A multifunctional luminogen with aggregation-induced emission characteristics for selective imaging and photodynamic killing of both cancer cells and Gram-positive bacteria

2018 ◽  
Vol 6 (23) ◽  
pp. 3894-3903 ◽  
Author(s):  
Miaomiao Kang ◽  
Ryan T. K. Kwok ◽  
Jianguo Wang ◽  
Han Zhang ◽  
Jacky W. Y. Lam ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Emission Characteristics ◽  
Gram Positive ◽  
Aggregation Induced Emission ◽  
Gram Positive Bacteria ◽  
Positively Charged

A positively charged multifunctional AIEgen was developed for selective imaging and photodynamic killing of cancer cells as well as Gram-positive bacteria.

Efficient photosensitizers with aggregation-induced emission characteristics for lysosome- and Gram-positive bacteria-targeted photodynamic therapy

2020 ◽  
Vol 56 (17) ◽  
pp. 2630-2633 ◽  
Author(s):  
Jiabao Zhuang ◽  
Hanxiao Yang ◽  
Yue Li ◽  
Bing Wang ◽  
Nan Li ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Cells ◽  
White Light ◽  
Light Irradiation ◽  
Emission Characteristics ◽  
Gram Positive ◽  
Aggregation Induced Emission ◽  
Gram Positive Bacteria ◽  
Targeted Photodynamic Therapy

Efficient photosensitizers with aggregation-induced emission effects were reported to selectively stain lysosome and Gram-positive bacteria, which further triggered the ablation of cancer cells and bacteria under white light irradiation.

A light-up probe with aggregation-induced emission characteristics (AIE) for selective imaging, naked-eye detection and photodynamic killing of Gram-positive bacteria

2015 ◽  
Vol 51 (62) ◽  
pp. 12490-12493 ◽  
Author(s):  
Guangxue Feng ◽  
Youyong Yuan ◽  
Hu Fang ◽  
Ruoyu Zhang ◽  
Bengang Xing ◽  
...  
Keyword(s):  
Selective Recognition ◽  
Emission Characteristics ◽  
Eye Detection ◽  
Gram Positive ◽  
Aggregation Induced Emission ◽  
Gram Positive Bacteria ◽  
Naked Eye ◽  
Resistant Strains ◽  
Vancomycin Resistant ◽  
Naked Eye Detection

We report a multifunctional light-up probe based on AIEgens for selective recognition, naked-eye identification, and photodynamic killing of Gram-positive bacteria including vancomycin-resistant strains.

Synthesis, structures and biomolecular interactions of new silver(i) 5,5-diethylbarbiturate complexes of monophosphines targeting Gram-positive bacteria and breast cancer cells

2017 ◽  
Vol 46 (25) ◽  
pp. 8110-8124 ◽  
Author(s):  
Veysel T. Yilmaz ◽  
Ceyda Icsel ◽  
Jenaidullah Batur ◽  
Seyma Aydinlik ◽  
Murat Cengiz ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Antimicrobial Activity ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Biomolecular Interactions ◽  
High Antimicrobial Activity ◽  
Gram Positive ◽  
Gram Positive Bacteria ◽  
Very High ◽  
Mcf 7

New silver(i) 5,5-diethylbarbiturate complexes exhibit very high antimicrobial activity against Gram-positive bacteria and kill MCF-7 cells, damaging mitochondria and DNA.

scholarly journals NMR Hydrophilic Metabolomic Analysis of Bacterial Resistance Pathways using Multivalent Antimicrobials with Challenged and Unchallenged Wild Type and Mutated Gram-Positive Bacteria

2021 ◽  
Vol 22 (24) ◽  
pp. 13606
Author(s):  
Michelle L. Aries ◽  
Mary J. Cloninger
Keyword(s):  
Metabolic Pathways ◽  
Qualitative Method ◽  
Bacterial Resistance ◽  
Proton Nuclear Magnetic Resonance ◽  
Gram Negative Bacteria ◽  
Wild Type ◽  
Gram Positive ◽  
Resistance Development ◽  
Gram Positive Bacteria ◽  
Positively Charged

Multivalent membrane disruptors are a relatively new antimicrobial scaffold that are difficult for bacteria to develop resistance to and can act on both Gram-positive and Gram-negative bacteria. Proton Nuclear Magnetic Resonance (1H NMR) metabolomics is an important method for studying resistance development in bacteria, since this is both a quantitative and qualitative method to study and identify phenotypes by changes in metabolic pathways. In this project, the metabolic differences between wild type Bacillus cereus (B. cereus) samples and B. cereus that was mutated through 33 growth cycles in a nonlethal dose of a multivalent antimicrobial agent were identified. For additional comparison, samples for analysis of the wild type and mutated strains of B. cereus were prepared in both challenged and unchallenged conditions. A C16-DABCO (1,4‑diazabicyclo-2,2,2-octane) and mannose functionalized poly(amidoamine) dendrimer (DABCOMD) were used as the multivalent quaternary ammonium antimicrobial for this hydrophilic metabolic analysis. Overall, the study reported here indicates that B. cereus likely change their peptidoglycan layer to protect themselves from the highly positively charged DABCOMD. This membrane fortification most likely leads to the slow growth curve of the mutated, and especially the challenged mutant samples. The association of these sample types with metabolites associated with energy expenditure is attributed to the increased energy required for the membrane fortifications to occur as well as to the decreased diffusion of nutrients across the mutated membrane.

Selective toxicity of ZnO nanoparticles toward Gram-positive bacteria and cancer cells by apoptosis through lipid peroxidation

2011 ◽  
Vol 7 (2) ◽  
pp. 184-192 ◽  
Author(s):  
Mariappan Premanathan ◽  
Krishnamoorthy Karthikeyan ◽  
Kadarkaraithangam Jeyasubramanian ◽  
Govindasamy Manivannan
Keyword(s):  
Lipid Peroxidation ◽  
Cancer Cells ◽  
Zno Nanoparticles ◽  
Selective Toxicity ◽  
Gram Positive ◽  
Gram Positive Bacteria

AIE based GSH activatable photosensitizer for imaging-guided photodynamic therapy

2020 ◽  
Vol 56 (71) ◽  
pp. 10317-10320 ◽  
Author(s):  
You-Hui Zhang ◽  
Xue Li ◽  
Li Huang ◽  
Hyeong Seok Kim ◽  
Jusung An ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Emission Characteristics ◽  
Aggregation Induced Emission ◽  
Photodynamic Therapy Of Cancer

A GSH activatable photosensitizer with aggregation-induced emission characteristics for imaging-guided photodynamic therapy of cancer cells.

scholarly journals Light-up bioprobe with aggregation-induced emission characteristics for real-time apoptosis imaging in target cancer cells

2014 ◽  
Vol 2 (2) ◽  
pp. 231-238 ◽  
Author(s):  
Dan Ding ◽  
Jing Liang ◽  
Haibin Shi ◽  
Ryan T. K. Kwok ◽  
Meng Gao ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Real Time ◽  
Emission Characteristics ◽  
Aggregation Induced Emission ◽  
Apoptosis Imaging ◽  
Target Cancer
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