A biotinylated ruthenium(ii) photosensitizer for tumor-targeted two-photon photodynamic therapy

2019 ◽  
Vol 55 (73) ◽  
pp. 10972-10975 ◽  
Author(s):  
Jia Li ◽  
Leli Zeng ◽  
Kai Xiong ◽  
Thomas W. Rees ◽  
Chengzhi Jin ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Cancer Cells ◽  
Cisplatin Resistance ◽  
Two Photon ◽  
Target Cancer

A biotinylated ruthenium(ii) two-photon photosensitizer was developed to selectively target cancer cells and overcome cisplatin resistance by the production of high levels of singlet oxygen.

An AceDAN–porphyrin(Zn) dyad for fluorescence imaging and photodynamic therapy via two-photon excited FRET

2018 ◽  
Vol 5 (12) ◽  
pp. 3061-3066 ◽  
Author(s):  
Mengliang Zhu ◽  
Chaorui Su ◽  
Peipei Xing ◽  
Yabin Zhou ◽  
Lei Gong ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Cancer Cells ◽  
Fluorescence Imaging ◽  
Red Emission ◽  
Two Photon

A FRET based AceDAN–porphyrin(Zn) dyad was designed to generate red emission and singlet oxygen (1O2) simultaneously, which were utilized successfully for two-photon excited fluorescence imaging and PDT of cancer cells.

scholarly journals Highly efficient singlet oxygen generation, two-photon photodynamic therapy and melanoma ablation by rationally designed mitochondria-specific near-infrared AIEgens

2020 ◽  
Vol 11 (9) ◽  
pp. 2494-2503 ◽  
Author(s):  
Zheng Zheng ◽  
Haixiang Liu ◽  
Shaodong Zhai ◽  
Haoke Zhang ◽  
Guogang Shan ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Near Infrared ◽  
Molecular Engineering ◽  
Photon Absorption ◽  
Oxygen Generation ◽  
Two Photon Absorption ◽  
Two Photon ◽  
Singlet Oxygen Generation ◽  
Highly Efficient

Mitochondria-targeted photosensitizers with highly efficient singlet oxygen generation, bright near-infrared AIE and good two-photon absorption are obtained through ingenious molecular engineering for cancer cell-selective photodynamic therapy.

scholarly journals Biocompatible conjugated fluorenylporphyrins for two-photon photodynamic therapy and fluorescence imaging

2019 ◽  
Vol 55 (81) ◽  
pp. 12231-12234 ◽  
Author(s):  
Limiao Shi ◽  
Christophe Nguyen ◽  
Morgane Daurat ◽  
Abdelhamid Chiheb Dhieb ◽  
Wajda Smirani ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Fluorescence Imaging ◽  
Breast Cancer Cells ◽  
Two Photon ◽  
Theranostic Applications

Three new biocompatible porphyrin-based oxygen photosensitisers were tested in vitro on breast cancer cells via 2P-PDT: one of them, 66 times more active than H2TPP, gave quite promising results for theranostic applications.

Absorption-dependent generation of singlet oxygen from gold bipyramids excited under low power density

RSC Advances ◽  
2015 ◽  
Vol 5 (100) ◽  
pp. 81897-81904 ◽  
Author(s):  
Junliang Lv ◽  
Xin Zhang ◽  
Nana Li ◽  
Baoju Wang ◽  
Sailing He
Keyword(s):  
Photodynamic Therapy ◽  
Low Power ◽  
Singlet Oxygen ◽  
Cancer Cells ◽  
Power Density ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
Photodynamic Therapy Of Cancer

Gold bipyramid-mediated singlet oxygen generation for photodynamic therapy of cancer cells in the optical biological window.

scholarly journals Metal Complexes for Two-Photon Photodynamic Therapy: A Cyclometallated Iridium Complex Induces Two-Photon Photosensitization of Cancer Cells under Near-IR Light

2016 ◽  
Vol 23 (2) ◽  
pp. 234-238 ◽  
Author(s):  
Luke K. McKenzie ◽  
Igor V. Sazanovich ◽  
Elizabeth Baggaley ◽  
Mickaële Bonneau ◽  
Véronique Guerchais ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Metal Complexes ◽  
Cancer Cells ◽  
Iridium Complex ◽  
Two Photon ◽  
Near Ir ◽  
Ir Light

scholarly journals A self-reporting AIE probe with a built-in singlet oxygen sensor for targeted photodynamic ablation of cancer cells

2016 ◽  
Vol 7 (3) ◽  
pp. 1862-1866 ◽  
Author(s):  
Youyong Yuan ◽  
Chong-Jing Zhang ◽  
Shidang Xu ◽  
Bin Liu
Keyword(s):  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Cancer Cells ◽  
Oxygen Sensor ◽  
Aggregation Induced Emission ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation

A probe for the in situ monitoring of singlet oxygen generation during targeted theranostic photodynamic therapy is developed based on a photosensitizer with aggregation-induced emission (AIE) characteristics and conjugated to a fluorogenic rhodol dye via a singlet oxygen cleavable linker.

