Emerging biomedical applications of polyaspartic acid-derived biodegradable polyelectrolytes and polyelectrolyte complexes

2019 ◽  
Vol 7 (13) ◽  
pp. 2102-2122 ◽  
Author(s):  
Prabhu Srinivas Yavvari ◽  
Anand Kumar Awasthi ◽  
Aashish Sharma ◽  
Avinash Bajaj ◽  
Aasheesh Srivastava
Keyword(s):  
Aspartic Acid ◽  
Biomedical Applications ◽  
Tissue Adhesives ◽  
Polyaspartic Acid ◽  
Polyelectrolyte Complexes

A summary of positive biomedical attributes of biodegradable polyelectrolytes (PELs) prepared from aspartic acid is provided. The utility of these PELs in emerging applications such as biomineralization modulators, antimycobacterials, biocompatible cell encapsulants and tissue adhesives is highlighted.

scholarly journals Polyelectrolyte Complexes of Natural Polymers and Their Biomedical Applications

Polymers ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 672 ◽  
Author(s):  
Masayuki Ishihara ◽  
Satoko Kishimoto ◽  
Shingo Nakamura ◽  
Yoko Sato ◽  
Hidemi Hattori
Keyword(s):  
Biomedical Applications ◽  
Electrostatic Interactions ◽  
Biological Activities ◽  
Wound Dressings ◽  
Natural Polymers ◽  
Tissue Adhesives ◽  
Chitosan Hydrogel ◽  
Polyelectrolyte Complexes ◽  
Micro Particles ◽  
Positively Charged

Polyelectrolyte complexes (PECs), composed of natural and biodegradable polymers, (such as positively charged chitosan or protamine and negatively charged glycosaminoglycans (GAGs)) have attracted attention as hydrogels, films, hydrocolloids, and nano-/micro-particles (N/MPs) for biomedical applications. This is due to their biocompatibility and biological activities. These PECs have been used as drug and cell delivery carriers, hemostats, wound dressings, tissue adhesives, and scaffolds for tissue engineering. In addition to their comprehensive review, this review describes our original studies and provides an overview of the characteristics of chitosan-based hydrogel, including photo-cross-linkable chitosan hydrogel and hydrocolloidal PECs, as well as molecular-weight heparin (LH)/positively charged protamine (P) N/MPs. These are generated by electrostatic interactions between negatively charged LH and positively charged P together with their potential biomedical applications.

scholarly journals Effect of polyaspartic acid on pharmacokinetics of gentamicin after single intravenous dose in the dog.

1996 ◽  
Vol 40 (5) ◽  
pp. 1237-1241 ◽  
Author(s):  
T Whittem ◽  
K Parton ◽  
K Turner
Keyword(s):  
Aspartic Acid ◽  
Elimination Rate ◽  
Volume Of Distribution ◽  
Intravenous Dose ◽  
Pharmacokinetic Parameters ◽  
Therapeutic Drug ◽  
Peripheral Compartment ◽  
Single Intravenous Dose ◽  
Polyaspartic Acid ◽  
Peripheral Tissues

The effects of poly-L-aspartic acid on the pharmacokinetics of gentamicin were examined by using a randomized crossover trial design with the dog. When analyzed according to a three-compartment open model, poly-L-aspartic acid reduced some first-order rate equation constants (A3, lambda 1, and lambda 3), the deep peripheral compartment exit microconstant (k31), the elimination rate constant (k(el)), and the area under the concentration-time curve from 0 to 480 h (AUC0-480) (0.21-, 0.60-, 0.26-, 0.27-, 0.72-, and 0.76-fold, respectively; P < 0.05) but increased the volume of distribution at steady state (Vss), the volume of distribution calculated by the area method (V(area)), the apparent volume of the peripheral compartment (Vp), and all mean time parameters. These results suggested that poly-L-aspartic acid increased the distribution of gentamicin to or binding within the deep peripheral compartment and that poly-L-aspartic acid may have delayed gentamicin transit through the peripheral tissues. In contrast, poly-L-aspartic acid did not alter pharmacokinetic parameters relevant to the central or shallow peripheral compartments to a clinically significant extent. Although gentamicin's pharmacokinetic parameters of relevance to therapeutic drug monitoring were not directly altered, this study has provided pharmacokinetic evidence that poly-L-aspartic acid alters the peripheral distribution of gentamicin. This pharmacokinetic interaction occurred after a single intravenous dose of each drug. Therefore, this interaction should be investigated further, before polyaspartic acid can be considered for use as a clinical nephroprotectant.

scholarly journals Influence of the SolubleInsoluble Ratios of Cyclodextrins Polymers on the Viscoelastic Properties of Injectable ChitosanBased Hydrogels for Biomedical Application

Polymers ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 214 ◽  
Author(s):  
Carla Palomino-Durand ◽  
Marco Lopez ◽  
Frédéric Cazaux ◽  
Bernard Martel ◽  
Nicolas Blanchemain ◽  
...  
Keyword(s):  
Viscoelastic Properties ◽  
Biomedical Applications ◽  
Structural Integrity ◽  
Biomedical Application ◽  
Water Soluble ◽  
Self Healing ◽  
Indirect Contact ◽  
Polyelectrolyte Complexes ◽  
Anionic Polymers ◽  
The Difference

