Phthalocyanine-based photosensitizer with tumor-pH-responsive properties for cancer theranostics

2018 ◽  
Vol 6 (38) ◽  
pp. 6080-6088 ◽  
Author(s):  
Shufeng Yan ◽  
Jincan Chen ◽  
Liangzhi Cai ◽  
Peng Xu ◽  
Yaxin Zhang ◽  
...  
Keyword(s):  
Ph Responsive ◽  
Tumor Ph ◽  
Cancer Theranostics

A versatile phthalocyanine-based photosensitizer with tumor-pH-responsive properties for cancer theranostics.

Highly photostable croconium dye-anchored cell membrane vesicle for tumor pH-responsive duplex imaging-guided photothermal therapy

Biomaterials ◽  
2021 ◽  
Vol 267 ◽  
pp. 120454
Author(s):  
Xiaoting Gao ◽  
Shanshan Jiang ◽  
Chunying Li ◽  
Yunzhi Chen ◽  
Yifan Zhang ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Photothermal Therapy ◽  
Membrane Vesicle ◽  
Ph Responsive ◽  
Tumor Ph ◽  
Duplex Imaging

NIR imaging-guided combined photodynamic therapy and chemotherapy by a pH-responsive amphiphilic polypeptide prodrug

2017 ◽  
Vol 5 (2) ◽  
pp. 313-321 ◽  
Author(s):  
Zheng Ruan ◽  
Le Liu ◽  
Wei Jiang ◽  
Shuya Li ◽  
Yucai Wang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Ph Responsive ◽  
Nir Imaging ◽  
Cancer Theranostics

Polypeptide micelles conjugated with DOX and a NIR photosensitizer can be used as imaging-guided PDT agents for cancer theranostics.

scholarly journals Tumor pH-responsive flower-like micelles of poly(l-lactic acid)-b-poly(ethylene glycol)-b-poly(l-histidine)

2007 ◽  
Vol 123 (1) ◽  
pp. 19-26 ◽  
Author(s):  
Eun Seong Lee ◽  
Kyung Taek Oh ◽  
Dongin Kim ◽  
Yu Seok Youn ◽  
You Han Bae
Keyword(s):  
Lactic Acid ◽  
Ethylene Glycol ◽  
Ph Responsive ◽  
Poly Ethylene Glycol ◽  
Tumor Ph ◽  
Poly Ethylene

Tumor pH-Responsive Release of Drug-Conjugated Micelles from Fiber Fragments for Intratumoral Chemotherapy

2017 ◽  
Vol 9 (38) ◽  
pp. 32534-32544 ◽  
Author(s):  
Nan He ◽  
Zhoujiang Chen ◽  
Jiang Yuan ◽  
Long Zhao ◽  
Maohua Chen ◽  
...  
Keyword(s):  
Ph Responsive ◽  
Intratumoral Chemotherapy ◽  
Tumor Ph

A tumor pH-responsive complex: Carboxyl-modified hyperbranched polyether and cis-dichlorodiammineplatinum(II)

2011 ◽  
Vol 88 (2) ◽  
pp. 674-681 ◽  
Author(s):  
Yumin Xia ◽  
Yimin Wang ◽  
Yanping Wang ◽  
Chunlai Tu ◽  
Feng Qiu ◽  
...  
Keyword(s):  
Ph Responsive ◽  
Tumor Ph ◽  
Hyperbranched Polyether

scholarly journals A Tumor-pH-Responsive Supramolecular Photosensitizer for Activatable Photodynamic Therapy with Minimal In Vivo Skin Phototoxicity

Theranostics ◽  
2017 ◽  
Vol 7 (10) ◽  
pp. 2746-2756 ◽  
Author(s):  
Xingshu Li ◽  
Bi-Yuan Zheng ◽  
Mei-Rong Ke ◽  
Yongfan Zhang ◽  
Jian-Dong Huang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Ph Responsive ◽  
Tumor Ph

Tumor-pH-Responsive Dissociable Albumin-Tamoxifen Nanocomplexes Enabling Efficient Tumor Penetration and Hypoxia Relief for Enhanced Cancer Photodynamic Therapy

Small ◽  
2018 ◽  
Vol 14 (49) ◽  
pp. 1803262 ◽  
Author(s):  
Zhijuan Yang ◽  
Qian Chen ◽  
Jiawen Chen ◽  
Ziliang Dong ◽  
Rui Zhang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Ph Responsive ◽  
Tumor Penetration ◽  
Tumor Ph

scholarly journals Acidic Tumor pH-Responsive Nanophotomedicine for Targeted Photodynamic Cancer Therapy

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Wooram Park ◽  
Sin-jung Park ◽  
Heejun Shin ◽  
Kun Na
Keyword(s):  
Cancer Therapy ◽  
Self Assembly ◽  
Ph Responsive ◽  
Imine Group ◽  
Tumor Ph ◽  
Methoxypolyethylene Glycol ◽  
Photodynamic Cancer Therapy ◽  
Cervical Cancer Cells ◽  
Targeted Photodynamic Therapy

An acidic tumor pH-responsive nanophotomedicine (pH-NanoPM) for targeted photodynamic therapy (PDT) was demonstrated herein. The pH-NanoPM was prepared with a size of ~110 nm by self-assembly of a pH-responsive polymeric photosensitizer (pH-PPS) consisting of pH-cleavable methoxypolyethylene glycol (pH-C-mPEG). Because the pH-C-mPEG can be detached from the nanoparticles by hydrolysis of the benzoic-imine group at the pH of an acidic tumor (~6.5), the particle size and surface charge of the pH-NanoPM were changed along with the environmental pH condition. After detachment of the pH-C-mPEG, the pH-NanoPM particles became positively charged (+18.67±1.95 mV) due to exposure of primary amine groups and decreased to a size of ~40 nm. Fromin vitrocellular experiments with HeLa human cervical cancer cells, the pH-NanoPM exhibited enhanced cellular internalization at acidic tumor pH compared to normal pH, which led to a significant cancer cell killing effect. These results suggest that this system has the potential to be used as a new class of nanophotomedicine for targeted photodynamic cancer therapy.

Human serum albumin-based doxorubicin prodrug nanoparticles with tumor pH-responsive aggregation-enhanced retention and reduced cardiotoxicity

2020 ◽  
Vol 8 (17) ◽  
pp. 3939-3948 ◽  
Author(s):  
Boya Zhang ◽  
Shiyu Wan ◽  
Xinyu Peng ◽  
Mingying Zhao ◽  
Sai Li ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Ph Sensitive ◽  
Ph Responsive ◽  
Tumor Ph ◽  
Tumor Retention

A nano-assembly of pH-sensitive doxorubicin prodrug and human serum albumin shows tumor pH-responsive aggregation, enhanced tumor retention and reduced cytotoxicity.

Sign in / Sign up

Export Citation Format

Share Document