scholarly journals Chemoenzymatic Carbon-Carbon Bond Formation Leading to Non-carbohydrate Derivative. Stereoselective Synthesis of Pentamycin C-11-C-16 Fragment.

1993 ◽  
Vol 41 (2) ◽  
pp. 282-286 ◽  
Author(s):  
Masayuki SHIMAGAKI ◽  
Hiroaki MUNESHIMA ◽  
Masahide KUBOTA ◽  
Takeshi OISHI
Keyword(s):  
Stereoselective Synthesis ◽  
Bond Formation ◽  
Carbon Bond ◽  
Carbon Carbon Bond ◽  
Carbohydrate Derivative

Highly Stereoselective Synthesis of Fluoroalkene Dipeptides via the Novel Chromium(II)-Mediated Carbon–Fluorine Bond Cleavage/New Carbon–Carbon Bond Formation

Synthesis ◽  
2015 ◽  
Vol 48 (06) ◽  
pp. 865-881 ◽  
Author(s):  
Tsutomu Konno ◽  
Takashi Nihei ◽  
Yuji Nishi ◽  
Natsumi Ikeda ◽  
Saya Yokotani ◽  
...  
Keyword(s):  
Stereoselective Synthesis ◽  
Bond Cleavage ◽  
Bond Formation ◽  
The Novel ◽  
Carbon Bond ◽  
Carbon Carbon Bond

Carbon Dioxide-Mediated C(sp2)–H Arylation of Primary and Secondary Benzylamines

2018 ◽  
Author(s):  
Mohit Kapoor ◽  
Pratibha Chand-Thakuri ◽  
Michael Young
Keyword(s):  
Carbon Dioxide ◽  
Transition Metal ◽  
Bond Activation ◽  
Bond Formation ◽  
Carbon Bond ◽  
Chelate Effect ◽  
Free Amine ◽  
Carbon Carbon Bond ◽  
New Strategy ◽  
Metal Catalyzed

Carbon-carbon bond formation by transition metal-catalyzed C–H activation has become an important strategy to fabricate new bonds in a rapid fashion. Despite the pharmacological importance of <i>ortho</i>-arylbenzylamines, however, effective <i>ortho</i>-C–C bond formation from C–H bond activation of free primary and secondary benzylamines using Pd<sup>II</sup> remains an outstanding challenge. Presented herein is a new strategy for constructing <i>ortho</i>-arylated primary and secondary benzylamines mediated by carbon dioxide (CO<sub>2</sub>). The use of CO<sub>2</sub> is critical to allowing this transformation to proceed under milder conditions than previously reported, and that are necessary to furnish free amine products that can be directly used or elaborated without the need for deprotection. In cases where diarylation is possible, a chelate effect is demonstrated to facilitate selective monoarylation.

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