Evaluation of Structure–Function Relationships of Aggregation-Induced Emission Luminogens for Simultaneous Dual Applications of Specific Discrimination and Efficient Photodynamic Killing of Gram-Positive Bacteria

2019 ◽  
Vol 141 (42) ◽  
pp. 16781-16789 ◽  
Author(s):  
Miaomiao Kang ◽  
Chengcheng Zhou ◽  
Shuangmei Wu ◽  
Bingran Yu ◽  
Zhijun Zhang ◽  
...  
Keyword(s):  
Structure Function ◽  
Gram Positive ◽  
Aggregation Induced Emission ◽  
Gram Positive Bacteria

A multifunctional luminogen with aggregation-induced emission characteristics for selective imaging and photodynamic killing of both cancer cells and Gram-positive bacteria

2018 ◽  
Vol 6 (23) ◽  
pp. 3894-3903 ◽  
Author(s):  
Miaomiao Kang ◽  
Ryan T. K. Kwok ◽  
Jianguo Wang ◽  
Han Zhang ◽  
Jacky W. Y. Lam ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Emission Characteristics ◽  
Gram Positive ◽  
Aggregation Induced Emission ◽  
Gram Positive Bacteria ◽  
Positively Charged

A positively charged multifunctional AIEgen was developed for selective imaging and photodynamic killing of cancer cells as well as Gram-positive bacteria.

scholarly journals Clostridial Neurotoxins: Structure, Function, and Implications to Other Bacterial Toxins

2021 ◽  
Vol 9 (11) ◽  
pp. 2206
Author(s):  
Shuowei Cai ◽  
Raj Kumar ◽  
Bal Ram Singh
Keyword(s):  
Structure Function ◽  
Molten Globule ◽  
Flexible Structures ◽  
Bacterial Toxins ◽  
Gram Positive ◽  
Gram Positive Bacteria ◽  
Clostridial Neurotoxins ◽  
Structure Function Relationship ◽  
Function Relationship ◽  
Relationship Of

Gram-positive bacteria are ancient organisms. Many bacteria, including Gram-positive bacteria, produce toxins to manipulate the host, leading to various diseases. While the targets of Gram-positive bacterial toxins are diverse, many of those toxins use a similar mechanism to invade host cells and exert their functions. Clostridial neurotoxins produced by Clostridial tetani and Clostridial botulinum provide a classical example to illustrate the structure–function relationship of bacterial toxins. Here, we critically review the recent progress of the structure–function relationship of clostridial neurotoxins, including the diversity of the clostridial neurotoxins, the mode of actions, and the flexible structures required for the activation of toxins. The mechanism clostridial neurotoxins use for triggering their activity is shared with many other Gram-positive bacterial toxins, especially molten globule-type structures. This review also summarizes the implications of the molten globule-type flexible structures to other Gram-positive bacterial toxins. Understanding these highly dynamic flexible structures in solution and their role in the function of bacterial toxins not only fills in the missing link of the high-resolution structures from X-ray crystallography but also provides vital information for better designing antidotes against those toxins.

Efficient photosensitizers with aggregation-induced emission characteristics for lysosome- and Gram-positive bacteria-targeted photodynamic therapy

2020 ◽  
Vol 56 (17) ◽  
pp. 2630-2633 ◽  
Author(s):  
Jiabao Zhuang ◽  
Hanxiao Yang ◽  
Yue Li ◽  
Bing Wang ◽  
Nan Li ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Cells ◽  
White Light ◽  
Light Irradiation ◽  
Emission Characteristics ◽  
Gram Positive ◽  
Aggregation Induced Emission ◽  
Gram Positive Bacteria ◽  
Targeted Photodynamic Therapy

Efficient photosensitizers with aggregation-induced emission effects were reported to selectively stain lysosome and Gram-positive bacteria, which further triggered the ablation of cancer cells and bacteria under white light irradiation.

A light-up probe with aggregation-induced emission characteristics (AIE) for selective imaging, naked-eye detection and photodynamic killing of Gram-positive bacteria

2015 ◽  
Vol 51 (62) ◽  
pp. 12490-12493 ◽  
Author(s):  
Guangxue Feng ◽  
Youyong Yuan ◽  
Hu Fang ◽  
Ruoyu Zhang ◽  
Bengang Xing ◽  
...  
Keyword(s):  
Selective Recognition ◽  
Emission Characteristics ◽  
Eye Detection ◽  
Gram Positive ◽  
Aggregation Induced Emission ◽  
Gram Positive Bacteria ◽  
Naked Eye ◽  
Resistant Strains ◽  
Vancomycin Resistant ◽  
Naked Eye Detection

We report a multifunctional light-up probe based on AIEgens for selective recognition, naked-eye identification, and photodynamic killing of Gram-positive bacteria including vancomycin-resistant strains.

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