scholarly journals Enantioselective radical process for synthesis of chiral indolines by metalloradical alkylation of diverse C(sp3)–H bonds

2018 ◽  
Vol 9 (22) ◽  
pp. 5082-5086 ◽  
Author(s):  
Xin Wen ◽  
Yong Wang ◽  
X. Peter Zhang
Keyword(s):  
Stereoselective Synthesis ◽  
Bond Formation ◽  
Radical Process

A new C–C bond formation strategy based on enantioselective radical alkylation of C(sp3)–H bonds via Co(ii)-based metalloradical catalysis has been demonstrated for stereoselective synthesis of chiral indolines.

Allylstannylation of alkynes via a radical process: stereoselective synthesis of di- and tri-substituted vinylstannanes

1996 ◽  
Vol 37 (47) ◽  
pp. 8539-8542 ◽  
Author(s):  
Katsukiyo Miura ◽  
Daisuke Itoh ◽  
Takeshi Hondo ◽  
Hiroshi Saito ◽  
Hajime Ito ◽  
...  
Keyword(s):  
Stereoselective Synthesis ◽  
Radical Process

Metal-free enaminone C-N bond cyanation for stereoselective synthesis of (E)- and (Z)-β-cyano enones

2021 ◽  
Author(s):  
Ting Liu ◽  
Jie-Ping Wan ◽  
Yunyun Liu
Keyword(s):  
Stereoselective Synthesis ◽  
Bond Cleavage ◽  
Bond Formation ◽  
Practical Method ◽  
Efficient Synthesis ◽  
Metal Free

A highly practical method for C-CN bond formation by C-N bond cleavage on enaminones leading to the efficient synthesis of β-cyano enones is developed. The reactions take place efficiently to...

Taming Silylium Ions for Synthesis: N-Heterocycle Synthesis via Stereoselective C–C Bond Formation

Synlett ◽  
2017 ◽  
Vol 28 (18) ◽  
pp. 2429-2434 ◽  
Author(s):  
Michel Gagné ◽  
Brandon Moyer
Keyword(s):  
Medicinal Chemistry ◽  
Stereoselective Synthesis ◽  
Bond Formation ◽  
Amino Alcohols ◽  
High Reactivity ◽  
Lewis Acidity ◽  
Enol Ethers ◽  
Heterocycle Synthesis ◽  
The Subject ◽  
Elusive Species

Silylium ions (formally [R3Si]+) have long been the subject of investigations and significant debate in both theoretical and experimental chemistry, but few catalytic, synthetic applications have been reported due to the exceptionally high reactivity and Lewis acidity of these elusive species. Results to be discussed include the application of easily accessible silylium ion catalysts to the stereoselective synthesis of various N-heterocyclic pyrrolidine and piperidine scaffolds. The tested substrates are derived from the chiral pool and can be obtained in three high-yielding steps from amino alcohols; subsequent stereoselective silylium ion catalyzed Prins cyclization and trapping with R3Si–Nu nucleophiles (e.g., Nu = H, allyl, azide, and enol ethers) results in novel nitrogen-containing polycyclic scaffolds with potential medicinal chemistry applications.

Nickel-catalyzed regioselective C–H acylation of chelating arenes: a new catalytic system for C–C bond formation via a radical process and its mechanistic explorations

2019 ◽  
Vol 43 (30) ◽  
pp. 12152-12158 ◽  
Author(s):  
Ze-lin Li ◽  
Peng-yu Wu ◽  
Kang-kang Sun ◽  
Chun Cai
Keyword(s):  
Catalytic System ◽  
Bond Formation ◽  
Radical Process ◽  
Dehydrogenative Coupling ◽  
Coupling Strategy

An unprecedented acylation at the ortho C–H bond of chelating arenes via the Ni(ii)-catalyzed cross dehydrogenative coupling strategy has been developed here.

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