Study of porphyrin-modified liquid exfoliated graphene field-effect transistors for evaluating DNA methylation degree

The Analyst ◽  
2019 ◽  
Vol 144 (16) ◽  
pp. 4787-4794
Author(s):  
Zhongrong Wang ◽  
Shihui Hu ◽  
Fang Li ◽  
Qingjie Fan ◽  
Yunfang Jia

Recognizing and counting 5-methylcytosine (5mC) sites on ssDNA are realized by porphyrin-modified liquid exfoliated graphene field-effect transistors (TAPP@LEG-FETs).

2014 ◽  
Vol 26 (28) ◽  
pp. 4814-4819 ◽  
Author(s):  
Mirella El Gemayel ◽  
Sébastien Haar ◽  
Fabiola Liscio ◽  
Andrea Schlierf ◽  
Georgian Melinte ◽  
...  

2021 ◽  
Vol 271 ◽  
pp. 04045
Author(s):  
Yunfang Jia ◽  
Jizhao Zhang ◽  
Qingjie Fan

The detection of DNA methylation is necessary for the research of epigenetics. In this work we would like to propose a disposable DNA methylation sensor by using graphene field effect transistor (GFET) as the sensing platform. In this component, the liquid-phase exfoliated graphene (LEG) nanosheets were drop-coated on the flexible substrates of polyethylene terephthalate (PET) films. Then, the interdigital structured electrodes (named as source and drain) were printed on the LEG coated PET films to form the expected GFETs. Thirdly, the carbon dots (CDs) decoration was conducted and examined on the asprepared GFETs to evaluate the influence of CDs, as well as optimize CDs’ concentration. At last, the immune identification-based sensing strategy was utilized on the CDs modified GFETs to develop the concerned DNA methylation sensor. The experimental data indicate the proposed sensors could be a potential experimental tool for epigenetic research.


Polymers ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1046
Author(s):  
Youn Kim ◽  
Yeon Ju Kwon ◽  
Seungwan Ryu ◽  
Cheol Jin Lee ◽  
Jea Uk Lee

We demonstrate that using nanocomposite thin films consisting of semiconducting polymer, poly(3-hexylthiophene) (P3HT), and electrochemically exfoliated graphene (EEG) for the active channel layer of organic field-effect transistors (OFETs) improves both device performances and mechanical properties. The nanocomposite film was developed by directly blending P3HT solution with a dispersion of EEG at various weight proportions and simply transferring to an Si/SiO2 substrate by the solution floating method. The OFET based on P3HT/EEG nanocomposite film showed approximately twice higher field-effect mobility of 0.0391 cm2·V−1·s−1 and one order of magnitude greater on/off ratio of ~104 compared with the OFET based on pristine P3HT. We also measured the mechanical properties of P3HT/EEG nanocomposite film via film-on-elastomer methods, which confirms that the P3HT/EEG nanocomposite film exhibited approximately 2.4 times higher modulus (3.29 GPa) than that of the P3HT film (1.38 GPa), while maintaining the good bending flexibility and durability over 10.0% of bending strain and bending cycles (1000 cycles). It was proved that the polymer hybridization technique, which involves adding EEG to a conjugated polymer, is a powerful route for enhancing both device performances and mechanical properties while maintaining the flexible characteristics of OFET devices.


2018 ◽  
Vol 144 ◽  
pp. 90-94 ◽  
Author(s):  
Jonas Heidler ◽  
Sheng Yang ◽  
Xinliang Feng ◽  
Klaus Müllen ◽  
Kamal Asadi

2008 ◽  
Author(s):  
Takafumi Uemura ◽  
Masakazu Yamagishi ◽  
Yukihiro Tominari ◽  
Jun Takeya

2008 ◽  
Author(s):  
M. Uno ◽  
I. Doi ◽  
K. Takimiya ◽  
Jun Takeya

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