Bio-inspired photonic crystals for naked eye quantification of nucleic acids

The Analyst ◽  
2019 ◽  
Vol 144 (18) ◽  
pp. 5413-5419 ◽  
Author(s):  
Ke Zhu ◽  
Junjie Chi ◽  
Dagan Zhang ◽  
Biao Ma ◽  
Xing Dong ◽  
...  

The quantitative detection of nucleic acids by the naked eye was achieved based on structural color.

Lab on a Chip ◽  
2017 ◽  
Vol 17 (19) ◽  
pp. 3240-3245 ◽  
Author(s):  
Zichen Zhao ◽  
Yuanye Bao ◽  
Lok Ting Chu ◽  
John Kin Lim Ho ◽  
Ching-Chang Chieng ◽  
...  

We demonstrate a microfluidic bead trap capable of forming a dipstick-type bar visible to the naked eye for simple and quantitative detection of oligonucleotides.


2021 ◽  
Author(s):  
Li-Ting Pan ◽  
Zhuo Pen ◽  
Hai-Rong Yu ◽  
Ting Liang ◽  
Chang-Jing Cheng

Highly charged superparamagnetic Fe3O4 colloidal nanocrystal clusters (CNCs) with uniform and widely tunable sizes can be magnetically assembled into responsive photonic crystals to exhibit rapid and reversible brilliant structural color...


2020 ◽  
Vol 117 (48) ◽  
pp. 30107-30117
Author(s):  
Tahmid H. Talukdar ◽  
Bria McCoy ◽  
Sarah K. Timmins ◽  
Taufiquar Khan ◽  
Judson D. Ryckman

Colorimetric sensors offer the prospect for on-demand sensing diagnostics in simple and low-cost form factors, enabling rapid spatiotemporal inspection by digital cameras or the naked eye. However, realizing strong dynamic color variations in response to small changes in sample properties has remained a considerable challenge, which is often pursued through the use of highly responsive materials under broadband illumination. In this work, we demonstrate a general colorimetric sensing technique that overcomes the performance limitations of existing chromatic and luminance-based sensing techniques. Our approach combines structural color optical filters as sensing elements alongside a multichromatic laser illuminant. We experimentally demonstrate our approach in the context of label-free biosensing and achieve ultrasensitive and perceptually enhanced chromatic color changes in response to refractive index changes and small molecule surface attachment. Using structurally enabled chromaticity variations, the human eye is able to resolve ∼0.1-nm spectral shifts with low-quality factor (e.g., Q ∼ 15) structural filters. This enables spatially resolved biosensing in large area (approximately centimeters squared) lithography-free sensing films with a naked eye limit of detection of ∼3 pg/mm2, lower than industry standard sensors based on surface plasmon resonance that require spectral or angular interrogation. This work highlights the key roles played by both the choice of illuminant and design of structural color filter, and it offers a promising pathway for colorimetric devices to meet the strong demand for high-performance, rapid, and portable (or point-of-care) diagnostic sensors in applications spanning from biomedicine to environmental/structural monitoring.


2018 ◽  
Vol 98 (3) ◽  
Author(s):  
Christian D'Ambrosio ◽  
Diana C. Skigin ◽  
Marina E. Inchaussandague ◽  
Ana Barreira ◽  
Pablo Tubaro

1994 ◽  
Vol 77 (2) ◽  
pp. 488-490 ◽  
Author(s):  
Pavel Polak ◽  
Robert L Bradley

Abstract A simple and sensitive assay is described that can detect trace amounts of whey cream in sweet cream and in butter made from that cream. The method is based on the detection of sialic acid and involves a color reaction between Ehrlich’s reagent and sialic acid. The procedure is faster than other methods for detection of whey. The method could be termed semiquantitative because of the seasonal variability of sialic acid in cow’s milk. However, with a calibration curve, the method is quantitative and can easily detect as little as 1% whey cream in sweet cream and in the resulting butter. With 1% whey cream in sweet cream, the purple color indicating the presence of sialic acid is visible to the naked eye.


2017 ◽  
Vol 252 ◽  
pp. 313-321 ◽  
Author(s):  
Hui-juan Yu ◽  
Zhi-feng Hao ◽  
He-long Peng ◽  
Rui-heng Rao ◽  
Ming Sun ◽  
...  

2018 ◽  
Vol 26 (10) ◽  
pp. 13561 ◽  
Author(s):  
Se-Um Kim ◽  
Sin-Hyung Lee ◽  
In-Ho Lee ◽  
Bo-Yeon Lee ◽  
Jun-Hee Na ◽  
...  

2012 ◽  
Vol 33 (5) ◽  
pp. 380-385 ◽  
Author(s):  
Cihui Liu ◽  
Guizhi Gao ◽  
Yuqi Zhang ◽  
Libin Wang ◽  
Jingxia Wang ◽  
...  

2021 ◽  
Author(s):  
Li Feng ◽  
Fen Wang ◽  
Ze Xu ◽  
Hongjie Luo ◽  
Ting Zhao ◽  
...  

Abstract Biomimetic synthesis of amorphous photonic crystals (APCs) is a significant approach to obtain non-iridescent structural colors. However, the structural colors of artificially prepared APCs are dim or even white due to the influence of incoherent scattering. In this paper, we present an innovative method was proposed to combine APCs with black TiO2-x to construct non-iridescent structural color pigments with high visibility and photocatalytic activity. Due to absorption of incoherent scattered light by black TiO2-x, the color saturation of structural colors has been significantly increased. In addition, the utilization rate of photogenic carriers was effectively enhanced by slow light effect generated from pseudo-band gap of SiO2 APCs with TiO2-x absorbed full spectrum. The tone and color saturation of catalytic pigments are controlled by the diameter of SiO2 nanospheres and the ration of TiO2-x nanoparticles, which provides a controllable application study in color related fields such as artwork, environmental coatings and textiles.


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