scholarly journals Rapid chemiexcitation of phenoxy-dioxetane luminophores yields ultrasensitive chemiluminescence assays

2019 ◽  
Vol 10 (5) ◽  
pp. 1380-1385 ◽  
Author(s):  
Nir Hananya ◽  
Jolene P. Reid ◽  
Ori Green ◽  
Matthew S. Sigman ◽  
Doron Shabat
Keyword(s):  
Rational Design ◽  
Next Generation ◽  
Increased Sensitivity

Rational design of phenoxy-dioxetane luminophores with rapid chemiexcitation is described; these next generation luminophores yielded chemiluminescent probes with considerably increased sensitivity.

Rational design on materials for developing next generation lithium-ion secondary battery

2020 ◽  
pp. 100298
Author(s):  
Arun Mambazhasseri Divakaran ◽  
Manickam Minakshi ◽  
Parisa Arabzadeh Bahri ◽  
Shashi Paul ◽  
Pooja Kumari ◽  
...  
Keyword(s):  
Rational Design ◽  
Lithium Ion ◽  
Next Generation ◽  
Secondary Battery

scholarly journals Rational Design of MOF-Based Materials for Next-Generation Rechargeable Batteries

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Zhengqing Ye ◽  
Ying Jiang ◽  
Li Li ◽  
Feng Wu ◽  
Renjie Chen
Keyword(s):  
High Performance ◽  
Rational Design ◽  
Metal Organic Framework ◽  
Rechargeable Batteries ◽  
High Porosity ◽  
Next Generation ◽  
Battery System ◽  
Lithium Sulfur Batteries ◽  
Metal Organic ◽  
Lithium Oxygen Batteries

AbstractMetal–organic framework (MOF)-based materials with high porosity, tunable compositions, diverse structures, and versatile functionalities provide great scope for next-generation rechargeable battery applications. Herein, this review summarizes recent advances in pristine MOFs, MOF composites, MOF derivatives, and MOF composite derivatives for high-performance sodium-ion batteries, potassium-ion batteries, Zn-ion batteries, lithium–sulfur batteries, lithium–oxygen batteries, and Zn–air batteries in which the unique roles of MOFs as electrodes, separators, and even electrolyte are highlighted. Furthermore, through the discussion of MOF-based materials in each battery system, the key principles for controllable synthesis of diverse MOF-based materials and electrochemical performance improvement mechanisms are discussed in detail. Finally, the major challenges and perspectives of MOFs are also proposed for next-generation battery applications.

scholarly journals Orthosteric-allosteric dual inhibitors of PfHT1 as selective anti-malarial agents

2020 ◽  
Author(s):  
Jian Huang ◽  
Yafei Yuan ◽  
Na Zhao ◽  
Debing Pu ◽  
Qingxuan Tang ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Rational Design ◽  
Glucose Transporter ◽  
Blood Stage ◽  
Host Cells ◽  
Sugar Uptake ◽  
Hexose Transporter ◽  
Next Generation ◽  
Malaria Parasites ◽  
Glucose Transporter 1

AbstractArtemisinin-resistant malaria parasites have emerged and been spreading, posing a significant public health challenge. Anti-malarial drugs with novel mechanisms of action are therefore urgently needed. In this report, we exploit a “selective starvation” strategy by selectively inhibiting Plasmodium falciparum hexose transporter 1 (PfHT1), the sole hexose transporter in Plasmodium falciparum, over human glucose transporter 1 (hGLUT1), providing an alternative approach to fight against multidrug-resistant malaria parasites. Comparison of the crystal structures of human GLUT3 and PfHT1 bound to C3361, a PfHT1-specific moderate inhibitor, revealed an inhibitor binding-induced pocket that presented a promising druggable site. We thereby designed small-molecules to simultaneously block the orthosteric and allosteric pockets of PfHT1. Through extensive structure-activity relationship (SAR) studies, the TH-PF series was identified to selectively inhibit PfHT1 over GLUT1 and potent against multiple strains of the blood-stage P. falciparum. Our findings shed light on the next-generation chemotherapeutics with a paradigm-shifting structure-based design strategy to simultaneously targeting the orthosteric and allosteric sites of a transporter.Significance statementBlocking sugar uptake in P. falciparum by selectively inhibiting the hexose transporter PfHT1 kills the blood-stage parasites without affecting the host cells, indicating PfHT1 as a promising therapeutic target. Here, we report the development of novel small-molecule inhibitors that are selectively potent to the malaria parasites over human cell lines by simultaneously targeting the orthosteric and the allosteric binding sites of PfHT1. Our findings established the basis for the rational design of next-generation anti-malarial drugs.

scholarly journals Increased sensitivity of next generation sequencing-based expression profiling after globin reduction in human blood RNA

BMC Genomics ◽  
2012 ◽  
Vol 13 (1) ◽  
pp. 28 ◽  
Author(s):  
Anastasios Mastrokolias ◽  
Johan T den Dunnen ◽  
GertJan B van Ommen ◽  
Peter AC 't Hoen ◽  
Willeke MC van Roon-Mom
Keyword(s):  
Next Generation Sequencing ◽  
Human Blood ◽  
Expression Profiling ◽  
Next Generation ◽  
Globin Reduction ◽  
Increased Sensitivity ◽  
Generation Sequencing

scholarly journals Signal Coding and CMOS Gates for Combinational Functional Blocks of Very Deep Submicron Self-checking Circuits

VLSI Design ◽  
2000 ◽  
Vol 11 (1) ◽  
pp. 23-34 ◽  
Author(s):  
Cecilia Metra ◽  
Michele Favalli ◽  
Bruno Riccò
Keyword(s):  
Deep Submicron ◽  
Transient Faults ◽  
Next Generation ◽  
Electrical Parameters ◽  
Parameter Variations ◽  
Increased Sensitivity ◽  
Functional Blocks ◽  
Internal Faults ◽  
Signal Coding

In this paper we propose signal coding and CMOS gates that are suitable to self-checking circuits with combinational functional blocks implemented also by next generation, very deep submicron technology. In particular, our functional blocks satisfy the Strongly Fault-Secure property with respect to a wide set of possible, internal faults including not only conventional stuck-ats, but also transistor stuck-ons, transistor stuck-opens, resistive bridgings, delays, crosstalks and transient faults, that are very likely to affect next generation ICs. Compared to alternative, existing solutions, that proposed here does not imply any critical constraint on the circuit electrical parameters. Therefore, it is suitable to be adopted to design very deep submicron self-checking circuits which, compared to todays' circuits, will present significantly increased sensitivity to parameter variations occurring during fabrication.

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