Iron oxide nanoparticles for targeted imaging of liver tumors with ultralow hepatotoxicity

2018 ◽  
Vol 6 (40) ◽  
pp. 6413-6423 ◽  
Author(s):  
Juanjuan Li ◽  
Ruitao Cha ◽  
Yulong Zhang ◽  
Hongbo Guo ◽  
Keying Long ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Liver Tumors ◽  
Mri Contrast Agents ◽  
Oxide Nanoparticles ◽  
Targeted Imaging ◽  
Resonance Imaging ◽  
Mri Contrast ◽  
Magnetic Resonance Imaging Mri

Even though iron oxide (Fe3O4) nanoparticles are promising materials for magnetic resonance imaging (MRI) contrast agents, their biocompatibility and targeting efficacy still need to be improved.

Silica-coated super-paramagnetic iron oxide nanoparticles (SPIONPs): a new type contrast agent of T1 magnetic resonance imaging (MRI)

2015 ◽  
Vol 3 (26) ◽  
pp. 5172-5181 ◽  
Author(s):  
M. Zubair Iqbal ◽  
Xuehua Ma ◽  
Tianxiang Chen ◽  
Ling'e Zhang ◽  
Wenzhi Ren ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Oxide Nanoparticles ◽  
Resonance Imaging ◽  
Mri Contrast ◽  
New Type ◽  
Magnetic Resonance Imaging Mri

Silica-coated-SPIONPs-T1 enhanced MRI contrast agents.

EDTMP ligand-enhanced water interaction endowing iron oxide nanoparticles with dual-modal MRI contrast ability

2021 ◽  
Author(s):  
Lili Hao ◽  
Peng Wang ◽  
Zhenxu Wu ◽  
Zongliang Wang ◽  
Yu Wang ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Iron Oxide Nanoparticles ◽  
Mri Contrast Agents ◽  
Oxide Nanoparticles ◽  
Resonance Imaging ◽  
Mri Contrast ◽  
Water Interaction ◽  
Magnetic Resonance Imaging Mri

Single-modal magnetic resonance imaging (MRI) contrast agents sometimes causes signal confusion in clinical diagnosis. Utilizing ligands to endow iron oxide nanoparticles (IO NPs) with excellent dual-modal MRI contrast efficiency might...

scholarly journals Magnetism for Drug Delivery, MRI and Hyperthermia Applications: a Review

2020 ◽  
Vol 11 (2) ◽  
pp. 8654-8668
Keyword(s):  
Magnetic Resonance Imaging ◽  
Drug Delivery ◽  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Magnetic Resonance ◽  
Mri Contrast Agents ◽  
Oxide Nanoparticles ◽  
Resonance Imaging ◽  
Mri Contrast ◽  
Magnetic Resonance Imaging Mri

Superparamagnetic nanoparticles contain unique magnetic properties that differ from the bulk materials and are able to function at a cellular level due to their size, shape, and surface characteristics. These features make them attractive candidates for drug delivery systems, thermal mediators in hyperthermia, and magnetic resonance imaging (MRI) contrast agents. This review provides an up-to-date overview of the application of iron oxide nanoparticles in cancer diagnosis, drug delivery, treatment, and safety concerns related to these materials are considered, as well. Furthermore, the general principles and challenges of the magnetic behavior of nanoparticles in the field of oncology are also discussed. Firstly, the basic requirements for magnetic nanoparticles for biomedical applications are outlined. The close link between structure, shape, size, and magnetic characterization are described, which is considered essential for non-invasive imaging modality, innovative magnetic-driven nanocarriers, and treatment based on the overheating. In conclusion, investigation of the toxicity profile of novel nanoparticles is provided, as well. In the current review, the attention is focused on the role of magnetic nanoparticles, especially iron oxide nanoparticles in some bioapplications such as magnetic resonance imaging (MRI) contrast agents, targeted drug delivery, and magnetic hyperthermia systems.

Biocompatible dextran-coated gadolinium-doped cerium oxide nanoparticles as MRI contrast agents with high T1 relaxivity and selective cytotoxicity to cancer cells

2021 ◽  
Author(s):  
Anton Popov ◽  
Maxim Artemovich Abakumov ◽  
Irina Savintseva ◽  
Artem Ermakov ◽  
Nelly Popova ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Resonance Imaging ◽  
Mri Contrast ◽  
Selective Cytotoxicity ◽  
Magnetic Resonance Imaging Mri

Gd-based complexes are widely used as magnetic resonance imaging (MRI) contrast agents. The safety of previously approved contrast agents is questionable and is being re-assessed. The main causes of concern...

scholarly journals Effect of Gd and Dy Concentrations in Layered Double Hydroxides on Contrast in Magnetic Resonance Imaging

Processes ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 462 ◽  
Author(s):  
Karina Nava Andrade ◽  
Gregorio Guadalupe Carbajal Arízaga ◽  
José Antonio Rivera Mayorga
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Resonance Imaging ◽  
Mri Contrast ◽  
Molar Ratios ◽  
Magnetic Resonance Imaging Mri ◽  
Double Hydroxide ◽  
Double Hydroxides

In this work, we explore the synthesis of layered double hydroxide (LDH) particles containing different molar ratios of Gd3+ and Dy3+ cations. A single crystalline phase was obtained for Zn2.0Al0.75Gd0.125Dy0.125-LDH and Zn2.0Al0.5Gd0.25Dy0.25-LDH, and their efficiency as contrast agents was evaluated by T1- and T2-weighted magnetic resonance imaging (MRI). Both GdDy-LDHs exhibited longitudinal relaxivity (r1) higher than a commercial reference. The highest contrast in the T1 mode was achieved with the Zn2.0Al0.75Gd0.125Dy0.125-LDH, which contained the lowest concentration of lanthanides; this efficiency is related to the lowest amount of carbonate anions complexing the lanthanide sites. On the contrary, the best contrast in the T2 mode was achieved with Zn2.0Al0.5Gd0.25Dy0.25-LDH. Zn2.0Al0.75Gd0.125Dy0.125-LDH and Zn2.0Al0.5Gd0.25Dy0.25-LDH presented r2/r1 ratios of 7.9 and 22.5, respectively, indicating that the inclusion of gadolinium and dysprosium into layered structures is a promising approach to the development of efficient bimodal (T1/T2) MRI contrast agents.

scholarly journals Ferritin: A Platform for MRI Contrast Agents Delivery

Inorganics ◽  
2019 ◽  
Vol 7 (3) ◽  
pp. 33 ◽  
Author(s):  
Maria Ruggiero ◽  
Diego Alberti ◽  
Valeria Bitonto ◽  
Simonetta Geninatti Crich
Keyword(s):  
Magnetic Resonance Imaging ◽  
Targeted Therapy ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Resonance Imaging ◽  
Mri Contrast ◽  
Magnetic Resonance Imaging Mri ◽  
Accurate Imaging ◽  
Unique Surface

The search for high relaxivities and increased specificity continues to be central to the development of paramagnetic contrast agents for magnetic resonance imaging (MRI). Ferritin, due to its unique surface properties, architecture, and biocompatibility, has emerged as a natural nanocage that can potentially help to reach both these goals. This review aims to highlight recent advances in the use of ferritin as a nanoplatform for the delivery of metal-based MRI contrast agents (containing Gd3+, Mn2+, or Fe2O3) alone or in combination with active molecules used for therapeutic purposes. The collected results unequivocally show that the use of ferritin for contrast agent delivery leads to more accurate imaging of cancer cells and a significantly improved targeted therapy.

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