Designing nanoparticles with improved tumor penetration: surface properties from the molecular architecture viewpoint

2019 ◽  
Vol 7 (6) ◽  
pp. 953-964 ◽  
Author(s):  
Long Zhang ◽  
Pengyan Hao ◽  
Dejun Yang ◽  
Sheng Feng ◽  
Bo Peng ◽  
...  
Keyword(s):  
Surface Properties ◽  
Cause Of Death ◽  
Molecular Architecture ◽  
Cancer Treatments ◽  
Common Cause ◽  
Tumor Penetration

Cancer is the second most common cause of death, and nanomedicine is regarded as one of the strategies that may revolutionize cancer treatments.

Energy-Sensing Pathways in Ischemia: The Counterbalance Between AMPK and mTORC

2020 ◽  
Vol 25 (45) ◽  
pp. 4763-4770
Author(s):  
Angel Cespedes ◽  
Mario Villa ◽  
Irene Benito-Cuesta ◽  
Maria J. Perez-Alvarez ◽  
Lara Ordoñez ◽  
...  
Keyword(s):  
Blood Flow ◽  
Ischemic Stroke ◽  
Middle Cerebral Artery ◽  
Cause Of Death ◽  
Artery Occlusion ◽  
Brain Pathology ◽  
Common Cause ◽  
Specific Analysis ◽  
Energy Sensing ◽  
Cerebral Artery Occlusion

: Stroke is an important cause of death and disability, and it is the second leading cause of death worldwide. In humans, middle cerebral artery occlusion (MCAO) is the most common cause of ischemic stroke. The damage occurs due to the lack of nutrients and oxygen contributed by the blood flow. : The present review aims to analyze to what extent the lack of each of the elements of the system leads to damage and which mechanisms are unaffected by this deficiency. We believe that the specific analysis of the effect of lack of each component could lead to the emergence of new therapeutic targets for this important brain pathology.

scholarly journals Suicide prevention in low- and middle-income countries: part perceptions, partial solutions

2017 ◽  
Vol 211 (5) ◽  
pp. 264-265 ◽  
Author(s):  
K. S. Jacob
Keyword(s):  
Public Health ◽  
Suicide Prevention ◽  
Cause Of Death ◽  
Population Based ◽  
Personal Distress ◽  
Public Health Perspective ◽  
Middle Income ◽  
Common Cause ◽  
Middle Income Countries ◽  
Low And Middle Income

SummarySuicide, a common cause of death in many low- and middle-income countries, has often been viewed through a medical/psychiatric lens. Such perspectives medicalise social and personal distress and suggest individual and medication-based treatments. This editorial argues for the need to examine suicide from a public health perspective and suggests the need for population-based social and economic interventions.

scholarly journals Choroidal Tubercles, an Ocular Presentation in Tuberculosis- a Retrospective Observational Hospital-based Study

2021 ◽  
pp. 1-6
Author(s):  
Rohit Raina ◽  
Neha Chhabra
Keyword(s):  
Cause Of Death ◽  
Primary Infection ◽  
Visual Loss ◽  
The Body ◽  
Infection Site ◽  
Hospital Record ◽  
Record System ◽  
Ocular Tuberculosis ◽  
Common Cause ◽  
Tuberculosis Patients

Aim: To find the prevalence of choroidal tubercles in tuberculosis patients. Introduction: Tuberculosis is the most common cause of infectious cause of death especially in endemic countries. Tuberculosis infection spreads hematogenously from primary infection site to rest of the body. Ocular presentation manifests in the form of choroidal tubercles being the most common fundus change. Materials and Methods: It was a retrospective, observational hospital-based study. Total 100 tuberculosis patients were studied and their data were collected from Hospital record system from February 2020 to March 2021. Fundus examinations were reviewed and most common ocular presentation was found to be choroidal tubercles. Observations and Results: During the study period, out of 100 patients, 60% were females and 40% were males. Fundus changes were present in 14% patients and these were choroidal tubercles in 12% patients and papillitis in 2%. Choroidal tubercles were present in 7 females and 5 males. Conclusion: We concluded that choroidal tubercles is one of the most common form of ocular tuberculosis. Detection of choroidal inflammation can prevent visual loss as the ocular lesion resolves fully with timely management.

scholarly journals Trueperella (Arcanobacterium pyogenes) in Farmed White-Tailed Deer

EDIS ◽  
2017 ◽  
Vol 2017 (1) ◽  
pp. 3
Author(s):  
Samantha M. Wisely ◽  
Katherin A. Sayler ◽  
Kathryn D. Pothier
Keyword(s):  
Cause Of Death ◽  
Common Cause ◽  
Wildlife Ecology ◽  
Fact Sheet ◽  
Arcanobacterium Pyogenes

Trueperella is a harmless bacterium in intestinal tracts of ruminants like deer, cattle, and pigs, but if it migrates out of the intestine to other areas of an animal’s body and proliferates, it can make the animal sick. Trueperella causes many problems in deer, including lesions, abscesses, and pneumonia, and it is one of the types of bacteria that is known to contribute to the disease lumpy jaw. In young fawns, it is a common cause of death. This 3-page fact sheet written by Kathryn D. Pothier, Katherine A. Sayler, and Samantha M. Wisely and published by the Department of Wildlife Ecology and Conservation explains how to spot and treat trueperella, or, better yet, prevent it in the first place.­http://edis.ifas.ufl.edu/uw427

Stroke

2020 ◽  
pp. 383-388
Author(s):  
Perry Elliott ◽  
Pier D. Lambiase ◽  
Dhavendra Kumar
Keyword(s):  
Sickle Cell Disease ◽  
Fabry Disease ◽  
Cause Of Death ◽  
Sickle Cell ◽  
Single Gene ◽  
Cerebral Haemorrhage ◽  
Developed Countries ◽  
Common Cause ◽  
The Third ◽  
Moya Moya Disease

Stroke is the third most common cause of death, and the most common cause of disability in developed countries. This chapter examines the genetics of stroke, and single gene causes (although stroke is often just one component of the phenotype). It then describes Anderson—Fabry disease, CADASIL, RVCL, autosomal-dominant porencephaly and infantile hemiparesis, hereditary cerebral haemorrhage with amyloidosis, Moya-Moya disease, sickle cell disease, and MELAS.