Diketopyrrolopyrrole-Porphyrin Conjugates with High Two-Photon Absorption and Singlet Oxygen Generation for Two-Photon Photodynamic Therapy

2014 ◽  
Vol 127 (1) ◽  
pp. 171-175 ◽  
Author(s):  
Julie Schmitt ◽  
Valérie Heitz ◽  
Angélique Sour ◽  
Frédéric Bolze ◽  
Hussein Ftouni ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Photon Absorption ◽  
Oxygen Generation ◽  
Two Photon Absorption ◽  
Two Photon ◽  
Singlet Oxygen Generation

Fluorescent periodic mesoporous organosilica nanoparticles dual-functionalized via click chemistry for two-photon photodynamic therapy in cells

2016 ◽  
Vol 4 (33) ◽  
pp. 5567-5574 ◽  
Author(s):  
Jonas G. Croissant ◽  
Sébastien Picard ◽  
Dina Aggad ◽  
Maxime Klausen ◽  
Chiara Mauriello Jimenez ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Photodynamic Therapy ◽  
Click Chemistry ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Periodic Mesoporous Organosilica ◽  
Two Photon ◽  
Mesoporous Organosilica ◽  
Photon Imaging ◽  
In Cells

The synthesis of ethenylene-based periodic mesoporous organosilica nanoparticles for two-photon imaging and photodynamic therapy of breast cancer cells is described.

Emerging Therapeutic Targets in Oncologic Photodynamic Therapy

2019 ◽  
Vol 24 (44) ◽  
pp. 5268-5295 ◽  
Author(s):  
Gina Manda ◽  
Mihail E. Hinescu ◽  
Ionela V. Neagoe ◽  
Luis F.V. Ferreira ◽  
Rica Boscencu ◽  
...  
Keyword(s):  
Cell Death ◽  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Cancer Cells ◽  
Cancer Progression ◽  
Molecular Mechanisms ◽  
Therapeutic Targets ◽  
Molecular Networks ◽  
Systems Medicine ◽  
Therapeutic Tools

Background:Reactive oxygen species sustain tumorigenesis and cancer progression through deregulated redox signalling which also sensitizes cancer cells to therapy. Photodynamic therapy (PDT) is a promising anti-cancer therapy based on a provoked singlet oxygen burst, exhibiting a better toxicological profile than chemo- and radiotherapy. Important gaps in the knowledge on underlining molecular mechanisms impede on its translation towards clinical applications.Aims and Methods:The main objective of this review is to critically analyse the knowledge lately gained on therapeutic targets related to redox and inflammatory networks underlining PDT and its outcome in terms of cell death and resistance to therapy. Emerging therapeutic targets and pharmaceutical tools will be documented based on the identified molecular background of PDT.Results:Cellular responses and molecular networks in cancer cells exposed to the PDT-triggered singlet oxygen burst and the associated stresses are analysed using a systems medicine approach, addressing both cell death and repair mechanisms. In the context of immunogenic cell death, therapeutic tools for boosting anti-tumor immunity will be outlined. Finally, the transcription factor NRF2, which is a major coordinator of cytoprotective responses, is presented as a promising pharmacologic target for developing co-therapies designed to increase PDT efficacy.Conclusion:There is an urgent need to perform in-depth molecular investigations in the field of PDT and to correlate them with clinical data through a systems medicine approach for highlighting the complex biological signature of PDT. This will definitely guide translation of PDT to clinic and the development of new therapeutic strategies aimed at improving PDT.

scholarly journals A multifunctional nanoprobe for targeting tumors and mitochondria with singlet oxygen generation and monitoring mitochondrion pH changes in cancer cells by ratiometric fluorescence imaging

2020 ◽  
Vol 11 (14) ◽  
pp. 3636-3643 ◽  
Author(s):  
Jingjin Zhao ◽  
Mengbing Zou ◽  
Mengjiao Huang ◽  
Liangliang Zhang ◽  
Keqin Yang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Cancer Cells ◽  
Fluorescence Imaging ◽  
Ratiometric Fluorescence ◽  
Oxygen Generation ◽  
Ph Changes ◽  
Singlet Oxygen Generation ◽  
Multifunctional Nanoprobe

A multifunctional nanoprobe with singlet oxygen generation that can target tumors and mitochondria was developed for photodynamic therapy of tumors and monitoring mitochondrion pH changes in cancer cells by ratiometric fluorescence imaging.

Sign in / Sign up

Export Citation Format

Share Document