Chirality transfer based on dynamic covalent chemistry: from small chiral molecules to supramolecules

2019 ◽  
Vol 55 (66) ◽  
pp. 9861-9864 ◽  
Author(s):  
Panpan Sun ◽  
Shujing Ren ◽  
Aoli Wu ◽  
Na Sun ◽  
Lijuan Shi ◽  
...  
Keyword(s):  
Small Molecule ◽  
Chiral Molecules ◽  
Chirality Transfer ◽  
Dynamic Covalent Chemistry

Chirality transfer from small molecule to supramolecule was successfully achieved via regulation of dynamic covalent chemistry.

Dynamic Covalent Chemistry within Biphenyl Scaffolds: Effects from Endocyclic to Exocyclic Sulfonamides

Synlett ◽  
2018 ◽  
Vol 29 (16) ◽  
pp. 2131-2136 ◽  
Author(s):  
Lei You ◽  
Cailing Ni ◽  
Meng Wang
Keyword(s):  
Dual Reactivity ◽  
Chirality Transfer ◽  
Dynamic Covalent Chemistry ◽  
Chiral Induction ◽  
Helical Twist ◽  
History Of ◽  
The Rich ◽  
Rich History ◽  
Chirality Induction ◽  
New Strategies

There is unabated interest in developing new strategies for the control of atropisomers despite the rich history of atropisomerism. We recently introduced dynamic covalent reactions (DCRs) within biphenyl skeletons for the incorporation and chirality recognition of multiple classes of mononucleophiles. To expand the scope of this strategy, the sulfonamide unit was switched from an endocyclic to an exocyclic position, and the influence of the resulting DCRs on chiral induction was investigated. The intramolecular equilibrium between the open aldehyde and its cyclic hemiaminal favored the ring form, and excellent chirality transfer from the hemiaminal stereocenter to the helical twist of the biphenyl was revealed. The modulation of unique dual reactivity then allowed the realization of DCRs of a diverse set of amines and alcohols. The degree of chirality induction was further explored by employing chiral substrates, affording significant circular dichroism signals.

Photoluminescence spectral broadening, chirality transfer and amplification of chiral perovskite materials (R-X-p-mBZA)2PbBr4 (X = H, F, Cl, Br) regulated by van der Waals and halogen atoms interactions

2020 ◽  
Vol 22 (30) ◽  
pp. 17299-17305
Author(s):  
Chenyang Zhou ◽  
Ya Chu ◽  
Linlin Ma ◽  
Yingqian Zhong ◽  
Chao Wang ◽  
...  
Keyword(s):  
Van Der Waals ◽  
Chiral Molecules ◽  
Spectral Broadening ◽  
Chirality Transfer ◽  
Inorganic Hybrid ◽  
Halogen Atoms ◽  
Perovskite Materials ◽  
A Site

We introduced halogen-substituted chiral molecules as A-site cations to synthesize a series of novel organic–inorganic hybrid 2D chiral perovskite materials (R-X-p-mBZA)2PbBr4 (X = H, F, Cl, Br; p: para-position; mBZA = α-methylbenzylamine).

A privileged ternary blend enabling non-fullerene organic photovoltaics with over 14% efficiency

2020 ◽  
Vol 8 (43) ◽  
pp. 15135-15141
Author(s):  
Jing Yan ◽  
Yuan-Qiu-Qiang Yi ◽  
Jianqi Zhang ◽  
Huanran Feng ◽  
Yanfeng Ma ◽  
...  
Keyword(s):  
Small Molecule ◽  
Organic Photovoltaics ◽  
Power Conversion ◽  
Ternary Blend ◽  
Conversion Efficiencies

Two non-fullerene small molecule acceptors, NT-4F and NT-4Cl, were designed and synthesized. Power conversion efficiencies of 11.44% and 14.55% were achieved for NT-4Cl-based binary and ternary devices, respectively.

The small-molecule antibiotics pipeline: 2014–2018

2019 ◽  
Vol 18 (10) ◽  
pp. 739-739 ◽  
Author(s):  
Cara Lepore ◽  
Lynn Silver ◽  
Ursula Theuretzbacher ◽  
Joe Thomas ◽  
David Visi
Keyword(s):  
Small Molecule

Anisotropic forces in small molecule crystals

1985 ◽  
Vol 82 ◽  
pp. 91-97 ◽  
Author(s):  
H. Bonadeo ◽  
E. Burgos
Keyword(s):  
Small Molecule

P157 FBXO3-FBXL2 AXIS MODULATORS AS A NOVEL CLASS OF ORAL SMALL MOLECULE COMPOUNDS FOR THE TREATMENT OF CROHN’S DISEASE

2020 ◽  
Vol 158 (3) ◽  
pp. S9-S10
Author(s):  
Franca Angeli ◽  
Russell Wyborski ◽  
Bill Chen ◽  
Rama Mallampalli ◽  
Michael Lark
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Small Molecule

Targeting the p53 tumor suppressor activity in glioblastomas using small molecule MDM2-inhibitor

2011 ◽  
Vol 42 (01) ◽  
Author(s):  
P. Monfared ◽  
T. Viel ◽  
G. Schneider ◽  
Y. Waerzeggers ◽  
S. Rapic ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Small Molecule ◽  
Suppressor Activity ◽  
P53 Tumor Suppressor ◽  
Tumor Suppressor Activity ◽  
Mdm2 Inhibitor
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