scholarly journals A 90-day subchronic toxicity study of submerged mycelial culture of Cordyceps militaris in rats

2018 ◽  
Vol 7 (5) ◽  
pp. 977-986 ◽  
Author(s):  
Bo-Yi Jhou ◽  
Wei-Chen Fang ◽  
Yen-Lien Chen ◽  
Chin-Chu Chen
Keyword(s):  
Cordyceps Militaris ◽  
Toxicity Study ◽  
Parasitic Fungus ◽  
Subchronic Toxicity ◽  
Mycelial Culture ◽  
Submerged Mycelial Culture

Cordyceps militaris (C. militaris) is a parasitic fungus that grows on the larvae of Lepidoptera.

A 90-Day Subchronic Toxicity Study of Submerged Mycelial Culture of Cordyceps cicadae (Ascomycetes) in Rats

2015 ◽  
Vol 17 (8) ◽  
pp. 771-781 ◽  
Author(s):  
Yen-Lien Chen ◽  
Shu-Hsing Yeh ◽  
Ting-Wei Lin ◽  
Chin-Chu Chen ◽  
Chin-Shuh Chen ◽  
...  
Keyword(s):  
Toxicity Study ◽  
Subchronic Toxicity ◽  
Mycelial Culture ◽  
Cordyceps Cicadae ◽  
Submerged Mycelial Culture

scholarly journals Acute and subchronic toxicity study of nonpolar extract of licorice roots in mice

2020 ◽  
Vol 8 (5) ◽  
pp. 2242-2250
Author(s):  
Hyun‐Yong Kim ◽  
Guanglei Zuo ◽  
Soo Kyeong Lee ◽  
Soon Sung Lim
Keyword(s):  
Toxicity Study ◽  
Subchronic Toxicity

Subchronic toxicity study of the total flavonoids from Rosa laevigata Michx fruit in rats

2012 ◽  
Vol 62 (2) ◽  
pp. 221-230 ◽  
Author(s):  
Shuai Zhang ◽  
Lingli Zheng ◽  
Lina Xu ◽  
Huijun Sun ◽  
Hua Li ◽  
...  
Keyword(s):  
Toxicity Study ◽  
Total Flavonoids ◽  
Subchronic Toxicity ◽  
Rosa Laevigata

scholarly journals Hypoglycemic Effect of aLentinus edodesExo-polymer Producedfrom a Submerged Mycelial Culture

2002 ◽  
Vol 66 (5) ◽  
pp. 937-942 ◽  
Author(s):  
Byung-Keun YANG ◽  
Dong-Hyun KIM ◽  
Sang-Chul JEONG ◽  
Surajit DAS ◽  
Young-Sun CHOI ◽  
...  
Keyword(s):  
Hypoglycemic Effect ◽  
Mycelial Culture ◽  
Submerged Mycelial Culture

Safety assessment of Apoaequorin, a protein preparation: Subchronic toxicity study in rats

2013 ◽  
Vol 57 ◽  
pp. 1-10 ◽  
Author(s):  
Daniel L. Moran ◽  
Palma Ann Marone ◽  
Mark R. Bauter ◽  
Madhu G. Soni
Keyword(s):  
Safety Assessment ◽  
Toxicity Study ◽  
Subchronic Toxicity ◽  
Protein Preparation

scholarly journals Safety assessment of Euglena gracilis ATCC 12894 whole cell biomass

2019 ◽  
Vol 3 ◽  
pp. 239784731989522
Author(s):  
Jennifer Symonds ◽  
Chonggang Zhang ◽  
Adam Noble ◽  
Claire Kruger
Keyword(s):  
Euglena Gracilis ◽  
Safety Assessment ◽  
Wistar Rats ◽  
Micronucleus Assay ◽  
Toxicity Study ◽  
Subchronic Toxicity ◽  
Whole Cell ◽  
Reverse Mutation ◽  
Test Article ◽  
Cell Biomass

A safety assessment of the dried whole cell biomass of Euglena gracilis ATCC 12894 was performed by the bacterial reverse mutation (Ames) assay, an in vitro micronucleus assay, and a 90-day repeat oral toxicity study in Wistar rats. E. gracilis ATCC 12894 whole cell biomass has no added excipients and contains 33.8% protein, 28.8% β-glucans, 19.8% fat, 7.1% ash, and 2.8% moisture. The bacterial reverse mutation assay found no evidence of mutagenicity after exposure to E. gracilis ATCC 12894 whole cell biomass, with or without metabolic activity, at levels up to 1581 µg/plate, the limit dose for the assay. Similarly, no evidence of genotoxicity was observed in the micronucleus assay, with or without metabolic activation, up to 320 µg/mL, the limit dose for the assay. The subchronic toxicity study was performed with the following test article dose groups: 0 (control), 1250, 2500, and 5000 mg/kg/day, administered to male and female Wistar rats via oral gavage for 90 days. No test article-related mortalities or adverse events were reported during the study. Histopathological examination revealed some vacuolation in the livers of males in the 5000 mg/kg/day group. This finding was considered adaptive, due to the approximately 20% fat content of whole cell biomass, and was therefore test article-related, but not adverse. No such findings were reported in female rats in the study. The results of the subchronic toxicity study describe a no observed adverse effect level of at least 5000 mg/kg/day.

Subchronic toxicity study in rats fed gum karaya

1982 ◽  
Vol 20 (5) ◽  
pp. 513-517 ◽  
Author(s):  
P.J.Y. Taupin ◽  
D.M.W. Anderson
Keyword(s):  
Toxicity Study ◽  
Subchronic Toxicity ◽  
Gum Karaya

13‐Week subchronic toxicity study with morpholine oleic acid salt administered to B6C3F1 mice

1987 ◽  
Vol 22 (2) ◽  
pp. 187-194 ◽  
Author(s):  
Masa‐Aki Shibata ◽  
Yasushi Kurata ◽  
Seiko Tamano ◽  
Tadashi Ogiso ◽  
Shoji Fukushima ◽  
...  
Keyword(s):  
Oleic Acid ◽  
Toxicity Study ◽  
Acid Salt ◽  
Subchronic Toxicity ◽  
B6c3f1 Mice
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