Theatre-Based Hospital Placements for Firefighters

2005 ◽  
Vol 15 (9) ◽  
pp. 396-399
Author(s):  
Emma Durmaz
Keyword(s):  
Laryngeal Mask Airway ◽  
Airway Management ◽  
Airway Obstruction ◽  
Cause Of Death ◽  
Pilot Project ◽  
Laryngeal Mask ◽  
Common Cause ◽  
Consultant Anaesthetist ◽  
Management Techniques ◽  
One Year

Airway obstruction is the most common cause of death in the prehospital environment. It is estimated that 85% of these patients had otherwise survivable injuries. The aim of the project was to increase firefighters' skills in airway management techniques, to include the laryngeal mask airway (LMA), by providing theatre-based hospital placements under the supervision of a consultant anaesthetist. The training in the use of the LMA by firefighters is currently a pilot project to assess the potential for its use operationally, based on ease of training to a competent level and retention of skills after one year.

scholarly journals Survival after Liver Transplantation for Hepatitis C Is Unchanged over Two Decades in Canada

2008 ◽  
Vol 22 (2) ◽  
pp. 153-154 ◽  
Author(s):  
Kymberly DS Watt ◽  
Kelly W Burak ◽  
Marc Deschênes ◽  
Les Lilly ◽  
Denis Marleau ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Cause Of Death ◽  
Survival Rates ◽  
Hcv Infection ◽  
Common Cause ◽  
Allograft Failure ◽  
Survival Difference ◽  
Registry Database

Allograft failure secondary to recurrence of hepatitis C virus (HCV) infection is the most common cause of death and retransplantation among recipients with HCV infection. It has been suggested that patients transplanted for HCV have had worse outcomes in more recent years than in previous years (the ‘era effect’). A Canadian transplantation registry database was analyzed to determine the outcomes of patients transplanted over the years for HCV. The results of the present analysis of 1002 patients show that the ‘era effect’ was not seen in liver transplantation recipients with HCV in Canada, because no survival difference was noted based on the year of transplantation. All groups had overall two-year and five-year survival rates of 76% to 83% and 69% to 72%, respectively. The present study’s national results prove continued benefit to transplantation of HCV patients.

Pesticide intoxications in Cukurova, Turkey: three years analysis

2011 ◽  
Vol 30 (12) ◽  
pp. 1892-1895 ◽  
Author(s):  
Nebile Daglioglu ◽  
Ramazan Akcan ◽  
Mete Korkut Gulmen ◽  
Fadile Yener ◽  
Pinar Efeoglu
Keyword(s):  
Cause Of Death ◽  
Forensic Medicine ◽  
Forensic Toxicology ◽  
Pesticide Poisoning ◽  
Pesticide Analysis ◽  
Common Cause

In Cukurova region, pesticide poisonings still remain an unfortunate cause of death, which led to the present study. The autopsy records of Adana Branch of the Council of Forensic Medicine, between 2006 and 2008, were evaluated retrospectively. Deaths that were attributed to pesticide poisoning were included in the scope of the study to identify the type of pesticide, and etiology of intoxication. The frequency and distribution of intoxications were also analyzed in terms of sex and age. In the studied period, a total of 4199 autopsies were referred to the forensic toxicology laboratory for pesticide analysis. Seventy-two cases were positive for pesticide analysis. Of these, 42 (58.33%) were male and 30 (41.67%) were female, with a mean age of 38.8 ± 20.6 years. Among the inspected pesticides, endosulfan was found to be the most common with 47.2% of prevalence, followed by dichlorvos. This report showed that certain pesticides, endosulfan in particular, remains as common cause of poisonings in Cukurova region.

Diagnosis and assessment of stroke

2016 ◽  
Author(s):  
Candice Delcourt ◽  
Craig Anderson
Keyword(s):  
Heart Disease ◽  
Ischaemic Stroke ◽  
Ischaemic Heart Disease ◽  
Cause Of Death ◽  
Physical Disability ◽  
Early Phase ◽  
Haemorrhagic Stroke ◽  
Common Cause ◽  
The World ◽  
The Impact

Approximately 20 million strokes occur in the world each year and over one-quarter of these are fatal. This makes stroke the second most common cause of death, after ischaemic heart disease, and strokes are responsible for 6 million deaths (almost 10% of all deaths) annually. Stroke has major consequences in terms of residual physical disability, depression, dementia, epilepsy, and carer burden. Moreover, around 20% of survivors experience a further stroke or serious vascular event within a few years of the index event. Ischaemic stroke contributes the greatest share of the impact of stroke, with a rate of approximately 1 in 1000 person-years and accounting for between 60% (in Asia) and 90% (in Western ‘white’ populations) of all strokes around the world. Diagnosis and assessment are essentially clinical and confirmed by CT or MRI scanning. Prognostication is difficult in the early phase of haemorrhagic stroke and in ischaemic stroke is affected by the availability and timely use of treatments to recanalize the occluded vessel.

Sign in / Sign up

Export Citation Format

Share Document