Engineering anisotropic cardiac monolayers on microelectrode arrays for non-invasive analyses of electrophysiological properties

The Analyst ◽  
2020 ◽  
Vol 145 (1) ◽  
pp. 139-149 ◽  
Author(s):  
Ahmad Alassaf ◽  
Gulistan Tansik ◽  
Vera Mayo ◽  
Laura Wubker ◽  
Daniel Carbonero ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Microelectrode Arrays ◽  
Cardiac Tissues ◽  
Long Term Culture ◽  
Electrophysiological Properties ◽  
Non Invasive

Engineering cardiac tissues with physiological architectural and mechanical properties on microelectrode arrays enables long term culture and non-invasive collection of electrophysiological readouts.

scholarly journals Long-term culture and functionality of pancreatic islets monitored using microelectrode arrays

2014 ◽  
Vol 6 (5) ◽  
pp. 540-544 ◽  
Author(s):  
Sven Schönecker ◽  
Udo Kraushaar ◽  
Martina Düfer ◽  
Anika Sahr ◽  
Carmen Härdtner ◽  
...  
Keyword(s):  
Beta Cell ◽  
Electrical Activity ◽  
Pancreatic Islets ◽  
Beta Cell Function ◽  
Cell Function ◽  
Microelectrode Arrays ◽  
Extracellular Recording ◽  
Long Term Culture

Extracellular recording of the electrical activity of pancreatic islets permits long-term measurements of beta-cell function and reveals oxidant-induced damage and rescue.

scholarly journals Provision of exogenous lipid interacts with maternal BMI to affect human embryo survival in long term culture

2017 ◽  
Vol 108 (3) ◽  
pp. e59-e60
Author(s):  
R. Kile ◽  
Y. Yuan ◽  
H. Silz ◽  
S. McCormick ◽  
W.B. Schoolcraft ◽  
...  
Keyword(s):  
Human Embryo ◽  
Embryo Survival ◽  
Long Term Culture ◽  
Exogenous Lipid ◽  
Maternal Bmi

scholarly journals Taxonomic signatures of cause-specific mortality risk in human gut microbiome

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Aaro Salosensaari ◽  
Ville Laitinen ◽  
Aki S. Havulinna ◽  
Guillaume Meric ◽  
Susan Cheng ◽  
...  
Keyword(s):  
Mortality Risk ◽  
Gut Microbiome ◽  
Human Gut ◽  
Cross Sectional ◽  
Microbiome Composition ◽  
Human Gut Microbiome ◽  
Non Invasive ◽  
Sequencing Technologies

AbstractThe collection of fecal material and developments in sequencing technologies have enabled standardised and non-invasive gut microbiome profiling. Microbiome composition from several large cohorts have been cross-sectionally linked to various lifestyle factors and diseases. In spite of these advances, prospective associations between microbiome composition and health have remained uncharacterised due to the lack of sufficiently large and representative population cohorts with comprehensive follow-up data. Here, we analyse the long-term association between gut microbiome variation and mortality in a well-phenotyped and representative population cohort from Finland (n = 7211). We report robust taxonomic and functional microbiome signatures related to the Enterobacteriaceae family that are associated with mortality risk during a 15-year follow-up. Our results extend previous cross-sectional studies, and help to establish the basis for examining long-term associations between human gut microbiome composition, incident outcomes, and general health status.

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