Microfluidic fabrication of vesicles with hybrid lipid/nanoparticle bilayer membranes

Soft Matter ◽  
2019 ◽  
Vol 15 (6) ◽  
pp. 1388-1395 ◽  
Author(s):  
Julie Perrotton ◽  
Rubén Ahijado-Guzmán ◽  
Lara H. Moleiro ◽  
Berta Tinao ◽  
Andrés Guerrero-Martinez ◽  
...  
Keyword(s):  
Double Emulsion ◽  
Bilayer Membranes ◽  
Lipid Nanoparticle ◽  
Oil In Water ◽  
Emulsion Drops

Water-in-oil-in-water double emulsion drops, fabricated using capillary microfluidics, enable the formation of vesicles with hybrid lipid/nanoparticle membranes.

A simple microfluidic method for one-step encapsulation of reagents with varying concentrations in double emulsion drops for nanoliter-scale reactions and analyses

2017 ◽  
Vol 9 (17) ◽  
pp. 2511-2516 ◽  
Author(s):  
Likai Hou ◽  
Yukun Ren ◽  
Yankai Jia ◽  
Xiaokang Deng ◽  
Zheng Tang ◽  
...  
Keyword(s):  
Double Emulsion ◽  
Oil In Water ◽  
Emulsion Drops ◽  
One Step

This work reports a simple microfluidic method for one-step encapsulation of two reagents with varying concentrations in water-in-oil-in-water (W/O/W) double-emulsion drops.

Electrocoalescence of paired droplets encapsulated in double-emulsion drops

Lab on a Chip ◽  
2016 ◽  
Vol 16 (22) ◽  
pp. 4313-4318 ◽  
Author(s):  
Yankan Jia ◽  
Yukun Ren ◽  
Weiyu Liu ◽  
Likai Hou ◽  
Ye Tao ◽  
...  
Keyword(s):  
Electric Field ◽  
Double Emulsion ◽  
On Demand ◽  
Ac Electric Field ◽  
Oil In Water ◽  
Emulsion Drops

We utilize an ac electric field to trigger the on-demand fusion of two aqueous cores inside water-in-oil-in-water (W/O/W) double-emulsion drops.

scholarly journals Generation of Ultra-Thin-Shell Microcapsules Using Osmolarity-Controlled Swelling Method

Micromachines ◽  
2020 ◽  
Vol 11 (4) ◽  
pp. 444 ◽  
Author(s):  
Jianhua Guo ◽  
Lihua Hou ◽  
Junpeng Hou ◽  
Jiali Yu ◽  
Qingming Hu
Keyword(s):  
Thin Shell ◽  
Shell Thickness ◽  
Double Emulsion ◽  
Spherical Shape ◽  
Thin Shells ◽  
Biomolecular Sensing ◽  
Oil In Water ◽  
Emulsion Drops ◽  
Long Term Observation

Microcapsules are attractive core-shell configurations for studies of controlled release, biomolecular sensing, artificial microbial environments, and spherical film buckling. However, the production of microcapsules with ultra-thin shells remains a challenge. Here we develop a simple and practical osmolarity-controlled swelling method for the mass production of monodisperse microcapsules with ultra-thin shells via water-in-oil-in-water (W/O/W) double-emulsion drops templating. The size and shell thickness of the double-emulsion drops are precisely tuned by changing the osmotic pressure between the inner cores and the suspending medium, indicating the practicability and effectiveness of this swelling method in tuning the shell thickness of double-emulsion drops and the resultant microcapsules. This method enables the production of microcapsules even with an ultra-thin shell less than hundreds of nanometers, which overcomes the difficulty in producing ultra-thin-shell microcapsules using the classic microfluidic emulsion technologies. In addition, the ultra-thin-shell microcapsules can maintain their intact spherical shape for up to 1 year without rupturing in our long-term observation. We believe that the osmolarity-controlled swelling method will be useful in generating ultra-thin-shell polydimethylsiloxane (PDMS) microcapsules for long-term encapsulation, and for thin film folding, buckling and rupturing investigation.

scholarly journals Microencapsulation of Purple Cactus Pear Fruit (Opuntia ficus indica) Extract by the Combined Method W/O/W Double Emulsion-Spray Drying and Conventional Spray Drying: A Comparative Study

