Microenvironment construction of strontium–calcium-based biomaterials for bone tissue regeneration: the equilibrium effect of calcium to strontium

2018 ◽  
Vol 6 (15) ◽  
pp. 2332-2339 ◽  
Author(s):  
Huixu Xie ◽  
Zhipeng Gu ◽  
Yan He ◽  
Jia Xu ◽  
Chun Xu ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Formation ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Bone Tissue Regeneration ◽  
Beneficial Effects ◽  
Equilibrium Effect

Strontium-doped calcium phosphate-based biomaterials have gained increased recognition due to their beneficial effects on bone formation.

scholarly journals Icaritin Enhancing Bone Formation Initiated by Sub-Microstructured Calcium Phosphate Ceramic for Critical Size Defect Repair

2020 ◽  
Vol 7 ◽  
Author(s):  
Haitao Peng ◽  
Jianxiao Li ◽  
Yanan Xu ◽  
Guoyu Lv
Keyword(s):  
Calcium Phosphate ◽  
Bone Formation ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Bone Defects ◽  
Bone Tissue Regeneration ◽  
Calcium Phosphate Ceramic ◽  
Dose Dependent

Adequate bone tissue regeneration has been challenging to achieve at critical-sized bone defects caused by disease. Bone tissue engineering using a combination of scaffolds and bioactive factors provides new hope for the treatment of this extreme condition. Icaritin, a herb-derived chemical, has shown its ability to enhance bone formation both in vitro and in vivo, and it has been found that sub-micron surface structure instructs bone formation in calcium phosphate ceramics (CaPs). Here, we evaluated the possibility of using a submicron surface structured CaP ceramic as the carrier of icaritin for bone tissue regeneration in critical-sized bone defects. Icaritin, an herb-derived chemical, was loaded into a submicron surface structured porous calcium phosphate ceramic (Ø12.8 × 3 mm) to get samples with 0, 10, 50, 250, and 1,250 µg icaritin per CaP disc (M0, M10, M50, M250, M1250 groups, respectively). In vitro evaluation with the certain dosages correlated to those released from the samples showed a dose-dependent enhancement of osteogenic differentiation and mineralization of human bone marrow stromal cells with the presence of osteogenic factors in the culture medium, indicating icaritin is an osteopromotive factor. After intramuscular implantation of the samples in dogs for 8 weeks, a dose-dependent of bone formation was seen with enhanced bone formation at the dosage of 50 and 250 µg. To evaluate the in vivo osteogenic potentials of icaritin-containing CaP ceramic scaffolds in the orthopedic site, a 12.8 mm calvarial defect model in rabbits was established. Micro-computed tomography (micro-CT) and histology results at weeks 4, 8 and 12 post-surgery showed more newly formed bone in M250 group, with correspondingly more new vessel ingrowth. The results presented herein suggested that being osteopromotive, icaritin could enhance bone formation initiated by sub-microstructured CaP ceramics and the CaP ceramics scaffold incorporating icaritin is a promising biomaterial for the treatment of critical-sized defect.

Hierarchically microporous/macroporous scaffold of magnesium–calcium phosphate for bone tissue regeneration

Biomaterials ◽  
2010 ◽  
Vol 31 (6) ◽  
pp. 1260-1269 ◽  
Author(s):  
Jie Wei ◽  
Junfeng Jia ◽  
Fan Wu ◽  
Shicheng Wei ◽  
Huanjun Zhou ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Bone Tissue Regeneration

Preparation of an rhBMP-2 loaded mesoporous bioactive glass/calcium phosphate cement porous composite scaffold for rapid bone tissue regeneration

2015 ◽  
Vol 3 (43) ◽  
pp. 8558-8566 ◽  
Author(s):  
Nan Li ◽  
Chuan Jiang ◽  
Xingdi Zhang ◽  
Xinfeng Gu ◽  
Jingwei Zhang ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bioactive Glass ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Calcium Phosphate Cement ◽  
Composite Scaffold ◽  
Early Stage ◽  
Bone Tissue Regeneration ◽  
Porous Composite ◽  
Mesoporous Bioactive Glass

An rhBMP-2/MBG/CPC scaffold is beneficial for rapid bone tissue regeneration in the early stage.

Calcium phosphate coated Keratin–PCL scaffolds for potential bone tissue regeneration

2015 ◽  
Vol 49 ◽  
pp. 746-753 ◽  
Author(s):  
Xinxin Zhao ◽  
Yuan Siang Lui ◽  
Caleb Kai Chuen Choo ◽  
Wan Ting Sow ◽  
Charlotte Liwen Huang ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Bone Tissue Regeneration

scholarly journals Antibacterial Copper-Doped Calcium Phosphate Glasses for Bone Tissue Regeneration

2019 ◽  
Vol 5 (11) ◽  
pp. 6054-6062 ◽  
Author(s):  
Farzad Foroutan ◽  
Jamie McGuire ◽  
Priyanka Gupta ◽  
Athanasios Nikolaou ◽  
Benjamin A. Kyffin ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Phosphate Glasses ◽  
Bone Tissue Regeneration

Osteopontin sequence modified mesoporous calcium silicate scaffolds to promote angiogenesis in bone tissue regeneration

2020 ◽  
Vol 8 (27) ◽  
pp. 5849-5861
Author(s):  
Min Zhu ◽  
He He ◽  
Qingxi Meng ◽  
Yufang Zhu ◽  
Xiaojian Ye ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Calcium Silicate ◽  
Bone Tissue Regeneration ◽  
Surface Grafting

Surface grafting and encapsulation of SVVYGLR peptides in MCS promote vessel/bone formation all over the scaffold.

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