from this study will be useful for designing an optimum carrier for platinum-containing anticancer drugs.

scholarly journals pH and redox dual-sensitive drug delivery system constructed based on fluorescent carbon dots

RSC Advances ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 2656-2663
Author(s):  
Boye Zhang ◽  
Qianqian Duan ◽  
Yi Li ◽  
Jianming Wang ◽  
Wendong Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Cancer Cells ◽  
Fluorescence Imaging ◽  
Drug Delivery System ◽  
Delivery System ◽  
Carbon Dots ◽  
Ph Responsive ◽  
Charge Reversal ◽  
Fluorescent Carbon Dots

The system is pH-responsive and redox-controlled release. And the charge reversal and size transitions of the system can enhance the targeted ability. Moreover, the system can recognize the cancer cells by the fluorescence imaging.

An Acid-Triggered Degradable and Fluorescent Nanoscale Drug Delivery System with Enhanced Cytotoxicity to Cancer Cells

2015 ◽  
Vol 16 (8) ◽  
pp. 2444-2454 ◽  
Author(s):  
Jinxia An ◽  
Xiaomei Dai ◽  
Zhongming Wu ◽  
Yu Zhao ◽  
Zhentan Lu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Drug Delivery System ◽  
Delivery System

scholarly journals Self-assembled pH-responsive supramolecular hydrogel for hydrophobic drug delivery

RSC Advances ◽  
2018 ◽  
Vol 8 (55) ◽  
pp. 31581-31587 ◽  
Author(s):  
Lin Wang ◽  
Xuefeng Shi ◽  
Jian Zhang ◽  
Yuejun Zhu ◽  
Jinben Wang
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Drug Delivery System ◽  
Delivery System ◽  
Hydrophobic Drug ◽  
Ph Responsive ◽  
Supramolecular Hydrogel ◽  
Self Assembled

Supramolecular hydrogel, AGC16/NTS, was used to encapsulate hydrophobic drug curcumin (Cur), constructing a pH-responsive drug delivery system; the uptake of released Cur by cancer cells also occurred.

Pseudo-branched polyester copolymer: an efficient drug delivery system to treat cancer

2020 ◽  
Vol 8 (6) ◽  
pp. 1592-1603
Author(s):  
Zachary Shaw ◽  
Arth Patel ◽  
Thai Butcher ◽  
Tuhina Banerjee ◽  
Ren Bean ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Drug Delivery System ◽  
Delivery System ◽  
Diagnosis And Treatment ◽  
Therapeutic Drug

New aliphatic pseudo-branched polyester copolymers are synthesized from diethylmalonate. The formulated nanomedicine successfully encapsulates therapeutic drug in higher dosage and deliver specifically to cancer cells for diagnosis and treatment.

Using Magnetic and Photic Stimuli-Responsive Liposomes to Serve Up Chemotherapy Drugs to Cancer Cells

2020 ◽  
Vol 16 (6) ◽  
pp. 867-875
Author(s):  
Junlin Li ◽  
Lingyun Hao ◽  
Xiaojuan Zhang ◽  
Qing Lin ◽  
Dong Liang
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Cancer Cells ◽  
Drug Delivery System ◽  
Delivery System ◽  
Uv Light ◽  
Atomic Ratio ◽  
Solution Temperature ◽  
Photothermal Effect ◽  
Chemotherapy Drugs

Liposome is a traditional drug-delivery system and most novel studies have focused on its drug release function. In this paper, a new drug-delivery system based on liposomes was prepared, which contains hydrophobic FeAg alloy nanoparticles (FeAgNPs) in their lipid bilayer and berberine as test drug in their middle water phase. The size of AgFe-Ls was about 200 nm, the encapsulation efficiency of drugs was 35% and the lower critical solution temperature (LCST) of AgFe-Ls was about 41.96 °C. FeAgNPs in the AgFe-Ls had a 1:1 iron-to-silver atomic ratio with both optical and superparamagnetic properties. The photothermal effect and magnetocaloric effect of FeAgNPs could serve up both photo-stimulated and magnetic- stimulated drug release to liposomes. Release experiments results showed that AgFe-Ls could easily release berberine when stimulated by UV light (45% drug release at 20 min) or alternating current electromagnetic field (AMF) (80% drug release at 4 h). AgFe-Ls with both photo-controlled and magnetic-controlled drug release functions are promising to serve up chemotherapy drugs to cancer cells.

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