Processes ◽  
2018 ◽  
Vol 6 (10) ◽  
pp. 189 ◽  
Author(s):  
Keren Toledo-Madrid ◽  
Tzayhrí Gallardo-Velázquez ◽  
Guillermo Osorio-Revilla
Keyword(s):  
Spray Drying ◽  
Desirability Function ◽  
Double Emulsion ◽  
Dry Weight ◽  
Antioxidant Compounds ◽  
Pear Fruit ◽  
Cactus Pear ◽  
Opuntia Ficus Indica ◽  
Globule Size ◽  
Oil In Water

The aim of this study was to microencapsulate an optimized extract of purple cactus pear fruit (Opuntia ficus indica), rich in phenolic compounds (PC), betacyanins (BC), and betaxanthins (BX), with antioxidant capacity (AC), by two methodologies: combined water-in-oil-in water double emulsions-spray drying (W/O/W-SP) and conventional spray drying, studying the effect of spray drying (SP) on PC and AC. Optimal extraction conditions for bioactive compounds were: 52 °C, for 30 min, using aqueous ethanol (40%) as the solvent, with a 0.85 desirability function, obtaining 17.39 ± 0.11 mg GAE/gdw (gallic acid equivalents per gram of dry weight) for PC, 0.35 mg BE/gdw (betanin equivalents per gram of dry weight) for BC, and 0.26 mg IE/gdw (indicaxanthin equivalents per gram of dry weight) for BX. The best combination of temperatures for conventional SP and W/O/W-SP was 160–80 °C obtaining the highest retention and encapsulation efficiencies for PC. For conventional SP, results were: 107% and 100% PC and AC retention efficiencies (RE-PC and RE-AC), respectively, with 97% of PC encapsulation efficiency (EE-PC), meanwhile for the W/O/W-SP results were: 78% and 103% RE-PC and RE-AC, respectively, with 70% of EE-PC. Microcapsules obtained with W/O/W-SP maintained their structure and integrity and showed a considerable reduction in globule size in the reconstituted W/O/W emulsions due to the spray drying stress. Despite having lower EE-PC than conventional SP, spray dried W/O/W emulsions seems to be a promising controlled-delivery vehicle for antioxidant compounds.

Composite Microgels Created by Complexation between Polyvinyl Alcohol and Graphene Oxide in Compressed Double‐Emulsion Drops

Small ◽  
2019 ◽  
Vol 16 (9) ◽  
pp. 1903812 ◽  
Author(s):  
Ye Hun Choi ◽  
Sang Seok Lee ◽  
Dong‐Myeong Lee ◽  
Hyeon Su Jeong ◽  
Shin‐Hyun Kim
Keyword(s):  
Graphene Oxide ◽  
Polyvinyl Alcohol ◽  
Double Emulsion ◽  
Emulsion Drops

Double-emulsion drops with ultra-thin shells for capsule templates

Lab on a Chip ◽  
2011 ◽  
Vol 11 (18) ◽  
pp. 3162-3166 ◽  
Author(s):  
Shin-Hyun Kim ◽  
Jin Woong Kim ◽  
Jun-Cheol Cho ◽  
David A. Weitz
Keyword(s):  
Double Emulsion ◽  
Thin Shells ◽  
Emulsion Drops

Fabrication of Ofloxacin/PLGA Microsphere for Bone Tuberculosis Therapy

2013 ◽  
Vol 647 ◽  
pp. 176-180 ◽  
Author(s):  
Gang Wu ◽  
Long Chen ◽  
Chun Ling Deng ◽  
Kun Wei
Keyword(s):  
Double Emulsion ◽  
Distribution Analysis ◽  
Mesoporous Silicon ◽  
Water Solvent ◽  
Loading Efficiency ◽  
Internal Phase ◽  
Oil In Water ◽  
Phase Group ◽  
Bone Tuberculosis ◽  
Tuberculosis Therapy

The purpose of this research was to use mesoporous silicon (mpSi) as internal phase additive to improve the hydrophilic ofloxacin loaded by the hydrophobic PLGA materials through a double emulsion (water-in-oil-in-water) solvent extraction/evaporation method. Laser distribution analysis displayed low impact of MS additive on the final particles size. When compared to particle loading efficiency of none internal phase additives, MS internal phase group showed higher loading efficiency, and it increased with MS amounts inside the microparticles. All the burst releases of MS internal phase groups were severe than none MS group and was directly related the MS amount inside the microsphere. The release rate was increasing with the MS amounts added into the internal phase.

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