High-content screening Raman spectroscopy (HCS-RS) of panitumumab-exposed colorectal cancer cells

The Analyst ◽  
2019 ◽  
Vol 144 (20) ◽  
pp. 6098-6107 ◽  
Author(s):  
Abdullah S. Mondol ◽  
Samir F. El-Mashtoly ◽  
Tatjana Frick ◽  
Klaus Gerwert ◽  
Jürgen Popp ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Monoclonal Antibody ◽  
Raman Spectroscopy ◽  
Cancer Cells ◽  
High Content Screening ◽  
Label Free ◽  
Colorectal Cancer Cells

Label-free screening for cancer cells exposed to monoclonal antibody-based drugs using HCS-RS.

scholarly journals Gold nanoparticles conjugated with anti-CD133 monoclonal antibody and 5-fluorouracil chemotherapeutic agent as nanocarriers for cancer cell targeting

RSC Advances ◽  
2021 ◽  
Vol 11 (26) ◽  
pp. 16131-16141
Author(s):  
Manali Haniti Mohd-Zahid ◽  
Siti Nadiah Zulkifli ◽  
Che Azurahanim Che Abdullah ◽  
JitKang Lim ◽  
Sharida Fakurazi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Monoclonal Antibody ◽  
Gold Nanoparticles ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Chemotherapeutic Agent ◽  
Cell Targeting ◽  
Specific Targeting ◽  
Colorectal Cancer Cells ◽  
Cancer Cell Targeting

5-FU-PEGylated AuNPs-CD133 is designed to improve specific targeting of 5-FU against colorectal cancer cells which abundantly express CD133.

scholarly journals Detection and time-tracking activation of a photosensitiser on live single colorectal cancer cells using Raman spectroscopy

The Analyst ◽  
2020 ◽  
Vol 145 (17) ◽  
pp. 5878-5888
Author(s):  
Julia Gala de Pablo ◽  
David R. Chisholm ◽  
Carrie A. Ambler ◽  
Sally A. Peyman ◽  
Andrew Whiting ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Raman Spectroscopy ◽  
Cancer Cells ◽  
Cell Response ◽  
Single Cells ◽  
Colorectal Cancer Cells

Tracking of the accumulation, activation, degradation of a photosensitiser and cell response in live colorectal cancer single-cells using Raman spectroscopy.

scholarly journals Panitumumab and cetuximab affect differently miRNA expression in colorectal cancer cells

2021 ◽  
Author(s):  
Romain Chautard ◽  
Laetitia Corset ◽  
Sajida Ibrahim ◽  
Céline Desvignes ◽  
Gilles Paintaud ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Monoclonal Antibody ◽  
Monoclonal Antibodies ◽  
Cancer Cells ◽  
Two Phase ◽  
Colorectal Cancer Cells ◽  
Significant Expression ◽  
Antibody Resistance ◽  
Phase Process

Structured abstract Background & aim: Resistance to anti-EGFR monoclonal antibodies in metastatic colorectal cancer (CRC) is frequent and prognostic biomarkers are lacking. MicroRNAs (miR) are good candidates in this context. We aimed to characterize cetuximab and panitumumab exposure influence on miR expression in colorectal cancer cells to identify those regulating the EGFR pathway and implicated in resistance to treatment. Finally, we aimed to identify miR expression in serum of patients with advanced CRC treated with cetuximab or panitumumab. Results: Cetuximab and panitumumab exposure induced significant expression variations of 17 miR out of a miRnome panel of 752. Six of those miR interacted with at least one downstream element of the EGFR pathway. Conclusion: After the bioinformatics two-phase process, 5 miR rarely described before could be potential actors of anti-EGFR monoclonal antibody resistance: miR-95-3p, miR-139-5p, miR-145-5p, miR-429 and miR-1247-5p. In vivo, we detected the expression of miR-139-5p and miR-145-5p in serum of patients with metastatic CRC.

Anti-human CD133 Monoclonal Antibody That Could Inhibit the Proliferation of Colorectal Cancer Cells

Hybridoma ◽  
2010 ◽  
Vol 29 (4) ◽  
pp. 305-310 ◽  
Author(s):  
Wei Chen ◽  
Feng Li ◽  
Zhi-Mou Xue ◽  
Hao-Rong Wu
Keyword(s):  
Colorectal Cancer ◽  
Monoclonal Antibody ◽  
Cancer Cells ◽  
Colorectal Cancer Cells

EGFR-targeted immunoliposomes derived from the monoclonal antibody EMD72000 mediate specific and efficient drug delivery to a variety of colorectal cancer cells

2006 ◽  
Vol 14 (4) ◽  
pp. 215-223 ◽  
Author(s):  
Christoph Mamot ◽  
Reto Ritschard ◽  
Willy Küng ◽  
John W. Park ◽  
Richard Herrmann ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Drug Delivery ◽  
Monoclonal Antibody ◽  
Cancer Cells ◽  
Colorectal Cancer Cells
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