Ultrasensitive and simultaneous determination of RNA modified nucleotides by sheathless interfaced capillary electrophoresis–tandem mass spectrometry

2019 ◽  
Vol 55 (53) ◽  
pp. 7595-7598 ◽  
Author(s):  
Yue Yu ◽  
Si-Hao Zhu ◽  
Fang Yuan ◽  
Xiao-Hui Zhang ◽  
Yan-Ye Lu ◽  
...  

A label-free ultrasensitive method was established for the simultaneous determination of RNA modified nucleotides based on a sheathless capillary electrophoresis–tandem mass spectrometry system and successfully applied to investigate the effects of exposure to nickel ions on RNA epigenetics.

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