A novel water-soluble fluorescent probe with ultra-sensitivity over a wider pH range and its application for differentiating cancer cells from normal cells

The Analyst ◽  
2019 ◽  
Vol 144 (23) ◽  
pp. 6975-6980 ◽  
Author(s):  
Zilu Li ◽  
Chen Yu ◽  
Yanan Chen ◽  
Zihan Zhuang ◽  
Bin Tian ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Fluorescent Probe ◽  
Water Soluble ◽  
Normal Cells ◽  
Ph Range

A water-soluble fluorescent probe with ultra-sensitivity over a wider pH range was developed to differentiate cancer cells from normal cells.

A fluorescent probe for simultaneously sensing NTR and hNQO1 and distinguishing cancer cells

2019 ◽  
Vol 7 (43) ◽  
pp. 6822-6827 ◽  
Author(s):  
Fanpeng Kong ◽  
Ying Li ◽  
Chao Yang ◽  
Xiao Li ◽  
Junlin Wu ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Fluorescent Probe ◽  
Normal Cells

A dual-enzyme-responsive probe, CNN, was rationally designed and synthesized for differentiating cancer cells from normal cells owing to the existence of relatively high endogenous levels of both biomarkers in cancer cells.

scholarly journals Fluorescent probe based on N-doped carbon dots for the detection of intracellular pH and glutathione

RSC Advances ◽  
2020 ◽  
Vol 10 (56) ◽  
pp. 33635-33641
Author(s):  
Meihua Lin ◽  
Xin Ma ◽  
Shijun Lin ◽  
Xiaojin Zhang ◽  
Yu Dai ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Fluorescent Probe ◽  
Intracellular Ph ◽  
Carbon Dots ◽  
Fluorescence Probe ◽  
Normal Cells ◽  
Doped Carbon Dots

N-doped carbon dots used as a fluorescence probe can distinguish cancer cells from normal cells by pH and evaluate intracellular GSH.

A novel highly sensitive fluorescent probe for bioimaging biothiols and its applications in distinguishing cancer cells from normal cells

The Analyst ◽  
2019 ◽  
Vol 144 (23) ◽  
pp. 7010-7016 ◽  
Author(s):  
Hanchuang Zhu ◽  
Hanming Zhang ◽  
Changxu Liang ◽  
Caiyun Liu ◽  
Pan Jia ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Fluorescent Probe ◽  
Normal Cells ◽  
Highly Sensitive

The efficient discrimination of cancer cells from normal cells was achieved with a novel highly sensitive biothiol-specific fluorescent probe.

A ‘turn-on’ fluorescent probe for lysosomal phosphatase: a comparative study for labeling of cancer cells

2018 ◽  
Vol 6 (27) ◽  
pp. 4514-4521 ◽  
Author(s):  
Arup Podder ◽  
Sudipta Senapati ◽  
Pralay Maiti ◽  
Devaraj Kamalraj ◽  
Syed S Jaffer ◽  
...  
Keyword(s):  
Comparative Study ◽  
Cancer Cells ◽  
Fluorescent Probe ◽  
Normal Cells ◽  
Turn On

A turn-on fluorescent probe (LP1) discriminates cancer cells from normal cells based on expression of phosphatase in lysosomes.

A ratiometric fluorescent probe based on AIEgen for detecting HClO in living cells

2020 ◽  
Vol 56 (93) ◽  
pp. 14613-14616
Author(s):  
Weijie Zhang ◽  
He Wang ◽  
Feng Li ◽  
Yuncong Chen ◽  
Ryan T. K. Kwok ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Fluorescent Probe ◽  
High Performance ◽  
Living Cells ◽  
Normal Cells ◽  
Ratiometric Fluorescent Probe

A high performance ratiometric fluorescent probe, namely TPE-RNS, has been developed for detecting exogenous and endogenous HClO/ClO− in living cells and discriminating cancer cells from normal cells.

Amphiphilic fluorescent probe self-encored in plasma to detect pH fluctuations in cancer cell membranes

2021 ◽  
Author(s):  
Arup Podder ◽  
Manu M. Joseph ◽  
Shayeri Biswas ◽  
Sanjib Samanta ◽  
Kaustabh K. Maiti ◽  
...  
Keyword(s):  
Cell Surface ◽  
Cancer Cells ◽  
Fluorescent Probe ◽  
Cancer Cell ◽  
Cell Membranes ◽  
Normal Cells ◽  
Turn On ◽  
Ph Fluctuations

Newly developed an amphiphilic “turn-on” fluorescent probe (P1CS) enables to distinguish of cancer cells from normal cells through mapping of pH fluctuations in cell-surface.