Injectable pre-formed physical hydrogels provide many advantages for biomedical applications. Polyelectrolyte complexes (PEC) formed between cationic chitosan (CHT) and anionic polymers of cyclodextrin (PCD) render a hydrogel of great interest. Given the difference between water-soluble (PCDs) and water-insoluble PCD (PCDi) in the extension of polymerization, the present study aims to explore their impact on the formation and properties of CHT/PCD hydrogel obtained from the variable ratios of PCDi and PCDs in the formulation. Hydrogels CHT/PCDi/PCDs at weight ratios of 3:0:3, 3:1.5:1.5, and 3:3:0 were elaborated in a double–syringe system. The chemical composition, microstructure, viscoelastic properties, injectability, and structural integrity of the hydrogels were investigated. The cytotoxicity of the hydrogel was also evaluated by indirect contact with pre-osteoblast cells. Despite having similar shear–thinning and self-healing behaviors, the three hydrogels showed a marked difference in their rheological characteristics, injectability, structural stability, etc., depending on their PCDi and PCDs contents. Among the three, all the best above-mentioned properties, in addition to a high cytocompatibility, were found in the hydrogel 3:1.5:1.5. For the first time, we gained a deeper understanding of the role of the PCDi/PCDs in the injectable pre-formed hydrogels (CHT/PCDi/PCDs), which could be further fine-tuned to enhance their performance in biomedical applications.

Development of Antibacterial Xanthan/Chitosan Biguanidine Hydrochlo ride Polyelectrolyte Complexes Decorated with Eco-friendly Prepared Silver Nanoparticles

2020 ◽  
Vol 10 ◽  
Author(s):  
Hend Ezzat Salama ◽  
Mohamed Samir Abdel Aziz
Keyword(s):  
Silver Nanoparticles ◽  
Biomedical Applications ◽  
Decomposition Temperature ◽  
Homogeneous Distribution ◽  
Face Centered Cubic ◽  
Polyelectrolyte Complexes ◽  
X Ray ◽  
Integral Procedure ◽  
Face Centered ◽  
Average Size

Background:: Novel eco-friendly silver nanocomposites of xanthan/chitosan biguanidine hydrochloride polyelectrolyte complexes were successfully prepared. Methods:: Silver nanoparticles (AgNPs) were formed through an insitu eco-friendly reduction by the non-toxic polysaccharides without the usage of toxic reagents. FTIR confirmed the successful preparation of the nanocomposites while XRD confirmed the presence of AgNPs with face-centered cubic structures. TEM confirmed the homogeneous distribution of AgNPs with an average size of 14.1 nm. SEM was used to study the surface morphology of the nanocomposites while the energy-dispersive X-ray spectroscopy (EDX) confirmed the presence of AgNPs. Results:: Thermogravimetric analysis showed that the thermal stability was improved in the presence of AgNPs as detected from the calculated integral procedure decomposition temperature. Antibacterial activity against different bacteria species was significantly improved upon increasing the content of AgNPs. Conclusion:: Due to their interesting properties, the prepared polyelectrolyte complexes and their AgNPs nanocomposites could be employed potentially in many biomedical applications like drug delivery.

scholarly journals A Review of Gum Hydrocolloid Polyelectrolyte Complexes (PEC) for Biomedical Applications: Their Properties and Drug Delivery Studies

Processes ◽  
2021 ◽  
Vol 9 (10) ◽  
pp. 1796
Author(s):  
Jindrayani Nyoo Putro ◽  
Valentino Bervia Lunardi ◽  
Felycia Edi Soetaredjo ◽  
Maria Yuliana ◽  
Shella Permatasari Santoso ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Order Equation ◽  
Zero Order ◽  
Natural Polymers ◽  
Polyelectrolyte Complexes ◽  
First Order ◽  
Natural Gum

The utilization of natural gum polysaccharides as the vehicle for drug delivery systems and other biomedical applications has increased in recent decades. Their biocompatibility, biodegradability, and price are much cheaper than other materials. It is also renewable and available in massive amounts, which are the main reasons for its use in pharmaceutical applications. Gum can be easily functionalized with other natural polymers to enhance their applications. Various aspects of the utilization of natural gums in the forms of polyelectrolyte complexes (PECs) for drug delivery systems are discussed in this review. The application of different mathematical models were used to represent the drug release mechanisms from PECs; these models include a zero-order equation, first-order equation, Higuchi, simplified Higuchi, Korsmeyer–Peppas, and Peppas–Sahlin.

scholarly journals Poly(aspartic acid) Biohydrogel as the Base of a New Hybrid Conducting Material

2021 ◽  
Vol 22 (23) ◽  
pp. 13165
Author(s):  
Adrián Fontana-Escartín ◽  
Guillem Ruano ◽  
Fiorella M. Silva ◽  
Francesc Estrany ◽  
Jordi Puiggalí ◽  
...  
Keyword(s):  
Electrochemical Properties ◽  
Aspartic Acid ◽  
Conducting Polymer ◽  
Biomedical Applications ◽  
Polymer Network ◽  
Conducting Material ◽  
Electrically Conductive ◽  
Biodegradable Hydrogel ◽  
New Material ◽  
Cross Linker

In the present study, a composite made of conducting polymer, poly(3,4-ethylenedioxythiophene) (PEDOT), and a biodegradable hydrogel of poly(aspartic acid) (PASP) were electrochemically interpenetrated with poly(hydroxymethyl-3,4-ethylenedioxythiophene) (PHMeDOT) to prepare a new interpenetrated polymer network (IPN). Different cross-linker and PEDOT MPs contents, as well as different electropolymerization times, were studied to optimize the structural and electrochemical properties. The properties of the new material, being electrically conductive, biocompatible, bioactive, and biodegradable, make it suitable for possible uses in biomedical applications.

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