Identification and characterization of the inhibitory effect of ART on colorectal cancer cells using Raman spectroscopy

2022 ◽  
Author(s):  
Senmao Chai ◽  
Xiaodong Sun ◽  
Chuhua Fu ◽  
Qianqian Xu ◽  
Zijing Ren ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Raman Spectroscopy ◽  
Cancer Cells ◽  
Inhibitory Effect ◽  
Colorectal Cancer Cells ◽  
Identification And Characterization

scholarly journals MicroRNA-124 Regulates the Proliferation of Colorectal Cancer Cells by TargetingiASPP

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Kuijie Liu ◽  
Hua Zhao ◽  
Hongliang Yao ◽  
Sanlin Lei ◽  
Zhendong Lei ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Target Prediction ◽  
Inhibitory Effect ◽  
Luciferase Reporter ◽  
Luciferase Reporter Gene ◽  
Small Noncoding Rnas ◽  
Colorectal Cancer Cells ◽  
Microrna 124

MicroRNAs are a class of small, noncoding RNAs that function as critical regulators of gene expression by targeting mRNAs for translational repression or degradation. In this study, we demonstrate that expression of microRNA-124 (miR-124) is significantly downregulated in colorectal cancer tissues and cell lines, compared to the matched adjacent tissues. We identified and confirmed inhibitor of apoptosis-stimulating protein of p53 (iASPP) as a novel, direct target of miR-124 using target prediction algorithms and luciferase reporter gene assays. Overexpression of miR-124 suppressed iASPP protein expression, upregulated expression of the downstream signaling molecule nuclear factor-kappa B (NF-κB), and attenuated cell viability, proliferation, and colony formation in SW480 and HT-29 colorectal cancer cells in vitro. Forced overexpression ofiASPPpartly rescued the inhibitory effect of miR-124 on SW480 and HT29 cell proliferation. Taken together, these findings shed light on the role and mechanism of action of miR-124, indicate that the miR-124/iASPP axis can regulate the proliferation of colorectal cancer cells, and suggest that miR-124 may serve as a potential therapeutic target for colorectal cancer.

scholarly journals Detection and time-tracking activation of a photosensitiser on live single colorectal cancer cells using Raman spectroscopy

The Analyst ◽  
2020 ◽  
Vol 145 (17) ◽  
pp. 5878-5888
Author(s):  
Julia Gala de Pablo ◽  
David R. Chisholm ◽  
Carrie A. Ambler ◽  
Sally A. Peyman ◽  
Andrew Whiting ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Raman Spectroscopy ◽  
Cancer Cells ◽  
Cell Response ◽  
Single Cells ◽  
Colorectal Cancer Cells

Tracking of the accumulation, activation, degradation of a photosensitiser and cell response in live colorectal cancer single-cells using Raman spectroscopy.

scholarly journals Characterization of Aes nuclear foci in colorectal cancer cells

2015 ◽  
Vol 159 (1) ◽  
pp. 133-140 ◽  
Author(s):  
Yoshiro Itatani ◽  
Masahiro Sonoshita ◽  
Fumihiko Kakizaki ◽  
Katsuya Okawa ◽  
Stefano Stifani ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Colorectal Cancer Cells ◽  
Nuclear Foci

scholarly journals Novel proapoptotic agent SM-1 enhances the inhibitory effect of 5-fluorouracil on colorectal cancer cells in vitro and in vivo

2017 ◽  
Vol 13 (6) ◽  
pp. 4762-4768 ◽  
Author(s):  
Ying Wang ◽  
Shoujun Yuan ◽  
Linna Li ◽  
Dexuan Yang ◽  
Chengwang Xu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Inhibitory Effect ◽  
Colorectal Cancer Cells

scholarly journals Inhibitory effect of maple syrup on the cell growth and invasion of human colorectal cancer cells

2015 ◽  
Vol 33 (4) ◽  
pp. 1579-1584 ◽  
Author(s):  
TETSUSHI YAMAMOTO ◽  
KENTARO UEMURA ◽  
KAHO MORIYAMA ◽  
KUNIKO MITAMURA ◽  
ATSUSHI TAGA
Keyword(s):  
Colorectal Cancer ◽  
Cell Growth ◽  
Cancer Cells ◽  
Inhibitory Effect ◽  
Human Colorectal Cancer ◽  
Maple Syrup ◽  
Colorectal Cancer Cells ◽  
Human Colorectal Cancer Cells
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