An AIE-based self-assembled fluorescent probe for COX-2 imaging

2019 ◽  
Vol 43 (20) ◽  
pp. 7874-7880 ◽  
Author(s):  
Xiaozheng Cao ◽  
Tang Gao ◽  
Jie Dong ◽  
Xinchen Jiang ◽  
Hui Zou ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Fluorescent Probe ◽  
Cyclooxygenase 2 ◽  
Normal Cells ◽  
Cox 2 ◽  
Self Assembled

The first AIE-based fluorescent probe TPI-IMC was developed for imaging of cyclooxygenase-2 (COX-2) in normal cells and cancer cells.

scholarly journals Synthesis and Characterization of FITC Labelled Ruthenium Dendrimer as a Prospective Anticancer Drug

Biomolecules ◽  
2019 ◽  
Vol 9 (9) ◽  
pp. 411 ◽  
Author(s):  
Sylwia Michlewska ◽  
Małgorzata Kubczak ◽  
Marta Maroto-Díaz ◽  
Natalia Sanz del Olmo ◽  
Paula Ortega ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Fluorescent Probe ◽  
Chemical Sensors ◽  
Cytotoxic Effect ◽  
Fluorescein Isothiocyanate ◽  
Synthesis And Characterization ◽  
Normal Cells ◽  
Anticancer Effects ◽  
Porphyrin Core

Metallodendrimers—dendrimers with included metals—are widely investigated as biocompatible equivalents to metal nanoparticles. Applications can be expected in the fields of catalysis, as chemical sensors in molecular recognition and as anticancer drugs. Metallodendrimers can also mimic certain biomolecules, for example, haemoprotein in the case of using a dendrimer with a porphyrin core. In previous papers, we showed the promising anticancer effects of carbosilane ruthenium dendrimers. The present paper is devoted to studying biocompatibility and the cytotoxic effect on normal and cancer cells of carbosilane ruthenium dendrimers labelled with fluorescent probe fluorescein isothiocyanate (FITC). The addition of fluorescent probe allowed tracking the metallodendrimer in both normal and cancer cells. It was found that carbosilane ruthenium dendrimer labelled with FITC in concentration up to 10 µmol/L was more cytotoxic for cancer cells than for normal cells. Thus, FITC labelled carbosilane ruthenium dendrimer is a good candidate for diagnostic imaging and studying anticancer effects of metallodendrimers in cancer therapy.

A two-photon fluorescent probe for sensitive detection and imaging of γ-glutamyl transpeptidase

2020 ◽  
Vol 56 (74) ◽  
pp. 10902-10905
Author(s):  
Ruijin Huo ◽  
Xiuli Zheng ◽  
Weimin Liu ◽  
Liping Zhang ◽  
Jiasheng Wu ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Fluorescent Probe ◽  
Sensitive Detection ◽  
Ovarian Cancer Cells ◽  
Normal Cells ◽  
Two Photon ◽  
Glutamyl Transpeptidase

A GGT-activated two-photon fluorescent probe was developed for distinguishing ovarian cancer cells from normal cells.

scholarly journals Benzimidazole based Pt(ii) complexes with better normal cell viability than cisplatin: synthesis, substitution behavior, cytotoxicity, DNA binding and DFT study

RSC Advances ◽  
2016 ◽  
Vol 6 (80) ◽  
pp. 76600-76613 ◽  
Author(s):  
Ishani Mitra ◽  
Subhajit Mukherjee ◽  
Venkata P. Reddy B. ◽  
Subrata Dasgupta ◽  
Jagadeesh C. Bose K ◽  
...  
Keyword(s):  
Dna Binding ◽  
Cell Viability ◽  
Cancer Cells ◽  
Normal Cell ◽  
Water Soluble ◽  
Dft Study ◽  
Normal Cells

Water soluble Pt(ii) complexes with higher viability towards normal cells and comparable cytotoxicity to cancer cells as compared to cisplatin.

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