1H NMR determination of 1,3-dicyclohexylurea, glutaric acid and triethylamine in medical four-arm poly(ethylene glycol)-N-hydroxysuccinimide-glutarate for better quality control

2019 ◽  
Vol 11 (48) ◽  
pp. 6176-6183 ◽  
Author(s):  
Fei-Fei Li ◽  
Hui-Xiang Liu ◽  
Yan-Li Zhang ◽  
Shu-Qi Wang
Keyword(s):  
Quality Control ◽  
Nmr Spectroscopy ◽  
Ethylene Glycol ◽  
Simultaneous Determination ◽  
Glutaric Acid ◽  
Polymer Materials ◽  
Poly Ethylene Glycol ◽  
H Nmr ◽  
Poly Ethylene

Simultaneous determination of 1,3-dicyclohexylurea, glutaric acid and triethylamine by 1H NMR spectroscopy for established quality control standards for residues in polymer materials.

Synthesis of Poly(ethylene glycol) Derivatives

2013 ◽  
Vol 750-752 ◽  
pp. 1674-1677
Author(s):  
Hai Yun Chen ◽  
Yu Kai Shan ◽  
Yu Yue Qin ◽  
Guo Xian Zhou ◽  
Ming Long Yuan
Keyword(s):  
Nmr Spectroscopy ◽  
Ethylene Glycol ◽  
Biologically Active ◽  
Poly Ethylene Glycol ◽  
H Nmr ◽  
End Groups ◽  
Poly Ethylene ◽  
Ethylene Glycol Derivatives

To expand the extent of conjugation with biologically active molecules (biopolymers, peptides, drugs, etc.) and biomaterial substrates, we synthesized a serial of poly (ethy1ene glycol) (PEG) derivatives (PEG-2000-NH2, MPEG-1200-NH2, and APEG-1200-NH2) in three efficient steps. The end groups were characterized by 1H NMR spectroscopy.

scholarly journals A Non-Cytotoxic Resin for Micro-Stereolithography for Cell Cultures of HUVECs

Micromachines ◽  
2020 ◽  
Vol 11 (3) ◽  
pp. 246 ◽  
Author(s):  
Max Männel ◽  
Carolin Fischer ◽  
Julian Thiele
Keyword(s):  
Cell Culture ◽  
Ethylene Glycol ◽  
Umbilical Vein ◽  
Polymer Materials ◽  
Poly Ethylene Glycol ◽  
Glycol Diacrylate ◽  
3D Printed ◽  
Poly Ethylene ◽  
The Impact

Three-dimensional (3D) printing of microfluidic devices continuously replaces conventional fabrication methods. A versatile tool for achieving microscopic feature sizes and short process times is micro-stereolithography (µSL). However, common resins for µSL lack biocompatibility and are cytotoxic. This work focuses on developing new photo-curable resins as a basis for µSL fabrication of polymer materials and surfaces for cell culture. Different acrylate- and methacrylate-based compositions are screened for material characteristics including wettability, surface roughness, and swelling behavior. For further understanding, the impact of photo-absorber and photo-initiator on the cytotoxicity of 3D-printed substrates is studied. Cell culture experiments with human umbilical vein endothelial cells (HUVECs) in standard polystyrene vessels are compared to 3D-printed parts made from our library of homemade resins. Among these, after optimizing material composition and post-processing, we identify selected mixtures of poly(ethylene glycol) diacrylate (PEGDA) and poly(ethylene glycol) methyl ethyl methacrylate (PEGMEMA) as most suitable to allow for fabricating cell culture platforms that retain both the viability and proliferation of HUVECs. Next, our PEGDA/PEGMEMA resins will be further optimized regarding minimal feature size and cell adhesion to fabricate microscopic (microfluidic) cell culture platforms, e.g., for studying vascularization of HUVECs in vitro.

scholarly journals Synthesis of Mono- and Dithiols of Tetraethylene Glycol and Poly(ethylene glycol)s via Enzyme Catalysis

Catalysts ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 228 ◽  
Author(s):  
Prajakatta Mulay ◽  
Gayatri Shrikhande ◽  
Judit Puskas
Keyword(s):  
Nmr Spectroscopy ◽  
Ethylene Glycol ◽  
1H Nmr ◽  
Enzyme Catalysis ◽  
1H Nmr Spectroscopy ◽  
13C Nmr Spectroscopy ◽  
Tetraethylene Glycol ◽  
Candida Antarctica Lipase ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

This paper investigates the transesterification of methyl 3-mercaptopropionate (MP-SH) with tetraethylene glycol (TEG) and poly(ethylene glycol)s (PEG)s catalyzed by Candida antarctica Lipase B (CALB) without the use of solvent (in bulk). The progress of the reactions was monitored by 1H-NMR spectroscopy. We found that the reactions proceeded in a step-wise manner, first producing monothiols. TEG-monothiol was obtained in 15 min, while conversion to dithiol took 8 h. Monothiols from PEGs with Mn = 1000 and 2050 g/mol were obtained in 8 and 16 h, respectively. MALDI-ToF mass spectrometry verified the absence of dithiols. The synthesis of dithiols required additional fresh CALB and MP-SH. The structure of the products was confirmed by 1H-NMR and 13C-NMR spectroscopy. Enzyme catalysis was found to be a powerful tool to effectively synthesize thiol-functionalized TEGs and PEGs.

Photopolymerization of poly(ethylene glycol) dimethacrylates: The influence of ionic liquids on the formulation and the properties of the resultant polymer materials

2010 ◽  
Vol 48 (11) ◽  
pp. 2388-2409 ◽  
Author(s):  
Sergey A. Chesnokov ◽  
Marya Yu. Zakharina ◽  
Alexander S. Shaplov ◽  
Elena I. Lozinskaya ◽  
Inna A. Malyshkina ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Ethylene Glycol ◽  
Polymer Materials ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene
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